Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Sparc

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SPARC
- Mouse genes Sparc
- Rat genes Sparc
- Zfish genes sparc
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sparc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	SPARC	IDA		Human	PMID:7034958
Molecular Function	GO:0005509	calcium ion binding	Sparc	IDA		Mouse	MGI:MGI:5887197\|PMID:3427055
Molecular Function	GO:0005509	calcium ion binding	Sparc	IDA		Rat	PMID:2322281\|RGD:2300028
Molecular Function	GO:0005518	collagen binding	SPARC	IDA		Human	PMID:7034958
Molecular Function	GO:0005518	collagen binding	SPARC	IDA		Human	PMID:9501084
Molecular Function	GO:0050840	extracellular matrix binding	Sparc	IDA		Mouse	PMID:18757743
Molecular Function	GO:0043167	ion binding	Sparc	EXP		Mouse	MGI:MGI:5887197\|PMID:3427055
Molecular Function	GO:0005515	protein binding	SPARC	IPI	UniProtKB:Q2TV77	Human	PMID:18808384
Molecular Function	GO:0005515	protein binding	SPARC	IPI	UniProtKB:P02461-1	Human	PMID:19011090
Molecular Function	GO:0005515	protein binding	SPARC	IPI	UniProtKB:Q99972	Human	PMID:20926826
Molecular Function	GO:0005515	protein binding	SPARC	IPI	UniProtKB:P07996	Human	PMID:3402455
Molecular Function	GO:0005515	protein binding	Sparc	IPI	PR:Q6EAL8	Mouse	PMID:21182835
Molecular Function	GO:0044183	protein folding chaperone	Sparc	EXP		Mouse	MGI:MGI:5887197\|PMID:3427055
Cellular Component	GO:0009986	cell surface	SPARC	IDA		Human	PMID:15389586
Cellular Component	GO:0009986	cell surface	SPARC	IDA		Human	PMID:3400777
Cellular Component	GO:0062023	collagen-containing extracellular matrix	SPARC	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Sparc	HDA		Mouse	MGI:MGI:6201853\|PMID:28071719
Cellular Component	GO:0005737	cytoplasm	SPARC	IDA		Human	PMID:11856645
Cellular Component	GO:0005737	cytoplasm	SPARC	IDA		Human	PMID:15389586
Cellular Component	GO:0005737	cytoplasm	SPARC	IDA		Human	PMID:3400777
Cellular Component	GO:0005737	cytoplasm	Sparc	IDA		Rat	PMID:9705970\|RGD:2300065
Cellular Component	GO:0031012	extracellular matrix	Sparc	IDA		Mouse	PMID:8906420
Cellular Component	GO:0005576	extracellular region	SPARC	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	Sparc	HDA		Mouse	MGI:MGI:5640941\|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Sparc	IDA		Mouse	MGI:MGI:5887197\|PMID:3427055
Cellular Component	GO:0005615	extracellular space	Sparc	IDA		Rat	PMID:18758911\|RGD:2301841
Cellular Component	GO:0005615	extracellular space	Sparc	IDA		Rat	PMID:2322281\|RGD:2300028
Cellular Component	GO:0098978	glutamatergic synapse	Sparc	EXP		Rat	PMID:21788491\|RGD:13702385
Cellular Component	GO:0098978	glutamatergic synapse	Sparc	IDA		Rat	PMID:21788491\|RGD:13702385
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	SPARC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016363	nuclear matrix	SPARC	IDA		Human	PMID:15389586
Cellular Component	GO:0005634	nucleus	Sparc	IDA		Rat	PMID:9705970\|RGD:2300065
Cellular Component	GO:0031091	platelet alpha granule	SPARC	IDA		Human	PMID:1737102
Cellular Component	GO:0031092	platelet alpha granule membrane	SPARC	IDA		Human	PMID:1737102
Cellular Component	GO:0045202	synapse	Sparc	EXP		Rat	PMID:16507876\|RGD:13702274
Cellular Component	GO:0045202	synapse	Sparc	IDA		Rat	PMID:16507876\|RGD:13702274
Cellular Component	GO:0031982	vesicle	Sparc	IDA		Rat	PMID:18758911\|RGD:2301841
Biological Process	GO:0060348	bone development	Sparc	IMP		Mouse	PMID:22876197
Biological Process	GO:0051216	cartilage development	sparc	IMP	ZFIN:ZDB-MRPHLNO-081105-1	Zfish	PMID:18430553
Biological Process	GO:0051216	cartilage development	sparc	IMP	ZFIN:ZDB-MRPHLNO-081105-2	Zfish	PMID:18430553
Biological Process	GO:0071363	cellular response to growth factor stimulus	Sparc	IDA		Mouse	PMID:7848824
Biological Process	GO:0030218	erythrocyte differentiation	sparc	IGI	ZFIN:ZDB-GENE-060623-2	Zfish	PMID:23183322
Biological Process	GO:0030218	erythrocyte differentiation	sparc	IMP	ZFIN:ZDB-MRPHLNO-081105-2	Zfish	PMID:23183322
Biological Process	GO:0007507	heart development	Sparc	IEP		Rat	PMID:8287436\|RGD:2300077
Biological Process	GO:0048839	inner ear development	Sparc	IEP		Rat	PMID:11335086\|RGD:2300061
Biological Process	GO:0030324	lung development	Sparc	IMP		Rat	PMID:7654384\|RGD:2300073
Biological Process	GO:0016525	negative regulation of angiogenesis	SPARC	IDA		Human	PMID:12867428
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	SPARC	IDA		Human	PMID:12867428
Biological Process	GO:0001503	ossification	Sparc	IEP		Rat	PMID:12365801\|RGD:2300057
Biological Process	GO:0030916	otic vesicle formation	sparc	IMP	ZFIN:ZDB-MRPHLNO-081105-2	Zfish	PMID:18430553
Biological Process	GO:0030916	otic vesicle formation	sparc	IMP	ZFIN:ZDB-MRPHLNO-081105-1	Zfish	PMID:18430553
Biological Process	GO:0032474	otolith morphogenesis	sparc	IMP	ZFIN:ZDB-MRPHLNO-090409-1	Zfish	PMID:18784957
Biological Process	GO:0032474	otolith morphogenesis	sparc	IMP	ZFIN:ZDB-MRPHLNO-060601-6	Zfish	PMID:18784957
Biological Process	GO:0060037	pharyngeal system development	sparc	IMP	ZFIN:ZDB-MRPHLNO-081105-2	Zfish	PMID:18430553
Biological Process	GO:0060037	pharyngeal system development	sparc	IMP	ZFIN:ZDB-MRPHLNO-081105-1	Zfish	PMID:18430553
Biological Process	GO:0043473	pigmentation	Sparc	IMP	MGI:MGI:4432869	Mouse	PMID:25340873
Biological Process	GO:0010595	positive regulation of endothelial cell migration	SPARC	IDA		Human	PMID:12867428
Biological Process	GO:0022604	regulation of cell morphogenesis	SPARC	IDA		Human	PMID:15389586
Biological Process	GO:0042127	regulation of cell population proliferation	Sparc	IGI	MGI:MGI:88039	Mouse	PMID:17299058
Biological Process	GO:0050807	regulation of synapse organization	Sparc	EXP		Rat	PMID:21788491\|RGD:13702385
Biological Process	GO:0050807	regulation of synapse organization	Sparc	IDA		Rat	PMID:21788491\|RGD:13702385
Biological Process	GO:0046686	response to cadmium ion	Sparc	IEP		Rat	PMID:9232954\|RGD:2300068
Biological Process	GO:0051592	response to calcium ion	Sparc	IEP		Rat	PMID:11897705\|RGD:2300059
Biological Process	GO:0051591	response to cAMP	Sparc	IEP		Rat	PMID:10703670\|RGD:2300026
Biological Process	GO:0034097	response to cytokine	Sparc	IEP		Rat	PMID:10703670\|RGD:2300026
Biological Process	GO:0045471	response to ethanol	Sparc	IEP		Rat	PMID:11371715\|RGD:2300060
Biological Process	GO:0051384	response to glucocorticoid	Sparc	IEP		Rat	PMID:9232954\|RGD:2300068
Biological Process	GO:0009629	response to gravity	Sparc	IEP		Rat	PMID:17384275\|RGD:2300053
Biological Process	GO:0033591	response to L-ascorbic acid	Sparc	IEP		Rat	PMID:9495521\|RGD:2300067
Biological Process	GO:0010288	response to lead ion	Sparc	IEP		Rat	PMID:1412468\|RGD:2300078
Biological Process	GO:0032496	response to lipopolysaccharide	Sparc	IEP		Rat	PMID:10703670\|RGD:2300026
Biological Process	GO:0043434	response to peptide hormone	Sparc	IEP		Rat	PMID:15779007\|RGD:2300055
Biological Process	GO:0048752	semicircular canal morphogenesis	sparc	IMP	ZFIN:ZDB-MRPHLNO-081105-2	Zfish	PMID:18430553
Biological Process	GO:0048752	semicircular canal morphogenesis	sparc	IMP	ZFIN:ZDB-MRPHLNO-081105-1	Zfish	PMID:18430553
Biological Process	GO:0042060	wound healing	Sparc	IEP		Rat	PMID:8245406\|RGD:2300076

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.