Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SOX18
  • Mouse genes Sox18
  • Rat genes Sox18
  • Zfish genes sox18
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sox18

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Sox18	IDA		Mouse	PMID:12446692
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	SOX18	IDA		Human	PMID:22292085
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Sox18	IDA		Mouse	PMID:12446692
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Sox18	IDA		Mouse	PMID:14634005
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Sox18	IDA		Mouse	PMID:7651823
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Sox18	IDA		Mouse	PMID:10742113
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Sox18	IDA		Mouse	PMID:22344693
Molecular Function	GO:0005515	protein binding	Sox18	IPI	UniProtKB:Q8CFN5	Mouse	MGI:MGI:5142376|PMID:11554755
Molecular Function	GO:0005515	protein binding	Sox18	IPI	PR:P20263	Mouse	PMID:22344693
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SOX18	IDA		Human	PMID:22292085
Molecular Function	GO:0043565	sequence-specific DNA binding	Sox18	IDA		Mouse	PMID:7651823
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	SOX18	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	SOX18	IDA		Human	PMID:18065521
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Sox18	IDA		Mouse	PMID:14634005
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Sox18	IDA		Mouse	PMID:18931657
Cellular Component	GO:0000785	chromatin	SOX18	IDA		Human	PMID:22292085
Cellular Component	GO:0005634	nucleus	SOX18	IDA		Human	PMID:18065521
Cellular Component	GO:0005634	nucleus	Sox18	IDA		Mouse	MGI:MGI:5142376|PMID:11554755
Cellular Component	GO:0005634	nucleus	Sox18	IDA		Mouse	PMID:18931657
Cellular Component	GO:0005667	transcription regulator complex	Sox18	IDA		Mouse	PMID:22344693
Biological Process	GO:0001525	angiogenesis	SOX18	IEP		Human	PMID:16882943
Biological Process	GO:0001525	angiogenesis	Sox18	IGI	MGI:MGI:107543	Mouse	PMID:16895970
Biological Process	GO:0060840	artery development	sox18	IGI	ZFIN:ZDB-MRPHLNO-060626-6,ZFIN:ZDB-MRPHLNO-081022-1,ZFIN:ZDB-MRPHLNO-081022-2	Zfish	PMID:23818617
Biological Process	GO:0001568	blood vessel development	Sox18	IMP	MGI:MGI:1856135	Mouse	PMID:10742113
Biological Process	GO:0001568	blood vessel development	Sox18	IMP	MGI:MGI:1856136	Mouse	PMID:19429912
Biological Process	GO:0001568	blood vessel development	sox18	IGI	ZFIN:ZDB-GENE-040109-4	Zfish	PMID:25834021
Biological Process	GO:0001568	blood vessel development	sox18	IGI	ZFIN:ZDB-MRPHLNO-080725-1,ZFIN:ZDB-MRPHLNO-151020-4	Zfish	PMID:24269955
Biological Process	GO:0043534	blood vessel endothelial cell migration	SOX18	IEP		Human	PMID:16882943
Biological Process	GO:0048469	cell maturation	Sox18	IDA		Mouse	PMID:20228271
Biological Process	GO:0035050	embryonic heart tube development	Sox18	IGI	MGI:MGI:107543	Mouse	PMID:17610846
Biological Process	GO:0060956	endocardial cell differentiation	Sox18	IGI	MGI:MGI:107543	Mouse	PMID:17610846
Biological Process	GO:0060214	endocardium formation	Sox18	IGI	MGI:MGI:107543	Mouse	PMID:17610846
Biological Process	GO:0061028	establishment of endothelial barrier	SOX18	IMP		Human	PMID:18065521
Biological Process	GO:0022405	hair cycle process	SOX18	IMP		Human	PMID:12740761
Biological Process	GO:0001942	hair follicle development	Sox18	IMP	MGI:MGI:2178809	Mouse	PMID:11094083
Biological Process	GO:0001942	hair follicle development	Sox18	IMP	MGI:MGI:1856135	Mouse	PMID:10742113
Biological Process	GO:0007507	heart development	Sox18	IMP	MGI:MGI:1856135	Mouse	PMID:10742113
Biological Process	GO:0001701	in utero embryonic development	Sox18	IMP	MGI:MGI:2178809	Mouse	PMID:18931657
Biological Process	GO:0001701	in utero embryonic development	Sox18	IMP	MGI:MGI:1856136	Mouse	PMID:19429912
Biological Process	GO:0001701	in utero embryonic development	Sox18	IMP	MGI:MGI:1856135	Mouse	PMID:10742113
Biological Process	GO:0001945	lymph vessel development	Sox18	IMP	MGI:MGI:2178809	Mouse	PMID:19515696
Biological Process	GO:0001945	lymph vessel development	Sox18	IMP	MGI:MGI:1856135	Mouse	PMID:291594
Biological Process	GO:0001946	lymphangiogenesis	SOX18	IMP		Human	PMID:12740761
Biological Process	GO:0001946	lymphangiogenesis	Sox18	IMP	MGI:MGI:2178809	Mouse	PMID:18931657
Biological Process	GO:0001946	lymphangiogenesis	sox18	IMP		Zfish	PMID:23520166
Biological Process	GO:0060836	lymphatic endothelial cell differentiation	Sox18	IMP	MGI:MGI:2178809	Mouse	PMID:18931657
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Sox18	IDA		Mouse	PMID:18931657
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SOX18	IDA		Human	PMID:22292085
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Sox18	IDA		Mouse	MGI:MGI:5142376|PMID:11554755
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Sox18	IDA		Mouse	PMID:10742113
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Sox18	IDA		Mouse	PMID:18931657
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Sox18	IDA		Mouse	PMID:11179689
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Sox18	IDA		Mouse	PMID:14634005
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Sox18	IDA		Mouse	PMID:7651823
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SOX18	IDA		Human	PMID:18065521
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SOX18	IDA		Human	PMID:22292085
Biological Process	GO:0006355	regulation of DNA-templated transcription	Sox18	IDA		Mouse	PMID:12446692
Biological Process	GO:0072091	regulation of stem cell proliferation	Sox18	IDA		Mouse	PMID:20228271
Biological Process	GO:0048866	stem cell fate specification	Sox18	IDA		Mouse	PMID:20228271
Biological Process	GO:0001944	vasculature development	Sox18	IMP	MGI:MGI:1856136	Mouse	PMID:19429912
Biological Process	GO:0001570	vasculogenesis	Sox18	IGI	MGI:MGI:107543	Mouse	PMID:16895970
Biological Process	GO:0001570	vasculogenesis	sox18	IGI	ZFIN:ZDB-GENE-040109-4	Zfish	PMID:28619820
Biological Process	GO:0001570	vasculogenesis	sox18	IGI	ZFIN:ZDB-MRPHLNO-081022-5,ZFIN:ZDB-MRPHLNO-081022-6	Zfish	PMID:18094332
Biological Process	GO:0001570	vasculogenesis	sox18	IGI	ZFIN:ZDB-MRPHLNO-080811-1,ZFIN:ZDB-MRPHLNO-080811-3	Zfish	PMID:18377889
Biological Process	GO:0001570	vasculogenesis	sox18	IGI	ZFIN:ZDB-MRPHLNO-081022-3,ZFIN:ZDB-MRPHLNO-081022-4	Zfish	PMID:18094332
Biological Process	GO:0001570	vasculogenesis	sox18	IGI	ZFIN:ZDB-MRPHLNO-081022-1,ZFIN:ZDB-MRPHLNO-081022-2	Zfish	PMID:21726513
Biological Process	GO:0001570	vasculogenesis	sox18	IGI	ZFIN:ZDB-MRPHLNO-081022-1,ZFIN:ZDB-MRPHLNO-081022-2	Zfish	PMID:18094332
Biological Process	GO:0001570	vasculogenesis	sox18	IGI	ZFIN:ZDB-MRPHLNO-080811-2,ZFIN:ZDB-MRPHLNO-080811-4	Zfish	PMID:18377889
Biological Process	GO:0001570	vasculogenesis	sox18	IGI	ZFIN:ZDB-MRPHLNO-080725-1,ZFIN:ZDB-MRPHLNO-080725-2	Zfish	PMID:18032732
Biological Process	GO:0001570	vasculogenesis	sox18	IGI	ZFIN:ZDB-MRPHLNO-081022-1,ZFIN:ZDB-MRPHLNO-081022-2	Zfish	PMID:21730073

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern