Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SOX8
  • Mouse genes Sox8
  • Rat genes Sox8
  • Zfish genes sox8a,sox8b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sox8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	Sox8	IDA		Mouse	PMID:15102707
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	Sox8	IDA		Mouse	PMID:12732652
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Sox8	IDA		Mouse	PMID:10684944
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Sox8	IDA		Mouse	PMID:12732652
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Sox8	IMP	MGI:MGI:2154329	Mouse	PMID:17084361
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Sox8	IDA		Mouse	PMID:22344693
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Sox8	IPI	UniProtKB:F1LMV3|UniProtKB:P05554|UniProtKB:P08047|UniProtKB:P17325|UniProtKB:P51514|UniProtKB:P51774|UniProtKB:P63013|UniProtKB:Q06348|UniProtKB:Q08624|UniProtKB:Q9EQW6	Mouse	MGI:MGI:5284787|PMID:16582099
Molecular Function	GO:0005515	protein binding	Sox8	IPI	PR:P20263	Mouse	PMID:22344693
Molecular Function	GO:0005515	protein binding	Sox8	IPI	PR:P33242	Mouse	PMID:12732652
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Sox8	IDA		Mouse	MGI:MGI:5142371|PMID:11875113
Molecular Function	GO:0043565	sequence-specific DNA binding	Sox8	IDA		Mouse	PMID:10684944
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	SOX8	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	Sox8	IDA		Mouse	MGI:MGI:3527299|PMID:15572147
Cellular Component	GO:0005737	cytoplasm	Sox8	IMP	MGI:MGI:3795214	Mouse	PMID:18342849
Cellular Component	GO:0005634	nucleus	SOX8	IDA		Human	PMID:18512230
Cellular Component	GO:0005634	nucleus	Sox8	IDA		Mouse	PMID:12782625
Cellular Component	GO:0005634	nucleus	Sox8	IDA		Mouse	PMID:18342849
Cellular Component	GO:0005667	transcription regulator complex	Sox8	IDA		Mouse	PMID:22344693
Biological Process	GO:0060612	adipose tissue development	Sox8	IMP	MGI:MGI:2154329	Mouse	PMID:11564878
Biological Process	GO:0060612	adipose tissue development	Sox8	IMP	MGI:MGI:2154329	Mouse	PMID:19286648
Biological Process	GO:0060018	astrocyte fate commitment	Sox8	IGI	MGI:MGI:98371	Mouse	PMID:19490914
Biological Process	GO:0045165	cell fate commitment	Sox8	IGI	MGI:MGI:98371	Mouse	PMID:15893981
Biological Process	GO:0048469	cell maturation	Sox8	IGI	MGI:MGI:98358	Mouse	PMID:15102707
Biological Process	GO:0048469	cell maturation	Sox8	IMP	MGI:MGI:2154329	Mouse	PMID:15102707
Biological Process	GO:0048484	enteric nervous system development	Sox8	IMP		Mouse	MGI:MGI:3527299|PMID:15572147
Biological Process	GO:0045444	fat cell differentiation	Sox8	IMP	MGI:MGI:2154329	Mouse	PMID:19286648
Biological Process	GO:0001701	in utero embryonic development	Sox8	IGI	MGI:MGI:98358	Mouse	PMID:16790476
Biological Process	GO:0008584	male gonad development	Sox8	IGI	MGI:MGI:98371	Mouse	PMID:15056615
Biological Process	GO:0008584	male gonad development	Sox8	IGI	MGI:MGI:98371	Mouse	PMID:19124014
Biological Process	GO:0072289	metanephric nephron tubule formation	Sox8	IGI	MGI:MGI:98371	Mouse	PMID:21212101
Biological Process	GO:0061138	morphogenesis of a branching epithelium	Sox8	IGI	MGI:MGI:98371	Mouse	PMID:21212101
Biological Process	GO:0043066	negative regulation of apoptotic process	Sox8	IMP		Mouse	MGI:MGI:3527299|PMID:15572147
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Sox8	IMP		Mouse	MGI:MGI:4939090|PMID:21212101
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Sox8	IDA		Mouse	PMID:12782625
Biological Process	GO:0045662	negative regulation of myoblast differentiation	Sox8	IDA		Mouse	PMID:12782625
Biological Process	GO:0046533	negative regulation of photoreceptor cell differentiation	Sox8	IGI	MGI:MGI:98371	Mouse	PMID:19490914
Biological Process	GO:0001755	neural crest cell migration	Sox8	IMP		Mouse	MGI:MGI:3527299|PMID:15572147
Biological Process	GO:0048709	oligodendrocyte differentiation	Sox8	IMP	MGI:MGI:2154329	Mouse	PMID:17084361
Biological Process	GO:0001649	osteoblast differentiation	Sox8	IMP	MGI:MGI:2154329	Mouse	PMID:15753123
Biological Process	GO:0007422	peripheral nervous system development	Sox8	IGI	MGI:MGI:98358	Mouse	PMID:16790476
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Sox8	IMP		Mouse	MGI:MGI:4939090|PMID:21212101
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Sox8	IDA		Mouse	MGI:MGI:5142371|PMID:11875113
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Sox8	IDA		Mouse	MGI:MGI:5284787|PMID:16582099
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Sox8	IMP	MGI:MGI:2154329	Mouse	PMID:17084361
Biological Process	GO:0010628	positive regulation of gene expression	Sox8	IGI	MGI:MGI:98371	Mouse	PMID:19124014
Biological Process	GO:0014015	positive regulation of gliogenesis	Sox8	IMP		Mouse	MGI:MGI:3527299|PMID:15572147
Biological Process	GO:0090184	positive regulation of kidney development	Sox8	IGI	UniProtKB:Q04887	Mouse	MGI:MGI:4939090|PMID:21212101
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	Sox8	IMP	MGI:MGI:2154329	Mouse	PMID:15753123
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SOX8	IDA		Human	PMID:10662550
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Sox8	IDA		Mouse	PMID:10684944
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Sox8	IDA		Mouse	PMID:15590666
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Sox8	IDA		Mouse	PMID:12732652
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Sox8	IDA		Mouse	PMID:15102707
Biological Process	GO:0010817	regulation of hormone levels	Sox8	IMP	MGI:MGI:2154329	Mouse	PMID:19286648
Biological Process	GO:0072034	renal vesicle induction	Sox8	IMP		Mouse	MGI:MGI:4939090|PMID:21212101
Biological Process	GO:0060041	retina development in camera-type eye	Sox8	IGI	MGI:MGI:98371	Mouse	PMID:19490914
Biological Process	GO:0060221	retinal rod cell differentiation	Sox8	IGI	MGI:MGI:98371	Mouse	PMID:19490914
Biological Process	GO:0060009	Sertoli cell development	Sox8	IEP		Mouse	MGI:MGI:5142371|PMID:11875113
Biological Process	GO:0060009	Sertoli cell development	Sox8	IGI	MGI:MGI:98371	Mouse	PMID:19124014
Biological Process	GO:0007165	signal transduction	Sox8	IMP		Mouse	MGI:MGI:4939090|PMID:21212101
Biological Process	GO:0035914	skeletal muscle cell differentiation	Sox8	IMP		Mouse	PMID:22147266
Biological Process	GO:0007283	spermatogenesis	Sox8	IMP	MGI:MGI:3795214	Mouse	PMID:18342849
Biological Process	GO:0007283	spermatogenesis	Sox8	IGI	MGI:MGI:98371	Mouse	PMID:19124014
Biological Process	GO:0072197	ureter morphogenesis	Sox8	IGI	MGI:MGI:98371	Mouse	PMID:21212101

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern