Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SORT1
  • Mouse genes Sort1
  • Rat genes Sort1
  • Zfish genes sort1a,sort1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sort1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	SORT1	IPI	UniProtKB:P06858	Human	PMID:10085125
Molecular Function	GO:0048406	nerve growth factor binding	SORT1	IPI	UniProtKB:P01138	Human	PMID:14985763
Molecular Function	GO:0010465	nerve growth factor receptor activity	SORT1	IDA		Human	PMID:14985763
Molecular Function	GO:0030379	neurotensin receptor activity, non-G protein-coupled	SORT1	IDA		Human	PMID:9756851
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P11151	Human	PMID:10085125
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P30533	Human	PMID:10085125
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:Q9UJY5	Human	PMID:11390366
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P01138	Human	PMID:14985763
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P01138:PRO_0000019599	Human	PMID:14985763
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P17405	Human	PMID:16787399
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P01266	Human	PMID:18687776
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P06882	Human	PMID:18687776
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P30533	Human	PMID:18687776
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P01138	Human	PMID:19122660
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P30533	Human	PMID:19122660
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P26441	Human	PMID:20584990
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P30533	Human	PMID:20584990
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P42702	Human	PMID:20584990
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P83714	Human	PMID:20584990
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:Q9UJY5	Human	PMID:20676133
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P28799	Human	PMID:21092856
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P04629	Human	PMID:21102451
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:Q16288	Human	PMID:21102451
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P06280	Human	PMID:21949853
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:O75503	Human	PMID:22431521
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P07602	Human	PMID:22431521
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P28799	Human	PMID:23236149
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P28799	Human	PMID:24070898
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:Q8WY21	Human	PMID:24128306
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:Q99523:PRO_0000033162	Human	PMID:24128306
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:Q9JLC4	Human	PMID:24128306
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P05231	Human	PMID:25401472
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:Q99523:PRO_0000033162	Human	PMID:25401472
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P28799,UniProtKB:Q61207	Human	PMID:28541286
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:O95183	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P02787	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:P23560-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:Q6PL45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:Q8TBE1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:Q92520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:Q96K78	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SORT1	IPI	UniProtKB:Q9UBQ0-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Sort1	IPI	UniProtKB:Q9EQH3	Mouse	MGI:MGI:3795652|PMID:18480253
Molecular Function	GO:0005515	protein binding	Sort1	IPI	UniProtKB:P12023	Mouse	MGI:MGI:5468380|PMID:23283322
Molecular Function	GO:0005515	protein binding	Sort1	IPI	UniProtKB:P97438	Mouse	MGI:MGI:4452544|PMID:20405001
Molecular Function	GO:0005515	protein binding	Sort1	IPI	UniProtKB:Q9EQH3	Mouse	MGI:MGI:4867115|PMID:21040701
Molecular Function	GO:0005515	protein binding	Sort1	IPI	UniProtKB:P15209	Mouse	MGI:MGI:5560429|PMID:24355921
Molecular Function	GO:0005515	protein binding	Sort1	IPI	UniProtKB:P15209	Mouse	MGI:MGI:4946148|PMID:21102451
Molecular Function	GO:0005515	protein binding	Sort1	IPI	UniProtKB:Q8CJ26	Mouse	MGI:MGI:3849336|PMID:19407813
Molecular Function	GO:0005515	protein binding	Sort1	IPI	PR:Q09163	Mouse	PMID:24928897
Molecular Function	GO:0005515	protein binding	Sort1	IPI	PR:Q9DB50	Mouse	PMID:24928897
Molecular Function	GO:1905394	retromer complex binding	SORT1	IDA		Human	PMID:18817523
Cellular Component	GO:0009986	cell surface	SORT1	IDA		Human	PMID:10085125
Cellular Component	GO:0150053	cerebellar climbing fiber to Purkinje cell synapse	Sort1	IDA		Mouse	PMID:29398357
Cellular Component	GO:0150053	cerebellar climbing fiber to Purkinje cell synapse	Sort1	IMP		Mouse	PMID:29398357
Cellular Component	GO:0005905	clathrin-coated pit	SORT1	IDA		Human	PMID:11331584
Cellular Component	GO:0030136	clathrin-coated vesicle	SORT1	IDA		Human	PMID:11331584
Cellular Component	GO:0031410	cytoplasmic vesicle	SORT1	IDA		Human	PMID:9756851
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	Sort1	IDA		Mouse	PMID:12490950
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	Sort1	IDA		Mouse	PMID:26629404
Cellular Component	GO:0005829	cytosol	SORT1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030425	dendrite	Sort1	IDA		Rat	PMID:12746864|RGD:1299257
Cellular Component	GO:0005769	early endosome	SORT1	IDA		Human	PMID:11331584
Cellular Component	GO:0010008	endosome membrane	SORT1	IDA		Human	PMID:18817523
Cellular Component	GO:0005794	Golgi apparatus	SORT1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	SORT1	IDA		Human	PMID:11331584
Cellular Component	GO:0005794	Golgi apparatus	SORT1	IDA		Human	PMID:16787399
Cellular Component	GO:0005794	Golgi apparatus	SORT1	IDA		Human	PMID:18817523
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Sort1	IDA		Rat	PMID:12746864|RGD:1299257
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Sort1	IDA		Rat	PMID:9452485|RGD:730041
Cellular Component	GO:0005764	lysosome	SORT1	IDA		Human	PMID:28541286
Cellular Component	GO:0016020	membrane	SORT1	IDA		Human	PMID:15992544
Cellular Component	GO:0016020	membrane	Sort1	IDA		Rat	PMID:12746864|RGD:1299257
Cellular Component	GO:0043025	neuronal cell body	Sort1	IDA		Rat	PMID:12746864|RGD:1299257
Cellular Component	GO:0048471	perinuclear region of cytoplasm	SORT1	IDA		Human	PMID:11331584
Cellular Component	GO:0005886	plasma membrane	SORT1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	SORT1	IDA		Human	PMID:11331584
Cellular Component	GO:0005886	plasma membrane	Sort1	IDA		Mouse	MGI:MGI:3582104|PMID:15992544
Cellular Component	GO:0005886	plasma membrane	Sort1	IDA		Rat	PMID:9452485|RGD:730041
Cellular Component	GO:0030140	trans-Golgi network transport vesicle	Sort1	IDA		Mouse	PMID:15078902
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	sort1b	IDA		Zfish	PMID:18618001
Biological Process	GO:0006897	endocytosis	SORT1	IDA		Human	PMID:11331584
Biological Process	GO:0006897	endocytosis	SORT1	IDA		Human	PMID:21092856
Biological Process	GO:0006897	endocytosis	Sort1	IMP		Mouse	PMID:24163244
Biological Process	GO:0008333	endosome to lysosome transport	SORT1	IDA		Human	PMID:11331584
Biological Process	GO:0032509	endosome transport via multivesicular body sorting pathway	SORT1	IDA		Human	PMID:11331584
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	SORT1	IDA		Human	PMID:14985763
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	SORT1	IMP		Human	PMID:18258592
Biological Process	GO:0046323	glucose import	SORT1	IMP		Human	PMID:15992544
Biological Process	GO:0046323	glucose import	Sort1	IMP		Mouse	MGI:MGI:3582104|PMID:15992544
Biological Process	GO:0006895	Golgi to endosome transport	SORT1	IDA		Human	PMID:11331584
Biological Process	GO:0090160	Golgi to lysosome transport	SORT1	IDA		Human	PMID:16787399
Biological Process	GO:0099558	maintenance of synapse structure	Sort1	IMP		Mouse	PMID:29398357
Biological Process	GO:0099558	maintenance of synapse structure	Sort1	IDA		Mouse	PMID:29398357
Biological Process	GO:0014902	myotube differentiation	SORT1	IMP		Human	PMID:18258592
Biological Process	GO:0014902	myotube differentiation	Sort1	IMP		Mouse	MGI:MGI:3777515|PMID:18258592
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Sort1	IDA		Mouse	PMID:24928897
Biological Process	GO:0051005	negative regulation of lipoprotein lipase activity	SORT1	IDA		Human	PMID:10085125
Biological Process	GO:0007218	neuropeptide signaling pathway	SORT1	IDA		Human	PMID:9756851
Biological Process	GO:0048011	neurotrophin TRK receptor signaling pathway	SORT1	IMP		Human	PMID:14985763
Biological Process	GO:0048227	plasma membrane to endosome transport	SORT1	IDA		Human	PMID:11331584
Biological Process	GO:1904037	positive regulation of epithelial cell apoptotic process	Sort1	IMP		Rat	PMID:22555848|RGD:10059425
Biological Process	GO:0006622	protein targeting to lysosome	Sort1	IMP	MGI:MGI:4397584	Mouse	PMID:19732768
Biological Process	GO:0010468	regulation of gene expression	SORT1	IMP		Human	PMID:18258592
Biological Process	GO:0032868	response to insulin	SORT1	IMP		Human	PMID:15992544
Biological Process	GO:0032868	response to insulin	Sort1	IMP		Mouse	MGI:MGI:3582104|PMID:15992544
Biological Process	GO:0016050	vesicle organization	SORT1	IDA		Human	PMID:15992544
Biological Process	GO:0016050	vesicle organization	Sort1	IMP		Mouse	MGI:MGI:3582104|PMID:15992544

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern