Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SOX4
  • Mouse genes Sox4
  • Rat genes
  • Zfish genes sox4a,sox4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sox4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Sox4	IDA		Mouse	MGI:MGI:5009531|PMID:18403418
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	SOX4	IDA		Human	PMID:19147588
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Sox4	IDA		Mouse	MGI:MGI:3803393|PMID:18505825
Molecular Function	GO:0003700	DNA-binding transcription factor activity	SOX4	IDA		Human	PMID:16631117
Molecular Function	GO:0003700	DNA-binding transcription factor activity	SOX4	IMP		Human	PMID:20049565
Molecular Function	GO:0003700	DNA-binding transcription factor activity	SOX4	IMP		Human	PMID:30661772
Molecular Function	GO:0003700	DNA-binding transcription factor activity	SOX4	IDA		Human	PMID:7706298
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Sox4	IDA		Mouse	MGI:MGI:5285123|PMID:21527504
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Sox4	IDA		Mouse	PMID:22344693
Molecular Function	GO:0035198	miRNA binding	Sox4	IDA		Mouse	PMID:26802803
Molecular Function	GO:0005515	protein binding	SOX4	IPI	UniProtKB:P63279	Human	PMID:16631117
Molecular Function	GO:0005515	protein binding	SOX4	IPI	UniProtKB:Q9Y2X9	Human	PMID:19147588
Molecular Function	GO:0005515	protein binding	SOX4	IPI	UniProtKB:P04637	Human	PMID:19234109
Molecular Function	GO:0005515	protein binding	SOX4	IPI	UniProtKB:Q09472	Human	PMID:19234109
Molecular Function	GO:0005515	protein binding	SOX4	IPI	UniProtKB:Q92793	Human	PMID:19234109
Molecular Function	GO:0005515	protein binding	SOX4	IDA		Human	PMID:26291311
Molecular Function	GO:0005515	protein binding	Sox4	IPI	UniProtKB:P15884	Mouse	MGI:MGI:3768575|PMID:17875931
Molecular Function	GO:0005515	protein binding	Sox4	IPI	PR:P20263	Mouse	PMID:22344693
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SOX4	IDA		Human	PMID:20049565
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Sox4	IDA		Mouse	MGI:MGI:5285157|PMID:20596238
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	SOX4	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Sox4	IDA		Mouse	MGI:MGI:3803393|PMID:18505825
Cellular Component	GO:0005737	cytoplasm	SOX4	IDA		Human	PMID:17875931
Cellular Component	GO:0005737	cytoplasm	Sox4	IDA		Mouse	PMID:26802803
Cellular Component	GO:0005739	mitochondrion	SOX4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SOX4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	SOX4	IDA		Human	PMID:16631117
Cellular Component	GO:0005634	nucleus	SOX4	IDA		Human	PMID:17875931
Cellular Component	GO:0005634	nucleus	SOX4	IDA		Human	PMID:19234109
Cellular Component	GO:0005634	nucleus	Sox4	IDA		Mouse	MGI:MGI:3768575|PMID:17875931
Cellular Component	GO:0005634	nucleus	Sox4	IDA		Mouse	PMID:16306355
Cellular Component	GO:0005634	nucleus	Sox4	IDA		Mouse	PMID:15645444
Cellular Component	GO:0005667	transcription regulator complex	Sox4	IDA		Mouse	PMID:22344693
Biological Process	GO:0035910	ascending aorta morphogenesis	Sox4	IMP		Mouse	MGI:MGI:3603061|PMID:16109771
Biological Process	GO:0003289	atrial septum primum morphogenesis	Sox4	IMP		Mouse	MGI:MGI:3603061|PMID:16109771
Biological Process	GO:0003215	cardiac right ventricle morphogenesis	Sox4	IMP		Mouse	MGI:MGI:3603061|PMID:16109771
Biological Process	GO:0003211	cardiac ventricle formation	Sox4	IMP		Mouse	MGI:MGI:5285157|PMID:20596238
Biological Process	GO:0071333	cellular response to glucose stimulus	Sox4	IMP		Mouse	MGI:MGI:3819280|PMID:18477811
Biological Process	GO:0061386	closure of optic fissure	sox4a	IGI	ZFIN:ZDB-GENE-040426-1274	Zfish	PMID:25557621
Biological Process	GO:0061386	closure of optic fissure	sox4a	IGI	ZFIN:ZDB-GENE-040426-1274,ZFIN:ZDB-GENE-980526-395,ZFIN:ZDB-GENE-980526-466	Zfish	PMID:25557621
Biological Process	GO:0061386	closure of optic fissure	sox4b	IGI	ZFIN:ZDB-GENE-030131-8290	Zfish	PMID:25557621
Biological Process	GO:0061386	closure of optic fissure	sox4b	IGI	ZFIN:ZDB-GENE-030131-8290,ZFIN:ZDB-GENE-980526-395,ZFIN:ZDB-GENE-980526-466	Zfish	PMID:25557621
Biological Process	GO:0031018	endocrine pancreas development	Sox4	IMP	MGI:MGI:2182092	Mouse	PMID:16306355
Biological Process	GO:0031018	endocrine pancreas development	sox4b	IMP	ZFIN:ZDB-MRPHLNO-051013-1	Zfish	PMID:16055112
Biological Process	GO:0010467	gene expression	Sox4	IDA		Mouse	PMID:31281513
Biological Process	GO:0021782	glial cell development	Sox4	IMP		Mouse	MGI:MGI:4838379|PMID:20646169
Biological Process	GO:0021782	glial cell development	Sox4	IMP		Mouse	MGI:MGI:4437361|PMID:20147379
Biological Process	GO:0014009	glial cell proliferation	Sox4	IMP		Mouse	MGI:MGI:4437361|PMID:20147379
Biological Process	GO:0042593	glucose homeostasis	Sox4	IMP		Mouse	MGI:MGI:3819280|PMID:18477811
Biological Process	GO:0007507	heart development	Sox4	IMP		Mouse	MGI:MGI:80229|PMID:8614465
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	Sox4	IMP		Mouse	PMID:26880577
Biological Process	GO:0060993	kidney morphogenesis	Sox4	IMP		Mouse	MGI:MGI:3603061|PMID:16109771
Biological Process	GO:0060174	limb bud formation	Sox4	IMP		Mouse	MGI:MGI:5285157|PMID:20596238
Biological Process	GO:0003183	mitral valve morphogenesis	Sox4	IMP		Mouse	MGI:MGI:3603061|PMID:16109771
Biological Process	GO:0060548	negative regulation of cell death	Sox4	IMP		Mouse	MGI:MGI:4838379|PMID:20646169
Biological Process	GO:0060548	negative regulation of cell death	Sox4	IMP		Mouse	MGI:MGI:5285157|PMID:20596238
Biological Process	GO:0008285	negative regulation of cell population proliferation	SOX4	IMP		Human	PMID:19234109
Biological Process	GO:0045662	negative regulation of myoblast differentiation	SOX4	IDA		Human	PMID:26291311
Biological Process	GO:0031397	negative regulation of protein ubiquitination	SOX4	IMP		Human	PMID:19234109
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	sox4a	IGI	ZFIN:ZDB-GENE-040426-1274	Zfish	PMID:25557621
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	sox4b	IGI	ZFIN:ZDB-GENE-030131-8290	Zfish	PMID:25557621
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SOX4	IDA		Human	PMID:26291311
Biological Process	GO:0001841	neural tube formation	Sox4	IMP		Mouse	MGI:MGI:5285157|PMID:20596238
Biological Process	GO:0060563	neuroepithelial cell differentiation	Sox4	IMP		Mouse	MGI:MGI:4838379|PMID:20646169
Biological Process	GO:0003357	noradrenergic neuron differentiation	Sox4	IMP		Mouse	MGI:MGI:4437361|PMID:20147379
Biological Process	GO:0043065	positive regulation of apoptotic process	SOX4	IMP		Human	PMID:15522200
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Sox4	IMP		Mouse	MGI:MGI:3768575|PMID:17875931
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Sox4	IDA		Mouse	MGI:MGI:3768575|PMID:17875931
Biological Process	GO:0008284	positive regulation of cell population proliferation	SOX4	IMP		Human	PMID:17875931
Biological Process	GO:0008284	positive regulation of cell population proliferation	Sox4	IMP		Mouse	MGI:MGI:5285157|PMID:20596238
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	SOX4	IDA		Human	PMID:16631117
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	SOX4	IDA		Human	PMID:19147588
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	SOX4	IMP		Human	PMID:19234109
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Sox4	IDA		Mouse	MGI:MGI:5285157|PMID:20596238
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Sox4	IDA		Mouse	MGI:MGI:5285123|PMID:21527504
Biological Process	GO:0045588	positive regulation of gamma-delta T cell differentiation	Sox4	IMP		Mouse	MGI:MGI:5486619|PMID:23562159
Biological Process	GO:0032024	positive regulation of insulin secretion	Sox4	IMP		Mouse	MGI:MGI:3819280|PMID:18477811
Biological Process	GO:0045663	positive regulation of myoblast differentiation	SOX4	IDA		Human	PMID:26291311
Biological Process	GO:0045663	positive regulation of myoblast differentiation	Sox4	IDA		Mouse	MGI:MGI:6838711|PMID:26291311
Biological Process	GO:2000761	positive regulation of N-terminal peptidyl-lysine acetylation	SOX4	IDA		Human	PMID:19234109
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SOX4	IDA		Human	PMID:19147588
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SOX4	IMP		Human	PMID:20049565
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SOX4	IDA		Human	PMID:26291311
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Sox4	IDA		Mouse	MGI:MGI:3803393|PMID:18505825
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Sox4	IDA		Mouse	MGI:MGI:5009531|PMID:18403418
Biological Process	GO:0045727	positive regulation of translation	SOX4	IMP		Human	PMID:19234109
Biological Process	GO:0002328	pro-B cell differentiation	Sox4	IMP		Mouse	MGI:MGI:80229|PMID:8614465
Biological Process	GO:0050821	protein stabilization	SOX4	IMP		Human	PMID:17875931
Biological Process	GO:0050821	protein stabilization	Sox4	IMP		Mouse	MGI:MGI:3768575|PMID:17875931
Biological Process	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	SOX4	IMP		Human	PMID:19234109
Biological Process	GO:0006355	regulation of DNA-templated transcription	SOX4	IDA		Human	PMID:16631117
Biological Process	GO:0006355	regulation of DNA-templated transcription	SOX4	IDA		Human	PMID:7706298
Biological Process	GO:0006355	regulation of DNA-templated transcription	Sox4	IMP		Mouse	MGI:MGI:5486619|PMID:23562159
Biological Process	GO:0031647	regulation of protein stability	SOX4	IMP		Human	PMID:19234109
Biological Process	GO:0001501	skeletal system development	Sox4	IMP		Mouse	MGI:MGI:5285157|PMID:20596238
Biological Process	GO:0035019	somatic stem cell population maintenance	Sox4	IDA		Mouse	PMID:19379700
Biological Process	GO:0021510	spinal cord development	Sox4	IMP		Mouse	MGI:MGI:4838379|PMID:20646169
Biological Process	GO:0021522	spinal cord motor neuron differentiation	Sox4	IMP		Mouse	MGI:MGI:4838379|PMID:20646169
Biological Process	GO:0048485	sympathetic nervous system development	Sox4	IMP		Mouse	MGI:MGI:4437361|PMID:20147379
Biological Process	GO:0030217	T cell differentiation	Sox4	IMP		Mouse	MGI:MGI:3813366|PMID:9174623
Biological Process	GO:0060412	ventricular septum morphogenesis	Sox4	IMP		Mouse	MGI:MGI:3603061|PMID:16109771

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern