Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPAG5
  • Mouse genes Spag5
  • Rat genes Spag5
  • Zfish genes si:dkey-25o16.4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spag5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008017	microtubule binding	SPAG5	IDA		Human	PMID:27462074
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:O14965	Human	PMID:18361916
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q9H816	Human	PMID:19197158
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q7Z460	Human	PMID:20852589
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q9Y448	Human	PMID:21402792
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:P63167	Human	PMID:22965910
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q8N122	Human	PMID:23953116
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q9BZF1	Human	PMID:24424245
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:A0AVN2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:G3V1X1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:O43602	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:O60573	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:P62875	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q08AF8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q0D2H9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q53FD0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q5SQN1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q5W5X9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q63HK5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q7Z3B3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q86Y33	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q8TCE9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q8TD31-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q969G3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q96CS2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q96FE5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q96IZ5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q96NC0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q9H788	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q9NVF7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q9NX04	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q9NX63	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q9Y2J4-4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q9Y5N6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q15154	Human	PMID:26297806
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q96SN8	Human	PMID:26297806
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q9P209	Human	PMID:26297806
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:A0A0S2Z5X4	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q9BSJ6	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q14980	Human	PMID:27462074
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q9Y5N6	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:O00444	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:O76041	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:O95678	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:P12035	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:P55040	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q16512	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q7Z3I7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q86VF2-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q8TCE9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q8TD31-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q96HA1-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPAG5	IPI	UniProtKB:Q9H3R5	Human	PMID:32296183
Cellular Component	GO:0034451	centriolar satellite	SPAG5	IMP		Human	PMID:26297806
Cellular Component	GO:0036064	ciliary basal body	Spag5	IDA		Mouse	PMID:23351521
Cellular Component	GO:0035253	ciliary rootlet	Spag5	IDA		Mouse	PMID:23351521
Cellular Component	GO:0005737	cytoplasm	SPAG5	IDA		Human	PMID:27462074
Cellular Component	GO:0005829	cytosol	SPAG5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000776	kinetochore	SPAG5	IDA		Human	PMID:21402792
Cellular Component	GO:0000776	kinetochore	SPAG5	IDA		Human	PMID:27462074
Cellular Component	GO:0035371	microtubule plus-end	SPAG5	IDA		Human	PMID:21402792
Cellular Component	GO:0072686	mitotic spindle	SPAG5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0072686	mitotic spindle	SPAG5	IDA		Human	PMID:21402792
Cellular Component	GO:0072686	mitotic spindle	SPAG5	IDA		Human	PMID:27462074
Cellular Component	GO:0072686	mitotic spindle	Spag5	IDA		Mouse	PMID:12893248
Cellular Component	GO:0097431	mitotic spindle pole	SPAG5	IDA		Human	PMID:27462074
Cellular Component	GO:0016604	nuclear body	SPAG5	IDA		Human	GO_REF:0000052
Biological Process	GO:0007059	chromosome segregation	SPAG5	IMP		Human	PMID:21402792
Biological Process	GO:0051294	establishment of spindle orientation	Spag5	IMP		Mouse	PMID:22031545
Biological Process	GO:0000070	mitotic sister chromatid segregation	SPAG5	IMP		Human	PMID:21402792
Biological Process	GO:0032388	positive regulation of intracellular transport	SPAG5	IMP		Human	PMID:27462074
Biological Process	GO:1905832	positive regulation of spindle assembly	SPAG5	IMP		Human	PMID:27462074
Biological Process	GO:0071539	protein localization to centrosome	SPAG5	IMP		Human	PMID:26297806
Biological Process	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	SPAG5	IMP		Human	PMID:21402792
Biological Process	GO:0090235	regulation of metaphase plate congression	SPAG5	IMP		Human	PMID:27462074
Biological Process	GO:0007051	spindle organization	SPAG5	IMP		Human	PMID:21402792

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern