Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SOX1
  • Mouse genes Sox1
  • Rat genes
  • Zfish genes sox1a,sox1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sox1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Sox1	IDA		Mouse	MGI:MGI:3044333|PMID:15110721
Molecular Function	GO:0003677	DNA binding	Sox1	IDA		Mouse	PMID:8625802
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Sox1	IDA		Mouse	MGI:MGI:1201714|PMID:9512512
Molecular Function	GO:0003700	DNA-binding transcription factor activity	sox1a	IDA		Zfish	PMID:16408288
Molecular Function	GO:0003700	DNA-binding transcription factor activity	sox1b	IDA		Zfish	PMID:16408288
Molecular Function	GO:0005515	protein binding	SOX1	IPI	UniProtKB:P40763	Human	PMID:20929579
Molecular Function	GO:0005515	protein binding	Sox1	IPI	UniProtKB:P35222|UniProtKB:Q02248	Mouse	MGI:MGI:3044333|PMID:15110721
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SOX1	IDA		Human	PMID:20049565
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Sox1	IDA		Mouse	MGI:MGI:1201714|PMID:9512512
Molecular Function	GO:0043565	sequence-specific DNA binding	Sox1	IDA		Mouse	PMID:9512512
Cellular Component	GO:0005634	nucleus	Sox1	IDA		Mouse	PMID:9512512
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Sox1	IDA		Mouse	PMID:20439489
Biological Process	GO:0007368	determination of left/right symmetry	sox1a	IMP	ZFIN:ZDB-GENO-200530-2	Zfish	PMID:31373552
Biological Process	GO:0030900	forebrain development	Sox1	IMP	MGI:MGI:2137412	Mouse	PMID:15882093
Biological Process	GO:0021884	forebrain neuron development	Sox1	IMP	MGI:MGI:2137412	Mouse	PMID:15882093
Biological Process	GO:0021879	forebrain neuron differentiation	Sox1	IMP	MGI:MGI:2137412	Mouse	PMID:15882093
Biological Process	GO:1904936	interneuron migration	Sox1	IMP		Mouse	MGI:MGI:4834949|PMID:20844123
Biological Process	GO:0002089	lens morphogenesis in camera-type eye	Sox1	IMP	MGI:MGI:2137412	Mouse	PMID:9512512
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Sox1	IMP		Mouse	MGI:MGI:3044333|PMID:15110721
Biological Process	GO:0001764	neuron migration	Sox1	IMP	MGI:MGI:2137412	Mouse	PMID:15882093
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	sox1a	IDA		Zfish	PMID:16408288
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	sox1b	IDA		Zfish	PMID:16408288
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Sox1	IDA		Mouse	MGI:MGI:1201714|PMID:9512512
Biological Process	GO:0048713	regulation of oligodendrocyte differentiation	Sox1	IMP		Mouse	MGI:MGI:4414895|PMID:19723505
Biological Process	GO:0021521	ventral spinal cord interneuron specification	Sox1	IMP	MGI:MGI:3653406	Mouse	PMID:20844123

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern