Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SOS1
  • Mouse genes Sos1
  • Rat genes Sos1
  • Zfish genes sos1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sos1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Sos1	IPI	RGD:2543	Rat	PMID:26442853|RGD:155630597
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	SOS1	EXP		Human	PMID:1371879
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	SOS1	EXP		Human	PMID:16483568
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	SOS1	EXP		Human	PMID:7731718
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Sos1	EXP		Mouse	MGI:MGI:6214787|PMID:17721087
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Sos1	EXP		Mouse	MGI:MGI:3607660|PMID:16203968
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Sos1	EXP		Mouse	MGI:MGI:3613346|PMID:15644420
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Sos1	IMP	MGI:MGI:5141757	Mouse	PMID:29844066
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Sos1	IDA		Mouse	PMID:8479536
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Sos1	IMP		Mouse	PMID:11524436
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Sos1	IMP		Mouse	PMID:7799946
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Sos1	IDA		Mouse	PMID:7799946
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Sos1	IMP		Mouse	PMID:15728722
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:O43639	Human	PMID:10026169
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P16333	Human	PMID:10026169
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P16333	Human	PMID:10206341
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P08631	Human	PMID:12029088
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P20929	Human	PMID:12482578
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P62993	Human	PMID:12577067
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P01112	Human	PMID:12628188
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P62993	Human	PMID:14679214
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:Q9UKS6	Human	PMID:14679214
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:Q9Y5X1	Human	PMID:14679214
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P01112	Human	PMID:15507210
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P62993	Human	PMID:16520382
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P01112	Human	PMID:17084389
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P08631	Human	PMID:17141806
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P19174	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P27986	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P46108	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P62993	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P46108	Human	PMID:17515907
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P01112	Human	PMID:18454158
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P01112	Human	PMID:19141281
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P62993	Human	PMID:19323566
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P29353	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P46108	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:Q5TCZ1-2	Human	PMID:19464300
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P01112	Human	PMID:20133692
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P00533	Human	PMID:20473329
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P62993	Human	PMID:20473329
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P62993	Human	PMID:21706016
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P62993	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P08631	Human	PMID:23397142
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P27986	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P46108	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P00533	Human	PMID:26005835
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P62993	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:Q9UNS2	Human	PMID:30631038
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P46108	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P62993	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P57075-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P46108	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P62993	Human	PMID:7527391
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P62993	Human	PMID:7629138
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P62993	Human	PMID:7773779
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P19174	Human	PMID:9020117
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P01112	Human	PMID:9447984
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P62993	Human	PMID:9447984
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P29353	Human	PMID:9544989
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P62993	Human	PMID:9569023
Molecular Function	GO:0005515	protein binding	SOS1	IPI	UniProtKB:P01112	Human	PMID:9690470
Molecular Function	GO:0005515	protein binding	Sos1	IPI	UniProtKB:P62993|UniProtKB:Q60631	Mouse	MGI:MGI:5447634|PMID:9569023
Molecular Function	GO:0005515	protein binding	Sos1	IPI	UniProtKB:P62993-1	Mouse	MGI:MGI:5508625|PMID:16906159
Molecular Function	GO:0005515	protein binding	Sos1	IPI	UniProtKB:Q08509	Mouse	MGI:MGI:5486573|PMID:11524436
Molecular Function	GO:0005515	protein binding	Sos1	IPI	UniProtKB:P29355	Mouse	MGI:MGI:5508277|PMID:14978303
Molecular Function	GO:0005515	protein binding	Sos1	IPI	UniProtKB:Q60631	Mouse	MGI:MGI:5508324|PMID:8479540
Molecular Function	GO:0005515	protein binding	Sos1	IPI	UniProtKB:P26663	Mouse	MGI:MGI:5508270|PMID:15767257
Molecular Function	GO:0005515	protein binding	Sos1	IPI	UniProtKB:Q60631	Mouse	MGI:MGI:5553227|PMID:23452850
Molecular Function	GO:0005515	protein binding	Sos1	IPI	UniProtKB:P62993	Mouse	MGI:MGI:5516189|PMID:8940013
Molecular Function	GO:0005515	protein binding	Sos1	IPI	PR:Q91YX0	Mouse	PMID:22732588
Molecular Function	GO:0005515	protein binding	Sos1	IPI	PR:P29351	Mouse	PMID:8632004
Molecular Function	GO:0005515	protein binding	Sos1	IPI	PR:Q8BGW0	Mouse	PMID:22732588
Molecular Function	GO:0005515	protein binding	Sos1	IPI	PR:Q9WTP2	Mouse	PMID:16339969
Molecular Function	GO:0005515	protein binding	Sos1	IPI	PR:Q8C180	Mouse	PMID:9182757
Molecular Function	GO:0017124	SH3 domain binding	Sos1	IPI	RGD:3347	Rat	PMID:10913276|RGD:1581107
Cellular Component	GO:0005737	cytoplasm	SOS1	IDA		Human	PMID:17515907
Cellular Component	GO:1905360	GTPase complex	SOS1	IPI		Human	PMID:25695162
Cellular Component	GO:0043025	neuronal cell body	Sos1	IDA		Rat	PMID:15728722|RGD:1581104
Cellular Component	GO:0005886	plasma membrane	Sos1	IDA		Rat	PMID:9135150|RGD:1581109
Cellular Component	GO:0014069	postsynaptic density	Sos1	IDA		Rat	PMID:10517950|RGD:1581108
Biological Process	GO:0001782	B cell homeostasis	Sos1	IGI	MGI:MGI:98355	Mouse	PMID:24043312
Biological Process	GO:0050853	B cell receptor signaling pathway	Sos1	IGI	MGI:MGI:98355	Mouse	PMID:24043312
Biological Process	GO:0048514	blood vessel morphogenesis	Sos1	IMP	MGI:MGI:2155441	Mouse	PMID:9030684
Biological Process	GO:0003209	cardiac atrium morphogenesis	Sos1	IMP	MGI:MGI:2155441	Mouse	PMID:9030684
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Sos1	IMP	MGI:MGI:2155441	Mouse	PMID:9030684
Biological Process	GO:0061029	eyelid development in camera-type eye	Sos1	IGI	MGI:MGI:95294	Mouse	PMID:9030684
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Sos1	IGI	UniProtKB:Q9UC54	Mouse	PMID:11585837
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Sos1	IGI	MGI:MGI:1100860	Mouse	PMID:11585837
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Sos1	IGI	MGI:MGI:95805	Mouse	PMID:11585837
Biological Process	GO:0001942	hair follicle development	Sos1	IGI	MGI:MGI:95294	Mouse	PMID:9030684
Biological Process	GO:0003007	heart morphogenesis	Sos1	IMP	MGI:MGI:2155441	Mouse	PMID:9030684
Biological Process	GO:0061384	heart trabecula morphogenesis	Sos1	IMP	MGI:MGI:2155441	Mouse	PMID:9030684
Biological Process	GO:0008286	insulin receptor signaling pathway	Sos1	IDA		Mouse	PMID:8828504
Biological Process	GO:0008286	insulin receptor signaling pathway	Sos1	IDA		Mouse	PMID:7829473
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Sos1	IDA		Mouse	PMID:33567274
Biological Process	GO:0002260	lymphocyte homeostasis	Sos1	IGI	MGI:MGI:98355	Mouse	PMID:24043312
Biological Process	GO:1904693	midbrain morphogenesis	Sos1	IMP	MGI:MGI:2155441	Mouse	PMID:9030684
Biological Process	GO:0035264	multicellular organism growth	Sos1	IMP	MGI:MGI:2155441	Mouse	PMID:9030684
Biological Process	GO:0048011	neurotrophin TRK receptor signaling pathway	Sos1	IMP		Rat	PMID:15728722|RGD:1581104
Biological Process	GO:0003344	pericardium morphogenesis	Sos1	IMP	MGI:MGI:2155441	Mouse	PMID:9030684
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	Sos1	IEP		Rat	PMID:8577724|RGD:1581110
Biological Process	GO:0051057	positive regulation of small GTPase mediated signal transduction	Sos1	IMP		Rat	PMID:20219970|RGD:5686649
Biological Process	GO:0007265	Ras protein signal transduction	SOS1	IDA		Human	PMID:23027131
Biological Process	GO:0007265	Ras protein signal transduction	Sos1	IMP		Rat	PMID:15728722|RGD:1581104
Biological Process	GO:0042127	regulation of cell population proliferation	SOS1	IDA		Human	PMID:9054499
Biological Process	GO:0043405	regulation of MAP kinase activity	SOS1	IDA		Human	PMID:23027131
Biological Process	GO:2000973	regulation of pro-B cell differentiation	Sos1	IGI	MGI:MGI:98355	Mouse	PMID:24043312
Biological Process	GO:0033081	regulation of T cell differentiation in thymus	Sos1	IGI	MGI:MGI:98355	Mouse	PMID:24043312
Biological Process	GO:0042129	regulation of T cell proliferation	Sos1	IGI	MGI:MGI:98355	Mouse	PMID:24043312
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	SOS1	IDA		Human	PMID:23027131
Biological Process	GO:0002931	response to ischemia	Sos1	IDA		Rat	PMID:26442853|RGD:155630597
Biological Process	GO:0060021	roof of mouth development	Sos1	IMP	MGI:MGI:2155441	Mouse	PMID:9030684
Biological Process	GO:0007264	small GTPase mediated signal transduction	Sos1	IMP		Mouse	PMID:15728722
Biological Process	GO:0007296	vitellogenesis	Sos1	IMP	MGI:MGI:2155441	Mouse	PMID:9030684

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern