Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SOX21
  • Mouse genes Sox21
  • Rat genes
  • Zfish genes sox21a,sox21b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sox21

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Sox21	IDA		Mouse	PMID:12446692
Molecular Function	GO:0003677	DNA binding	sox21a	IMP		Zfish	PMID:15037315
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Sox21	IDA		Mouse	MGI:MGI:2449851|PMID:12446692
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Sox21	IDA		Mouse	PMID:12446692
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	sox21a	IMP		Zfish	PMID:15037315
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Sox21	IDA		Mouse	MGI:MGI:2449851|PMID:12446692
Biological Process	GO:0009953	dorsal/ventral pattern formation	sox21a	IMP		Zfish	PMID:15037315|ZFIN:ZDB-PUB-040220-1
Biological Process	GO:0009953	dorsal/ventral pattern formation	sox21a	IMP		Zfish	PMID:15037315
Biological Process	GO:0042633	hair cycle	Sox21	IMP	MGI:MGI:3849852	Mouse	PMID:19470461
Biological Process	GO:0001942	hair follicle development	Sox21	IMP	MGI:MGI:3849852	Mouse	PMID:19470461
Biological Process	GO:0002088	lens development in camera-type eye	sox21b	IMP	ZFIN:ZDB-MRPHLNO-120427-2	Zfish	PMID:22387845
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	sox21a	IDA		Zfish	PMID:15037315|ZFIN:ZDB-PUB-040220-1
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	sox21a	IDA		Zfish	PMID:15037315|ZFIN:ZDB-PUB-040220-1
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	sox21a	IMP		Zfish	PMID:15037315
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Sox21	IDA		Mouse	MGI:MGI:2449851|PMID:12446692
Biological Process	GO:0006355	regulation of DNA-templated transcription	Sox21	IDA		Mouse	PMID:12446692
Biological Process	GO:0048545	response to steroid hormone	sox21a	IEP		Zfish	PMID:28265462
Biological Process	GO:0043588	skin development	Sox21	IMP	MGI:MGI:3849852	Mouse	PMID:19470461
Biological Process	GO:0048863	stem cell differentiation	SOX21	IDA		Human	PMID:20876214

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern