Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SP7
  • Mouse genes Sp7
  • Rat genes Sp7
  • Zfish genes sp7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sp7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0017151	DEAD/H-box RNA helicase binding	Sp7	IPI	UniProtKB:Q08211	Mouse	MGI:MGI:5306298|PMID:17303075
Molecular Function	GO:0003677	DNA binding	Sp7	IDA		Mouse	PMID:11792318
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Sp7	IDA		Mouse	MGI:MGI:3589047|PMID:16041384
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Sp7	IDA		Mouse	PMID:30026585
Molecular Function	GO:1990841	promoter-specific chromatin binding	sp7	IMP		Zfish	PMID:31894108
Molecular Function	GO:0005515	protein binding	SP7	IPI	UniProtKB:O95995	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SP7	IPI	UniProtKB:P47897	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SP7	IPI	UniProtKB:Q9BVG3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SP7	IPI	UniProtKB:Q9H5Z6-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Sp7	IPI	UniProtKB:Q9JJF3	Mouse	MGI:MGI:4418587|PMID:19927124
Molecular Function	GO:0005515	protein binding	Sp7	IPI	UniProtKB:Q9H6W3|UniProtKB:Q9JJF3	Mouse	MGI:MGI:4418587|PMID:19927124
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Sp7	IDA		Mouse	MGI:MGI:3589047|PMID:16041384
Cellular Component	GO:0005737	cytoplasm	SP7	IDA		Human	PMID:18471237
Cellular Component	GO:0005737	cytoplasm	Sp7	IDA		Mouse	PMID:22886301
Cellular Component	GO:0005634	nucleus	SP7	IDA		Human	PMID:18471237
Cellular Component	GO:0005634	nucleus	Sp7	IDA		Mouse	PMID:11792318
Biological Process	GO:0034224	cellular response to zinc ion starvation	Sp7	IEP		Rat	PMID:21893222|RGD:151667428
Biological Process	GO:0071529	cementum mineralization	Sp7	IGI	MGI:MGI:1915401	Mouse	PMID:31059863
Biological Process	GO:0071529	cementum mineralization	Sp7	IMP	MGI:MGI:3608932	Mouse	PMID:31059863
Biological Process	GO:0071529	cementum mineralization	Sp7	IMP		Mouse	PMID:31059863
Biological Process	GO:0071529	cementum mineralization	Sp7	IGI	MGI:MGI:97370	Mouse	PMID:31059863
Biological Process	GO:0071529	cementum mineralization	Sp7	IDA		Mouse	PMID:31059863
Biological Process	GO:0071529	cementum mineralization	Sp7	IMP	MGI:MGI:3785162	Mouse	PMID:31059863
Biological Process	GO:0060363	cranial suture morphogenesis	sp7	IMP	ZFIN:ZDB-GENO-170620-3	Zfish	PMID:26992365
Biological Process	GO:0097187	dentinogenesis	sp7	IMP	ZFIN:ZDB-GENO-181119-1	Zfish	PMID:29409769
Biological Process	GO:0071344	diphosphate metabolic process	Sp7	IMP	MGI:MGI:3608932	Mouse	PMID:31059863
Biological Process	GO:0010467	gene expression	Sp7	IMP		Mouse	PMID:31059863
Biological Process	GO:0010467	gene expression	Sp7	IMP	MGI:MGI:3608932	Mouse	PMID:31059863
Biological Process	GO:0010467	gene expression	Sp7	IDA		Mouse	PMID:31059863
Biological Process	GO:0060218	hematopoietic stem cell differentiation	SP7	IDA		Human	PMID:18932205
Biological Process	GO:0001649	osteoblast differentiation	SP7	IDA		Human	PMID:18932205
Biological Process	GO:0001649	osteoblast differentiation	Sp7	IMP	MGI:MGI:2159411	Mouse	PMID:11792318
Biological Process	GO:0001649	osteoblast differentiation	sp7	IMP	ZFIN:ZDB-GENO-170620-3	Zfish	PMID:26992365
Biological Process	GO:0010628	positive regulation of gene expression	sp7	IMP		Zfish	PMID:31894108
Biological Process	GO:2000738	positive regulation of stem cell differentiation	SP7	IDA		Human	PMID:18932205
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SP7	IDA		Human	PMID:18932205
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Sp7	IDA		Mouse	MGI:MGI:3589047|PMID:16041384
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Sp7	IDA		Mouse	MGI:MGI:6209006|PMID:30026585
Biological Process	GO:0051336	regulation of hydrolase activity	Sp7	IMP	MGI:MGI:3608932	Mouse	PMID:31059863
Biological Process	GO:0033688	regulation of osteoblast proliferation	sp7	IMP	ZFIN:ZDB-GENO-170620-3	Zfish	PMID:26992365
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Sp7	IDA		Mouse	PMID:11792318
Biological Process	GO:0032868	response to insulin	Sp7	IEP		Rat	PMID:20818503|RGD:151667419
Biological Process	GO:0014070	response to organic cyclic compound	Sp7	IEP		Rat	PMID:20818503|RGD:151667419

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern