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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Sp1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sp1
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0043425bHLH transcription factor bindingSp1IPIUniProtKB:Q99PV5MouseMGI:MGI:5297791|PMID:12657651
Molecular FunctionGO:0000987cis-regulatory region sequence-specific DNA bindingSp1IDAMousePMID:9705320
Molecular FunctionGO:0000987cis-regulatory region sequence-specific DNA bindingSp1IDAMousePMID:15511642
Molecular FunctionGO:0000987cis-regulatory region sequence-specific DNA bindingSp1IDAMousePMID:19943855
Molecular FunctionGO:0003677DNA bindingSP1IDAHumanPMID:12560508
Molecular FunctionGO:0003677DNA bindingSp1IDAMousePMID:9738004
Molecular FunctionGO:0003677DNA bindingSp1IDAMousePMID:12119294
Molecular FunctionGO:0003677DNA bindingSp1IDAMousePMID:14630713
Molecular FunctionGO:0003677DNA bindingSp1IDAMousePMID:15589828
Molecular FunctionGO:0003677DNA bindingSp1IDAMousePMID:14667815
Molecular FunctionGO:0003677DNA bindingSp1IDAMousePMID:16886906
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificSP1IDAHumanPMID:14701757
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificSP1IDAHumanPMID:16691198
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificSP1IDAHumanPMID:21659522
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificSP1IDAHumanPMID:2833704
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificSp1IDAMousePMID:19943855
Molecular FunctionGO:0003700DNA-binding transcription factor activitySP1IDAHumanPMID:12169688
Molecular FunctionGO:0003700DNA-binding transcription factor activitySP1IDAHumanPMID:12560508
Molecular FunctionGO:0003700DNA-binding transcription factor activitySp1IDAMousePMID:29781215
Molecular FunctionGO:0003700DNA-binding transcription factor activitySp1IMPMousePMID:12119294
Molecular FunctionGO:0003700DNA-binding transcription factor activitySp1IDAMousePMID:15589828
Molecular FunctionGO:0003700DNA-binding transcription factor activitySp1IDAMousePMID:1524678
Molecular FunctionGO:0003700DNA-binding transcription factor activitySp1IDAMousePMID:15282343
Molecular FunctionGO:0003700DNA-binding transcription factor activitysp1IDAZfishPMID:21040790
Molecular FunctionGO:0000981DNA-binding transcription factor activity, RNA polymerase II-specificSp1IDAMousePMID:22331133
Molecular FunctionGO:0003690double-stranded DNA bindingSP1IDAHumanPMID:20371611
Molecular FunctionGO:0003690double-stranded DNA bindingSp1IDAMousePMID:15282343
Molecular FunctionGO:0003690double-stranded DNA bindingSp1IDARatPMID:10837920|RGD:1626488
Molecular FunctionGO:0003690double-stranded DNA bindingsp1IDAZfishPMID:21040790
Molecular FunctionGO:0035035histone acetyltransferase bindingSp1IPIRGD:620036RatPMID:19765194|RGD:2316171
Molecular FunctionGO:0042826histone deacetylase bindingSP1IPIUniProtKB:Q92769HumanPMID:17827154
Molecular FunctionGO:0042826histone deacetylase bindingSP1IPIUniProtKB:P56524HumanPMID:18850004
Molecular FunctionGO:0042826histone deacetylase bindingSP1IPIUniProtKB:Q13547HumanPMID:18850004
Molecular FunctionGO:0042802identical protein bindingSP1IPIUniProtKB:P08047HumanPMID:10393239
Molecular FunctionGO:0042802identical protein bindingSP1IPIUniProtKB:P08047HumanPMID:20211142
Molecular FunctionGO:0060090molecular adaptor activitySP1EXPHumanPMID:22855260
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:P18576HumanPMID:10393239
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:P23708HumanPMID:10393239
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:P62195HumanPMID:10816420
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:P14859HumanPMID:10976766
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:P32519HumanPMID:10976766
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:P51610HumanPMID:10976766
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q12772HumanPMID:10976766
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q13118HumanPMID:10976766
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q15459HumanPMID:10976766
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q7Z3K3HumanPMID:10976766
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q8IXK0HumanPMID:10976766
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:P10636HumanPMID:10987820
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:O95365HumanPMID:12004059
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q6VMQ6HumanPMID:12665582
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:P51610HumanPMID:12670868
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q9UQR1HumanPMID:12771217
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q13547HumanPMID:12847090
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q9NY61HumanPMID:12847090
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:O55170HumanPMID:16582099
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q04886HumanPMID:16582099
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q05066HumanPMID:16582099
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q8N3Y7HumanPMID:16691198
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q16665HumanPMID:17024177
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q99814HumanPMID:17024177
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q9UL17HumanPMID:17075044
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:P01106HumanPMID:17418410
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:P16333HumanPMID:17474147
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q13547HumanPMID:18003922
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q06455HumanPMID:18519037
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:P14859HumanPMID:19070619
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q01664HumanPMID:19505873
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q8TBE0HumanPMID:19666599
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q99801HumanPMID:20716579
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q12772HumanPMID:20936779
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:P40763HumanPMID:21184768
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q13485HumanPMID:21297662
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q92988HumanPMID:21297662
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q8N726HumanPMID:21555589
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:P04637HumanPMID:21831840
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:P40763HumanPMID:24396070
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q8N680HumanPMID:25609694
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q15545HumanPMID:7824954
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:Q01094HumanPMID:8657141
Molecular FunctionGO:0005515protein bindingSP1IPIUniProtKB:P03372HumanPMID:9328340
Molecular FunctionGO:0005515protein bindingSp1IPIUniProtKB:Q96DY5MouseMGI:MGI:6154496|PMID:27918959
Molecular FunctionGO:0005515protein bindingSp1IPIPR:P70354MousePMID:1909605
Molecular FunctionGO:0005515protein bindingSp1IPIPR:P42669MousePMID:15282343
Molecular FunctionGO:0005515protein bindingSp1IPIPR:O35295MousePMID:15282343
Molecular FunctionGO:0005515protein bindingSp1IPIUniProtKB:P18576RatPMID:10393239|RGD:8553812
Molecular FunctionGO:0005515protein bindingSp1IPIUniProtKB:Q8K1P7RatPMID:19081374|RGD:8554007
Molecular FunctionGO:0042803protein homodimerization activitySP1IDAHumanPMID:10393239
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSP1IDAHumanPMID:14701757
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSP1IDAHumanPMID:16691198
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSP1IDAHumanPMID:21659522
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSp1IDAMouseMGI:MGI:5297791|PMID:12657651
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSp1IDAMouseMGI:MGI:5574437|PMID:24030830
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSp1IDAMouseMGI:MGI:5487528|PMID:21029371
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSp1IDAMousePMID:17670746
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSp1IDAMousePMID:18434628
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSp1IDAMousePMID:8617793
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSp1IDAMousePMID:15094381
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSp1IDAMousePMID:22331133
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSp1IDAMousePMID:11004506
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSp1IGIUniProtKB:P01139RatPMID:10362258|RGD:13506263
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSp1IDARatPMID:26908121|RGD:11059577
Molecular FunctionGO:0000977RNA polymerase II transcription regulatory region sequence-specific DNA bindingSP1IDAHumanPMID:14979875
Molecular FunctionGO:0000977RNA polymerase II transcription regulatory region sequence-specific DNA bindingSp1IMPRatPMID:14979875|RGD:10047233
Molecular FunctionGO:0061629RNA polymerase II-specific DNA-binding transcription factor bindingSp1IPIUniProtKB:Q99PV5MouseMGI:MGI:5297791|PMID:12657651
Molecular FunctionGO:0043565sequence-specific DNA bindingSP1IDAHumanPMID:12169688
Molecular FunctionGO:0043565sequence-specific DNA bindingSp1IDAMousePMID:11071760
Molecular FunctionGO:0043565sequence-specific DNA bindingSp1IDARatPMID:10837920|RGD:1626488
Molecular FunctionGO:0043565sequence-specific DNA bindingSp1IDARatPMID:12753154|RGD:1599299
Molecular FunctionGO:1990837sequence-specific double-stranded DNA bindingSP1IDAHumanPMID:28473536
Molecular FunctionGO:0000976transcription cis-regulatory region bindingSP1IDAHumanPMID:18293083
Molecular FunctionGO:0000976transcription cis-regulatory region bindingSP1IDAHumanPMID:18850004
Molecular FunctionGO:0001221transcription coregulator bindingSP1IPIUniProtKB:Q92908HumanPMID:14988427
Molecular FunctionGO:0001221transcription coregulator bindingSp1IPIUniProtKB:A0A0G2QC09RatPMID:10362258|RGD:13506263
Cellular ComponentGO:0000785chromatinSP1IDAHumanPMID:15831516
Cellular ComponentGO:0000785chromatinSP1IDAHumanPMID:21659522
Cellular ComponentGO:0000785chromatinSP1IDAHumanPMID:27030318
Cellular ComponentGO:0000785chromatinSP1IDAHumanPMID:19307576
Cellular ComponentGO:0000785chromatinSp1IDAMouseMGI:MGI:5487528|PMID:21029371
Cellular ComponentGO:0000785chromatinSp1IDARatPMID:26908121|RGD:11059577
Cellular ComponentGO:0000791euchromatinSP1IDAHumanPMID:14701757
Cellular ComponentGO:0005654nucleoplasmSP1IDAHumanGO_REF:0000052
Cellular ComponentGO:0005654nucleoplasmSP1IDAHumanPMID:12498690
Cellular ComponentGO:0005634nucleusSP1IDAHumanPMID:12169688
Cellular ComponentGO:0005634nucleusSp1IDAMouseMGI:MGI:6154496|PMID:27918959
Cellular ComponentGO:0005634nucleusSp1IDAMousePMID:12119294
Cellular ComponentGO:0005634nucleusSp1IDAMousePMID:11004506
Cellular ComponentGO:0005634nucleusSp1IDAMousePMID:15817708
Cellular ComponentGO:0005634nucleusSp1IDAMousePMID:16141233
Cellular ComponentGO:0005634nucleusSp1IDAMousePMID:15282343
Cellular ComponentGO:0005634nucleusSp1IDAMousePMID:9705320
Cellular ComponentGO:0005634nucleusSp1IDAMousePMID:15016652
Cellular ComponentGO:0005634nucleusSp1IDARatPMID:10837920|RGD:1626488
Cellular ComponentGO:0005634nucleusSp1IDARatPMID:12753154|RGD:1599299
Cellular ComponentGO:0005634nucleusSp1IDARatPMID:14979875|RGD:10047233
Cellular ComponentGO:0032993protein-DNA complexSp1IDARatPMID:19765194|RGD:2316171
Cellular ComponentGO:0032993protein-DNA complexSp1IPIUniProtKB:A0A0G2K5M1,UniProtKB:A0A0G2QC09RatPMID:10362258|RGD:13506263
Cellular ComponentGO:0017053transcription repressor complexSP1IDAHumanPMID:16691198
Biological ProcessGO:0071391cellular response to estrogen stimulusSp1IEPRatPMID:17272396|RGD:152177689
Biological ProcessGO:0032869cellular response to insulin stimulusSp1IDARatPMID:26908121|RGD:11059577
Biological ProcessGO:1904568cellular response to wortmanninSp1IEPRatPMID:17272396|RGD:152177689
Biological ProcessGO:0034224cellular response to zinc ion starvationSp1IEPRatPMID:21893222|RGD:151667428
Biological ProcessGO:0060216definitive hemopoiesisSp1IGIMGI:MGI:1277166MousePMID:17584888
Biological ProcessGO:0006351DNA-templated transcriptionsp1IDAZfishPMID:21040790|ZFIN:ZDB-PUB-101108-15
Biological ProcessGO:0048596embryonic camera-type eye morphogenesisSp1IGIMGI:MGI:1277166MousePMID:17584888
Biological ProcessGO:0001892embryonic placenta developmentSp1IGIMGI:MGI:1277166MousePMID:17584888
Biological ProcessGO:0060136embryonic process involved in female pregnancySp1IGIMGI:MGI:1277166MousePMID:17584888
Biological ProcessGO:0048706embryonic skeletal system developmentSp1IGIMGI:MGI:1277166MousePMID:17584888
Biological ProcessGO:0043353enucleate erythrocyte differentiationSp1IGIMGI:MGI:1277166MousePMID:17584888
Biological ProcessGO:0001701in utero embryonic developmentSp1IGIMGI:MGI:1277166MousePMID:17584888
Biological ProcessGO:0001889liver developmentSp1IGIMGI:MGI:1277166MousePMID:17584888
Biological ProcessGO:0030324lung developmentSp1IGIMGI:MGI:1277166MousePMID:17584888
Biological ProcessGO:0030219megakaryocyte differentiationSp1IGIMGI:MGI:1277166MousePMID:17584888
Biological ProcessGO:0042789mRNA transcription by RNA polymerase IISp1IDAMousePMID:22331133
Biological ProcessGO:0002318myeloid progenitor cell differentiationSp1IGIMGI:MGI:1277166MousePMID:17584888
Biological ProcessGO:0001503ossificationSp1IGIMGI:MGI:1277166MousePMID:17584888
Biological ProcessGO:0043923positive regulation by host of viral transcriptionSP1IDAHumanPMID:2833704
Biological ProcessGO:1902004positive regulation of amyloid-beta formationSP1IMPHumanPMID:14701757
Biological ProcessGO:0045766positive regulation of angiogenesisSP1IMPHumanPMID:23802567
Biological ProcessGO:0043536positive regulation of blood vessel endothelial cell migrationSP1IMPHumanPMID:23802567
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionSP1IDAHumanPMID:14580349
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionSP1IDAHumanPMID:12771217
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionSp1IDAMouseMGI:MGI:5574437|PMID:24030830
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionSp1IDAMousePMID:15282343
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionSp1IDAMousePMID:15589828
Biological ProcessGO:0010628positive regulation of gene expressionSP1IMPHumanPMID:23802567
Biological ProcessGO:0010628positive regulation of gene expressionSP1IMPHumanPMID:24244514
Biological ProcessGO:1904828positive regulation of hydrogen sulfide biosynthetic processSP1IDAHumanPMID:21659522
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISP1IDAHumanPMID:12169688
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISP1IMPHumanPMID:14701757
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISP1IGIUniProtKB:O95644HumanPMID:14979875
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISP1IGIUniProtKB:P18146HumanPMID:14979875
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISP1IGIUniProtKB:Q02447HumanPMID:14979875
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISP1IMPHumanPMID:14979875
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISP1IDAHumanPMID:16691198
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISP1IDAHumanPMID:19263243
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISP1IGIUniProtKB:Q04206HumanPMID:21518763
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISP1IDAHumanPMID:21659522
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISP1IDAHumanPMID:27030318
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISP1IDAHumanPMID:2833704
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISp1IDAMouseMGI:MGI:6393173|PMID:14701757
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISp1IMPMouseMGI:MGI:5487528|PMID:21029371
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISp1IGIMGI:MGI:106587MousePMID:15663180
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISp1IDAMousePMID:1524678
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISp1IMPRatPMID:26908121|RGD:11059577
Biological ProcessGO:1905564positive regulation of vascular endothelial cell proliferationSP1IMPHumanPMID:23802567
Biological ProcessGO:0006355regulation of DNA-templated transcriptionSP1IDAHumanPMID:12560508
Biological ProcessGO:0006355regulation of DNA-templated transcriptionSp1IMPMouseMGI:MGI:6154496|PMID:27918959
Biological ProcessGO:0006355regulation of DNA-templated transcriptionSp1IMPMousePMID:12119294
Biological ProcessGO:0006355regulation of DNA-templated transcriptionsp1IDAZfishPMID:21040790|ZFIN:ZDB-PUB-101108-15
Biological ProcessGO:0006357regulation of transcription by RNA polymerase IISp1IMPRatPMID:11457835|RGD:737656
Biological ProcessGO:0033194response to hydroperoxideSp1IDAMouseMGI:MGI:6154496|PMID:27918959
Biological ProcessGO:0001829trophectodermal cell differentiationSp1IGIMGI:MGI:1277166MousePMID:17584888

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory