Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SP3
  • Mouse genes Sp3
  • Rat genes Sp3
  • Zfish genes sp3a,sp3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sp3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Sp3	IDA		Mouse	PMID:15522233
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	Sp3	IDA		Mouse	PMID:19943855
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	Sp3	IDA		Mouse	PMID:15511642
Molecular Function	GO:0003677	DNA binding	Sp3	IDA		Mouse	PMID:14630713
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Sp3	IDA		Mouse	MGI:MGI:5009400|PMID:17130167
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Sp3	IDA		Rat	PMID:17130167|RGD:8553999
Molecular Function	GO:0003690	double-stranded DNA binding	Sp3	IDA		Mouse	PMID:15282343
Molecular Function	GO:0005515	protein binding	SP3	IPI	UniProtKB:Q14527	Human	PMID:10391891
Molecular Function	GO:0005515	protein binding	SP3	IPI	UniProtKB:P03372	Human	PMID:10816575
Molecular Function	GO:0005515	protein binding	SP3	IPI	UniProtKB:Q13547	Human	PMID:12176973
Molecular Function	GO:0005515	protein binding	SP3	IPI	UniProtKB:Q92769	Human	PMID:12176973
Molecular Function	GO:0005515	protein binding	SP3	IPI	UniProtKB:P42858	Human	PMID:17500595
Molecular Function	GO:0005515	protein binding	SP3	IPI	UniProtKB:P03372	Human	PMID:31527615
Molecular Function	GO:0005515	protein binding	SP3	IPI	UniProtKB:P14678-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SP3	IPI	UniProtKB:Q5MJ10	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SP3	IPI	UniProtKB:Q6MZP7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SP3	IPI	UniProtKB:Q7Z3K3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SP3	IPI	UniProtKB:Q96BD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SP3	IPI	UniProtKB:Q96Q77	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SP3	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Sp3	IPI	UniProtKB:Q9Z2D6	Mouse	MGI:MGI:6716954|PMID:20385708
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Sp3	IDA		Mouse	PMID:17670746
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Sp3	IDA		Mouse	PMID:15094381
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Sp3	IGI	UniProtKB:P01139	Rat	PMID:10362258|RGD:13506263
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SP3	IDA		Human	PMID:14979875
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Sp3	IMP		Rat	PMID:14979875|RGD:10047233
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	SP3	IPI	UniProtKB:Q13127	Human	PMID:17130167
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Sp3	IPI	UniProtKB:Q8VIG1	Mouse	MGI:MGI:5009400|PMID:17130167
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Sp3	IPI	UniProtKB:O54963	Rat	PMID:17130167|RGD:8553999
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	SP3	IDA		Human	PMID:28473536
Cellular Component	GO:0005829	cytosol	SP3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SP3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Sp3	IDA		Mouse	PMID:15282343
Cellular Component	GO:0005634	nucleus	Sp3	IDA		Mouse	PMID:15817708
Cellular Component	GO:0005634	nucleus	Sp3	IDA		Rat	PMID:14979875|RGD:10047233
Cellular Component	GO:0032993	protein-DNA complex	Sp3	IPI	UniProtKB:A0A0G2QC09,UniProtKB:Q01714	Rat	PMID:10362258|RGD:13506263
Cellular Component	GO:0017053	transcription repressor complex	Sp3	IDA		Mouse	MGI:MGI:5009400|PMID:17130167
Cellular Component	GO:0017053	transcription repressor complex	Sp3	IDA		Rat	PMID:17130167|RGD:8553999
Biological Process	GO:0030183	B cell differentiation	Sp3	IMP	MGI:MGI:2182438	Mouse	PMID:12676787
Biological Process	GO:0060216	definitive hemopoiesis	Sp3	IGI	MGI:MGI:98372	Mouse	PMID:17584888
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	Sp3	IGI	MGI:MGI:98372	Mouse	PMID:17584888
Biological Process	GO:0001892	embryonic placenta development	Sp3	IGI	MGI:MGI:98372	Mouse	PMID:17584888
Biological Process	GO:0060136	embryonic process involved in female pregnancy	Sp3	IGI	MGI:MGI:98372	Mouse	PMID:17584888
Biological Process	GO:0048706	embryonic skeletal system development	Sp3	IGI	MGI:MGI:98372	Mouse	PMID:17584888
Biological Process	GO:0043353	enucleate erythrocyte differentiation	Sp3	IGI	MGI:MGI:98372	Mouse	PMID:17584888
Biological Process	GO:0030218	erythrocyte differentiation	Sp3	IMP	MGI:MGI:2182438	Mouse	PMID:12676787
Biological Process	GO:0030851	granulocyte differentiation	Sp3	IMP	MGI:MGI:2182438	Mouse	PMID:12676787
Biological Process	GO:0001701	in utero embryonic development	Sp3	IGI	MGI:MGI:98372	Mouse	PMID:17584888
Biological Process	GO:0001889	liver development	Sp3	IGI	MGI:MGI:98372	Mouse	PMID:17584888
Biological Process	GO:0030324	lung development	Sp3	IGI	MGI:MGI:98372	Mouse	PMID:17584888
Biological Process	GO:0030219	megakaryocyte differentiation	Sp3	IGI	MGI:MGI:98372	Mouse	PMID:17584888
Biological Process	GO:0030224	monocyte differentiation	Sp3	IMP	MGI:MGI:2182438	Mouse	PMID:12676787
Biological Process	GO:0002318	myeloid progenitor cell differentiation	Sp3	IGI	MGI:MGI:98372	Mouse	PMID:17584888
Biological Process	GO:0001779	natural killer cell differentiation	Sp3	IMP	MGI:MGI:2182438	Mouse	PMID:12676787
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	SP3	IMP		Human	PMID:20091743
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Sp3	IDA		Mouse	MGI:MGI:5009400|PMID:17130167
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Sp3	IDA		Rat	PMID:17130167|RGD:8553999
Biological Process	GO:0001503	ossification	Sp3	IGI	MGI:MGI:98372	Mouse	PMID:17584888
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	SP3	IDA		Human	PMID:12771217
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SP3	IGI	UniProtKB:P08047	Human	PMID:14979875
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SP3	IMP		Human	PMID:14979875
Biological Process	GO:0006355	regulation of DNA-templated transcription	SP3	IDA		Human	PMID:12560508
Biological Process	GO:0030217	T cell differentiation	Sp3	IMP	MGI:MGI:2182438	Mouse	PMID:12676787
Biological Process	GO:0001829	trophectodermal cell differentiation	Sp3	IGI	MGI:MGI:98372	Mouse	PMID:17584888

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern