Comparative GO Graph (mouse, human)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SORBS1
  • Mouse genes Sorbs1
  • Rat genes
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sorbs1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005158	insulin receptor binding	SORBS1	IDA		Human	PMID:11374898
Molecular Function	GO:0005158	insulin receptor binding	Sorbs1	IPI	UniProtKB:P15208	Mouse	MGI:MGI:1201213|PMID:9447983
Molecular Function	GO:0005158	insulin receptor binding	Sorbs1	IDA		Mouse	MGI:MGI:1201213|PMID:9447983
Molecular Function	GO:0005515	protein binding	SORBS1	IPI	UniProtKB:O15265	Human	PMID:11371513
Molecular Function	GO:0005515	protein binding	SORBS1	IPI	UniProtKB:P00519	Human	PMID:11374898
Molecular Function	GO:0005515	protein binding	SORBS1	IPI	UniProtKB:P06213	Human	PMID:11374898
Molecular Function	GO:0005515	protein binding	SORBS1	IPI	UniProtKB:Q9PVZ4	Human	PMID:11374898
Molecular Function	GO:0005515	protein binding	SORBS1	IPI	UniProtKB:A0A061I5T4	Human	PMID:12504111
Molecular Function	GO:0005515	protein binding	SORBS1	IPI	UniProtKB:O15357	Human	PMID:12504111
Molecular Function	GO:0005515	protein binding	SORBS1	IPI	UniProtKB:Q13177	Human	PMID:16374509
Molecular Function	GO:0005515	protein binding	SORBS1	IPI	UniProtKB:P42858	Human	PMID:17500595
Molecular Function	GO:0005515	protein binding	SORBS1	IPI	UniProtKB:P39052	Human	PMID:19116150
Molecular Function	GO:0005515	protein binding	SORBS1	IPI	UniProtKB:O15265	Human	PMID:23892081
Molecular Function	GO:0005515	protein binding	SORBS1	IPI	UniProtKB:Q6NSK7	Human	PMID:31413325
Molecular Function	GO:0005515	protein binding	Sorbs1	IPI	UniProtKB:O08917	Mouse	MGI:MGI:3690172|PMID:11001060
Molecular Function	GO:0005515	protein binding	Sorbs1	IPI	UniProtKB:Q64727	Mouse	MGI:MGI:3694165|PMID:10085297
Molecular Function	GO:0005515	protein binding	Sorbs1	IPI	UniProtKB:Q63ZV0	Mouse	MGI:MGI:2182863|PMID:12079283
Molecular Function	GO:0005515	protein binding	Sorbs1	IPI	UniProtKB:P34152	Mouse	MGI:MGI:1196128|PMID:9461600
Molecular Function	GO:0005515	protein binding	Sorbs1	IPI	UniProtKB:P15208|UniProtKB:P22682	Mouse	MGI:MGI:1201213|PMID:9447983
Molecular Function	GO:0005515	protein binding	Sorbs1	IPI	UniProtKB:P18206|UniProtKB:P49023	Mouse	MGI:MGI:5508619|PMID:17082770
Molecular Function	GO:0005515	protein binding	Sorbs1	IPI	UniProtKB:Q9W6V6	Mouse	MGI:MGI:5447620|PMID:15777793
Molecular Function	GO:0005515	protein binding	Sorbs1	IPI	PR:P47941	Mouse	PMID:26527617
Molecular Function	GO:0019901	protein kinase binding	Sorbs1	IDA		Mouse	PMID:9461600
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	SORBS1	IDA		Human	PMID:11374898
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	Sorbs1	IPI	UniProtKB:P22681|UniProtKB:P22682	Mouse	MGI:MGI:1201213|PMID:9447983
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Sorbs1	IPI	UniProtKB:P22681	Mouse	MGI:MGI:1201213|PMID:9447983
Cellular Component	GO:0005912	adherens junction	Sorbs1	IDA		Mouse	MGI:MGI:3694165|PMID:10085297
Cellular Component	GO:0030055	cell-substrate junction	Sorbs1	IDA		Mouse	MGI:MGI:3694165|PMID:10085297
Cellular Component	GO:0005813	centrosome	SORBS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005856	cytoskeleton	Sorbs1	IDA		Mouse	MGI:MGI:5447620|PMID:15777793
Cellular Component	GO:0005829	cytosol	Sorbs1	IDA		Mouse	MGI:MGI:1201213|PMID:9447983
Cellular Component	GO:0016600	flotillin complex	Sorbs1	IDA		Mouse	MGI:MGI:3690172|PMID:11001060
Cellular Component	GO:0005925	focal adhesion	SORBS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	Sorbs1	IDA		Mouse	MGI:MGI:1201213|PMID:9447983
Cellular Component	GO:0045121	membrane raft	Sorbs1	IDA		Mouse	MGI:MGI:3690172|PMID:11001060
Cellular Component	GO:0016363	nuclear matrix	Sorbs1	IDA		Mouse	MGI:MGI:5447620|PMID:15777793
Cellular Component	GO:0005634	nucleus	SORBS1	IDA		Human	PMID:11371513
Cellular Component	GO:0005634	nucleus	Sorbs1	IDA		Mouse	MGI:MGI:5447620|PMID:15777793
Cellular Component	GO:0005886	plasma membrane	SORBS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0001725	stress fiber	Sorbs1	IDA		Mouse	PMID:9461600
Cellular Component	GO:0045202	synapse	Sorbs1	IDA		Mouse	PMID:26527617
Biological Process	GO:0095500	acetylcholine receptor signaling pathway	Sorbs1	IGI	MGI:MGI:1924574	Mouse	PMID:26527617
Biological Process	GO:0095500	acetylcholine receptor signaling pathway	Sorbs1	IGI	MGI:MGI:104686	Mouse	PMID:26527617
Biological Process	GO:0032869	cellular response to insulin stimulus	Sorbs1	IMP		Mouse	MGI:MGI:3690172|PMID:11001060
Biological Process	GO:0048041	focal adhesion assembly	Sorbs1	IDA		Mouse	MGI:MGI:1196128|PMID:9461600
Biological Process	GO:0008286	insulin receptor signaling pathway	Sorbs1	IDA		Mouse	MGI:MGI:1201213|PMID:9447983
Biological Process	GO:0046326	positive regulation of glucose import	Sorbs1	IMP		Mouse	MGI:MGI:3690172|PMID:11001060
Biological Process	GO:0046326	positive regulation of glucose import	Sorbs1	IDA		Mouse	MGI:MGI:3690172|PMID:11001060
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	Sorbs1	IMP		Mouse	MGI:MGI:3690172|PMID:11001060
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	Sorbs1	IDA		Mouse	MGI:MGI:3690172|PMID:11001060
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	Sorbs1	IMP		Mouse	MGI:MGI:3690172|PMID:11001060
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	Sorbs1	IMP		Mouse	MGI:MGI:3690172|PMID:11001060
Biological Process	GO:1904393	regulation of skeletal muscle acetylcholine-gated channel clustering	Sorbs1	IGI	MGI:MGI:1924574	Mouse	PMID:26527617
Biological Process	GO:1904393	regulation of skeletal muscle acetylcholine-gated channel clustering	Sorbs1	IGI	MGI:MGI:104686	Mouse	PMID:26527617
Biological Process	GO:0043149	stress fiber assembly	Sorbs1	IDA		Mouse	MGI:MGI:1196128|PMID:9461600

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern