Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SOX17
  • Mouse genes Sox17
  • Rat genes Sox17
  • Zfish genes sox17
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sox17

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	SOX17	IPI	UniProtKB:P35222	Human	PMID:17875931
Molecular Function	GO:0003677	DNA binding	Sox17	IDA		Mouse	PMID:15082719
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Sox17	IDA		Mouse	PMID:8636240
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Sox17	IDA		Mouse	PMID:25209250
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Sox17	IDA		Mouse	PMID:19515696
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Sox17	IDA		Mouse	PMID:22344693
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Sox17	IDA		Mouse	PMID:15220343
Molecular Function	GO:0005515	protein binding	SOX17	IPI	UniProtKB:P35222	Human	PMID:17875931
Molecular Function	GO:0005515	protein binding	Sox17	IPI	UniProtKB:P27782|UniProtKB:Q02248	Mouse	MGI:MGI:4887291|PMID:20802155
Molecular Function	GO:0005515	protein binding	Sox17	IPI	UniProtKB:P15884|UniProtKB:P26233|UniProtKB:Q01978	Mouse	MGI:MGI:3768575|PMID:17875931
Molecular Function	GO:0005515	protein binding	Sox17	IPI	PR:P20263	Mouse	PMID:22344693
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	SOX17	IPI	UniProtKB:Q9NQB0	Human	PMID:17875931
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	SOX17	IPI	UniProtKB:Q01860-1	Human	PMID:19736317
Molecular Function	GO:0043565	sequence-specific DNA binding	Sox17	IDA		Mouse	PMID:8636240
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Sox17	IDA		Mouse	MGI:MGI:4887291|PMID:20802155
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Sox17	IDA		Mouse	MGI:MGI:4887547|PMID:19328208
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Sox17	IDA		Mouse	PMID:19515696
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Sox17	IDA		Mouse	PMID:20123909
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Sox17	IDA		Mouse	PMID:8636240
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Sox17	IDA		Mouse	PMID:25209250
Cellular Component	GO:0005634	nucleus	SOX17	IDA		Human	PMID:17875931
Cellular Component	GO:0005634	nucleus	SOX17	IDA		Human	PMID:18682240
Cellular Component	GO:0005634	nucleus	Sox17	IDA		Mouse	MGI:MGI:3768575|PMID:17875931
Cellular Component	GO:0005634	nucleus	Sox17	IDA		Mouse	PMID:16574095
Cellular Component	GO:0005634	nucleus	Sox17	IDA		Mouse	PMID:20123909
Cellular Component	GO:0005634	nucleus	Sox17	IDA		Mouse	PMID:23824537
Cellular Component	GO:0005634	nucleus	Sox17	IDA		Mouse	PMID:21146513
Cellular Component	GO:0005634	nucleus	Sox17	IDA		Mouse	PMID:8636240
Cellular Component	GO:0005667	transcription regulator complex	SOX17	IDA		Human	PMID:19736317
Cellular Component	GO:0005667	transcription regulator complex	Sox17	IDA		Mouse	PMID:22344693
Biological Process	GO:0001525	angiogenesis	Sox17	IGI	MGI:MGI:103559	Mouse	PMID:16895970
Biological Process	GO:0060913	cardiac cell fate determination	SOX17	IMP		Human	PMID:19736317
Biological Process	GO:0003142	cardiogenic plate morphogenesis	Sox17	IMP		Mouse	MGI:MGI:4946573|PMID:21305474
Biological Process	GO:0042074	cell migration involved in gastrulation	Sox17	IMP	MGI:MGI:3717121	Mouse	PMID:21146513
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Sox17	IDA		Mouse	PMID:20439489
Biological Process	GO:0061009	common bile duct development	Sox17	IMP		Mouse	PMID:19913509
Biological Process	GO:0061371	determination of heart left/right asymmetry	sox17	IMP	ZFIN:ZDB-MRPHLNO-101116-2	Zfish	PMID:20925124
Biological Process	GO:0035469	determination of pancreatic left/right asymmetry	sox17	IMP	ZFIN:ZDB-MRPHLNO-101116-2	Zfish	PMID:20925124
Biological Process	GO:0048617	embryonic foregut morphogenesis	Sox17	IMP		Mouse	MGI:MGI:4946573|PMID:21305474
Biological Process	GO:0048617	embryonic foregut morphogenesis	Sox17	IMP	MGI:MGI:4356113	Mouse	PMID:19619492
Biological Process	GO:0048617	embryonic foregut morphogenesis	Sox17	IMP	MGI:MGI:2179440	Mouse	PMID:18462699
Biological Process	GO:0048617	embryonic foregut morphogenesis	Sox17	IMP	MGI:MGI:3717118	Mouse	PMID:19619492
Biological Process	GO:0035050	embryonic heart tube development	Sox17	IGI	MGI:MGI:103559	Mouse	PMID:17610846
Biological Process	GO:0003143	embryonic heart tube morphogenesis	Sox17	IMP		Mouse	MGI:MGI:4946573|PMID:21305474
Biological Process	GO:0048568	embryonic organ development	Sox17	IMP	MGI:MGI:2179440	Mouse	PMID:19913509
Biological Process	GO:0060956	endocardial cell differentiation	Sox17	IGI	MGI:MGI:103559	Mouse	PMID:17610846
Biological Process	GO:0060214	endocardium formation	Sox17	IGI	MGI:MGI:103559	Mouse	PMID:17610846
Biological Process	GO:0007492	endoderm development	Sox17	IMP		Mouse	MGI:MGI:2178090|PMID:11973269
Biological Process	GO:0007492	endoderm development	Sox17	IMP	MGI:MGI:3717121	Mouse	PMID:21146513
Biological Process	GO:0007492	endoderm development	Sox17	IMP	MGI:MGI:2179440	Mouse	PMID:19913509
Biological Process	GO:0001706	endoderm formation	SOX17	IDA		Human	PMID:18682240
Biological Process	GO:0035987	endodermal cell differentiation	Sox17	IDA		Mouse	PMID:17940068
Biological Process	GO:0007493	endodermal cell fate determination	Sox17	IDA		Mouse	PMID:20308546
Biological Process	GO:0001714	endodermal cell fate specification	Sox17	IMP		Mouse	MGI:MGI:4946573|PMID:21305474
Biological Process	GO:0061031	endodermal digestive tract morphogenesis	Sox17	IMP		Mouse	MGI:MGI:4946573|PMID:21305474
Biological Process	GO:0061010	gallbladder development	Sox17	IMP	MGI:MGI:2179440	Mouse	PMID:19913509
Biological Process	GO:0007369	gastrulation	Sox17	IMP	MGI:MGI:3717118	Mouse	PMID:20123909
Biological Process	GO:0010467	gene expression	Sox17	IMP		Mouse	PMID:17940068
Biological Process	GO:0010467	gene expression	Sox17	IMP	MGI:MGI:3717118	Mouse	PMID:20123909
Biological Process	GO:0001947	heart looping	Sox17	IMP		Mouse	MGI:MGI:3716378|PMID:17655922
Biological Process	GO:0001947	heart looping	Sox17	IMP	MGI:MGI:2179440	Mouse	PMID:17610846
Biological Process	GO:0001828	inner cell mass cellular morphogenesis	Sox17	IMP	MGI:MGI:3717121	Mouse	PMID:21146513
Biological Process	GO:0070121	Kupffer's vesicle development	sox17	IMP	ZFIN:ZDB-MRPHLNO-101116-2	Zfish	PMID:20925124
Biological Process	GO:0001656	metanephros development	SOX17	IMP		Human	PMID:20960469
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	SOX17	IMP		Human	PMID:18413743
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	SOX17	IMP		Human	PMID:20960469
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Sox17	IMP		Mouse	MGI:MGI:3768575|PMID:17875931
Biological Process	GO:0030308	negative regulation of cell growth	SOX17	IMP		Human	PMID:18413743
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Sox17	IDA		Mouse	MGI:MGI:4887291|PMID:20802155
Biological Process	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development	Sox17	IMP		Mouse	MGI:MGI:3703823|PMID:17360443
Biological Process	GO:0003151	outflow tract morphogenesis	Sox17	IGI	UniProtKB:P43680	Mouse	MGI:MGI:3716256|PMID:17610846
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Sox17	IDA		Mouse	PMID:19515696
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Sox17	IDA		Mouse	PMID:15220343
Biological Process	GO:1903226	positive regulation of endodermal cell differentiation	Sox17	IDA		Mouse	PMID:17940068
Biological Process	GO:0010628	positive regulation of gene expression	Sox17	IMP		Mouse	PMID:17940068
Biological Process	GO:0010628	positive regulation of gene expression	Sox17	IMP	MGI:MGI:3717118	Mouse	PMID:20123909
Biological Process	GO:0045732	positive regulation of protein catabolic process	Sox17	IDA		Mouse	MGI:MGI:4887291|PMID:20802155
Biological Process	GO:2000738	positive regulation of stem cell differentiation	Sox17	IMP	MGI:MGI:3717118	Mouse	PMID:20123909
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SOX17	IDA		Human	PMID:22292085
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Sox17	IDA		Mouse	PMID:8636240
Biological Process	GO:0060215	primitive hemopoiesis	sox17	IMP	ZFIN:ZDB-MRPHLNO-160415-1	Zfish	PMID:21726513
Biological Process	GO:0031648	protein destabilization	SOX17	IMP		Human	PMID:17875931
Biological Process	GO:0050821	protein stabilization	SOX17	IMP		Human	PMID:17875931
Biological Process	GO:2000043	regulation of cardiac cell fate specification	Sox17	IMP		Mouse	MGI:MGI:3703823|PMID:17360443
Biological Process	GO:0045595	regulation of cell differentiation	Sox17	IMP	MGI:MGI:3717121	Mouse	PMID:21146513
Biological Process	GO:0006355	regulation of DNA-templated transcription	Sox17	IDA		Mouse	MGI:MGI:4887291|PMID:20802155
Biological Process	GO:0045995	regulation of embryonic development	Sox17	IMP		Mouse	MGI:MGI:2178090|PMID:11973269
Biological Process	GO:2000035	regulation of stem cell division	Sox17	IMP	MGI:MGI:3717118	Mouse	PMID:20123909
Biological Process	GO:0072091	regulation of stem cell proliferation	Sox17	IDA		Mouse	PMID:20228271
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Sox17	IMP		Mouse	MGI:MGI:4946573|PMID:21305474
Biological Process	GO:0021903	rostrocaudal neural tube patterning	Sox17	IMP	MGI:MGI:2179440	Mouse	PMID:19913509
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	Sox17	IDA		Mouse	PMID:18462699
Biological Process	GO:0007283	spermatogenesis	Sox17	IDA		Mouse	PMID:8636240
Biological Process	GO:0048863	stem cell differentiation	Sox17	IMP	MGI:MGI:3717118	Mouse	PMID:20123909
Biological Process	GO:0048866	stem cell fate specification	Sox17	IDA		Mouse	PMID:20228271
Biological Process	GO:0072189	ureter development	SOX17	IMP		Human	PMID:20960469
Biological Process	GO:0001570	vasculogenesis	Sox17	IGI	MGI:MGI:103559	Mouse	PMID:16895970

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern