Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SOST
  • Mouse genes Sost
  • Rat genes Sost
  • Zfish genes sost
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sost

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030246	carbohydrate binding	SOST	EXP		Human	PMID:19208630
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SOST	IDA		Human	PMID:17696759
Molecular Function	GO:0140678	molecular function inhibitor activity	SOST	EXP		Human	PMID:19208630
Molecular Function	GO:0140678	molecular function inhibitor activity	SOST	EXP		Human	PMID:21944579
Molecular Function	GO:0140678	molecular function inhibitor activity	SOST	IPI	UniProtKB:O75581	Human	PMID:21944579
Molecular Function	GO:0005515	protein binding	SOST	IPI	UniProtKB:O75197	Human	PMID:15908424
Molecular Function	GO:0005515	protein binding	SOST	IPI	UniProtKB:O75581	Human	PMID:15908424
Molecular Function	GO:0005515	protein binding	SOST	IPI	UniProtKB:O75096	Human	PMID:21471202
Molecular Function	GO:0005515	protein binding	SOST	IPI	UniProtKB:O75197	Human	PMID:21471202
Molecular Function	GO:0005515	protein binding	SOST	IPI	UniProtKB:O75581	Human	PMID:21471202
Molecular Function	GO:0005515	protein binding	SOST	IPI	UniProtKB:O75581	Human	PMID:21944579
Molecular Function	GO:0005515	protein binding	SOST	IPI	UniProtKB:O75096	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SOST	IPI	UniProtKB:O75197	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SOST	IPI	UniProtKB:O75581	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SOST	IPI	UniProtKB:Q9H8W4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Sost	IPI	PR:P23611	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Sost	IPI	UniProtKB:O75197	Mouse	PMID:17002572
Molecular Function	GO:0005515	protein binding	Sost	IPI	UniProtKB:O75581	Mouse	PMID:17002572
Molecular Function	GO:0005515	protein binding	Sost	IPI	RGD:3183	Rat	PMID:15199066|RGD:1599074
Cellular Component	GO:0062023	collagen-containing extracellular matrix	SOST	HDA		Human	PMID:20551380
Cellular Component	GO:0005615	extracellular space	Sost	IDA		Rat	PMID:15199066|RGD:1599074
Cellular Component	GO:0005794	Golgi apparatus	Sost	IDA		Rat	PMID:17696759|RGD:8553739
Cellular Component	GO:0032991	protein-containing complex	Sost	IDA		Rat	PMID:15199066|RGD:1599074
Biological Process	GO:0030509	BMP signaling pathway	Sost	IDA		Mouse	PMID:17002572
Biological Process	GO:0060070	canonical Wnt signaling pathway	Sost	IGI	MGI:MGI:98956	Mouse	PMID:19896444
Biological Process	GO:0060070	canonical Wnt signaling pathway	Sost	IGI	MGI:MGI:1298218	Mouse	PMID:20359476
Biological Process	GO:0071374	cellular response to parathyroid hormone stimulus	SOST	IDA		Human	PMID:17696759
Biological Process	GO:0051179	localization	SOST	IEP		Human	PMID:19208630
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	SOST	IDA		Human	PMID:14633986
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Sost	IDA		Mouse	PMID:17002572
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	SOST	IDA		Human	PMID:15908424
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Sost	IGI	MGI:MGI:98956	Mouse	PMID:19896444
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Sost	IGI	MGI:MGI:1298218	Mouse	PMID:20359476
Biological Process	GO:0030279	negative regulation of ossification	Sost	IMP	MGI:MGI:5544793	Mouse	PMID:23918385
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	SOST	IDA		Human	PMID:15908424
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Sost	IDA		Mouse	PMID:17002572
Biological Process	GO:0001503	ossification	Sost	IDA		Mouse	PMID:14633986
Biological Process	GO:0001503	ossification	Sost	IEP		Rat	PMID:15199066|RGD:1599074
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	SOST	IMP		Human	PMID:17696759
Biological Process	GO:0009612	response to mechanical stimulus	SOST	IEP		Human	PMID:21723865

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern