Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SOX3
  • Mouse genes Sox3
  • Rat genes
  • Zfish genes sox3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sox3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Sox3	IDA		Mouse	PMID:8625802
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	sox3	IPI	ZFIN:ZDB-GENE-990415-43	Zfish	PMID:30588557
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	sox3	IMP		Zfish	PMID:30588557
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	sox3	IDA		Zfish	PMID:30588557
Molecular Function	GO:0003700	DNA-binding transcription factor activity	sox3	IDA		Zfish	PMID:16408288
Molecular Function	GO:0005515	protein binding	SOX3	IPI	UniProtKB:O43186	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SOX3	IPI	UniProtKB:P54253	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SOX3	IPI	UniProtKB:Q12933	Human	PMID:32296183
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Sox3	IDA		Mouse	MGI:MGI:5142371|PMID:11875113
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	SOX3	IDA		Human	PMID:28473536
Cellular Component	GO:0005654	nucleoplasm	SOX3	IDA		Human	GO_REF:0000052
Biological Process	GO:0009887	animal organ morphogenesis	Sox3	IMP	MGI:MGI:3036671	Mouse	PMID:14981518
Biological Process	GO:0007417	central nervous system development	sox3	IMP	ZFIN:ZDB-MRPHLNO-081113-1,ZFIN:ZDB-MRPHLNO-081113-2	Zfish	PMID:18572157
Biological Process	GO:0060324	face development	Sox3	IMP		Mouse	MGI:MGI:3765357|PMID:17728342
Biological Process	GO:0030900	forebrain development	Sox3	IMP	MGI:MGI:3036671	Mouse	PMID:14981518
Biological Process	GO:0021854	hypothalamus development	Sox3	IMP		Mouse	MGI:MGI:3033563|PMID:14981518
Biological Process	GO:0030182	neuron differentiation	sox3	IMP	ZFIN:ZDB-MRPHLNO-081113-1,ZFIN:ZDB-MRPHLNO-081113-2	Zfish	PMID:18572157
Biological Process	GO:1905040	otic placode development	sox3	IMP	ZFIN:ZDB-GENO-181105-2	Zfish	PMID:29355522
Biological Process	GO:0043049	otic placode formation	sox3	IMP	ZFIN:ZDB-MRPHLNO-100527-3	Zfish	PMID:21215261
Biological Process	GO:0043049	otic placode formation	sox3	IGI	ZFIN:ZDB-MRPHLNO-050208-1,ZFIN:ZDB-MRPHLNO-050208-2,ZFIN:ZDB-MRPHLNO-100527-3	Zfish	PMID:21215261
Biological Process	GO:0001541	ovarian follicle development	sox3	IMP		Zfish	PMID:30588557
Biological Process	GO:0007422	peripheral nervous system development	sox3	IMP	ZFIN:ZDB-MRPHLNO-100527-3	Zfish	PMID:21215261
Biological Process	GO:0007422	peripheral nervous system development	sox3	IGI	ZFIN:ZDB-MRPHLNO-050208-1,ZFIN:ZDB-MRPHLNO-050208-2,ZFIN:ZDB-MRPHLNO-100527-3	Zfish	PMID:21215261
Biological Process	GO:0021983	pituitary gland development	Sox3	IMP		Mouse	MGI:MGI:3033563|PMID:14981518
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	sox3	IDA		Zfish	PMID:16408288
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	sox3	IDA		Zfish	PMID:30588557
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	sox3	IMP		Zfish	PMID:30588557
Biological Process	GO:0007423	sensory organ development	Sox3	IMP		Mouse	MGI:MGI:3765357|PMID:17728342
Biological Process	GO:0060009	Sertoli cell development	Sox3	IEP		Mouse	MGI:MGI:5142371|PMID:11875113
Biological Process	GO:0007530	sex determination	SOX3	IMP		Human	PMID:21183788
Biological Process	GO:0007530	sex determination	Sox3	IMP		Mouse	MGI:MGI:5000178|PMID:21183788
Biological Process	GO:0048515	spermatid differentiation	Sox3	IMP	MGI:MGI:2682663	Mouse	PMID:15893302

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern