Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPAST
  • Mouse genes Spast
  • Rat genes Spast
  • Zfish genes spast
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spast

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043014	alpha-tubulin binding	SPAST	IPI	UniProtKB:P05213	Human	PMID:17389232
Molecular Function	GO:0048487	beta-tubulin binding	SPAST	IPI	UniProtKB:Q9ERD7	Human	PMID:17389232
Molecular Function	GO:0048487	beta-tubulin binding	SPAST	IDA		Human	PMID:26875866
Molecular Function	GO:0008017	microtubule binding	SPAST	IDA		Human	PMID:15716377
Molecular Function	GO:0008017	microtubule binding	SPAST	IDA		Human	PMID:16219033
Molecular Function	GO:0008017	microtubule binding	SPAST	IDA		Human	PMID:17389232
Molecular Function	GO:0008017	microtubule binding	SPAST	IDA		Human	PMID:23745751
Molecular Function	GO:0008017	microtubule binding	SPAST	IDA		Human	PMID:34970964
Molecular Function	GO:0008568	microtubule severing ATPase activity	SPAST	IDA		Human	PMID:15716377
Molecular Function	GO:0008568	microtubule severing ATPase activity	SPAST	IDA		Human	PMID:16219033
Molecular Function	GO:0008568	microtubule severing ATPase activity	SPAST	IDA		Human	PMID:17389232
Molecular Function	GO:0008568	microtubule severing ATPase activity	SPAST	IDA		Human	PMID:23745751
Molecular Function	GO:0008568	microtubule severing ATPase activity	SPAST	IDA		Human	PMID:26875866
Molecular Function	GO:0005515	protein binding	SPAST	IPI	UniProtKB:Q8WXF7	Human	PMID:16815977
Molecular Function	GO:0005515	protein binding	SPAST	IPI	UniProtKB:Q8WXF7-1	Human	PMID:16815977
Molecular Function	GO:0005515	protein binding	SPAST	IPI	UniProtKB:P68363	Human	PMID:17389232
Molecular Function	GO:0005515	protein binding	SPAST	IPI	UniProtKB:Q7LBR1	Human	PMID:18997780
Molecular Function	GO:0005515	protein binding	SPAST	IPI	UniProtKB:Q9H902	Human	PMID:20200447
Molecular Function	GO:0005515	protein binding	SPAST	IPI	UniProtKB:P53990	Human	PMID:20719964
Molecular Function	GO:0005515	protein binding	SPAST	IPI	UniProtKB:Q5T4F4	Human	PMID:23969831
Molecular Function	GO:0005515	protein binding	SPAST	IPI	UniProtKB:O43805	Human	PMID:25390646
Molecular Function	GO:0005515	protein binding	SPAST	IPI	UniProtKB:P53990	Human	PMID:26040712
Cellular Component	GO:0030424	axon	SPAST	IDA		Human	PMID:15269182
Cellular Component	GO:0005813	centrosome	SPAST	IDA		Human	PMID:25390646
Cellular Component	GO:0005737	cytoplasm	SPAST	IDA		Human	PMID:16026783
Cellular Component	GO:0005737	cytoplasm	SPAST	IDA		Human	PMID:19000169
Cellular Component	GO:0005737	cytoplasm	SPAST	IDA		Human	PMID:21545838
Cellular Component	GO:0031410	cytoplasmic vesicle	SPAST	IDA		Human	PMID:21545838
Cellular Component	GO:0005829	cytosol	SPAST	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	SPAST	IDA		Human	PMID:19000169
Cellular Component	GO:0005768	endosome	SPAST	IDA		Human	PMID:19000169
Cellular Component	GO:0070062	extracellular exosome	SPAST	HDA		Human	PMID:19056867
Cellular Component	GO:0015630	microtubule cytoskeleton	SPAST	IDA		Human	PMID:15716377
Cellular Component	GO:0015630	microtubule cytoskeleton	SPAST	IDA		Human	PMID:17389232
Cellular Component	GO:0015630	microtubule cytoskeleton	SPAST	IDA		Human	PMID:19000169
Cellular Component	GO:0015630	microtubule cytoskeleton	Spast	IDA		Mouse	PMID:20530212
Cellular Component	GO:0030496	midbody	SPAST	IDA		Human	PMID:19000169
Cellular Component	GO:0030496	midbody	SPAST	IDA		Human	PMID:15269182
Cellular Component	GO:0030496	midbody	SPAST	IMP		Human	PMID:18997780
Cellular Component	GO:0030496	midbody	SPAST	IDA		Human	PMID:21310966
Cellular Component	GO:0031965	nuclear membrane	SPAST	IMP		Human	PMID:26040712
Cellular Component	GO:0005654	nucleoplasm	SPAST	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	SPAST	IDA		Human	PMID:15147984
Cellular Component	GO:0005634	nucleus	SPAST	IDA		Human	PMID:15269182
Cellular Component	GO:0005634	nucleus	SPAST	IDA		Human	PMID:16026783
Cellular Component	GO:0005634	nucleus	SPAST	IDA		Human	PMID:19000169
Cellular Component	GO:0005634	nucleus	Spast	IDA		Mouse	PMID:12490534
Cellular Component	GO:0048471	perinuclear region of cytoplasm	SPAST	IDA		Human	PMID:15147984
Cellular Component	GO:0000922	spindle pole	SPAST	IDA		Human	PMID:15269182
Biological Process	GO:0008089	anterograde axonal transport	Spast	IMP		Mouse	MGI:MGI:3847044|PMID:19453301
Biological Process	GO:0048675	axon extension	spast	IMP	ZFIN:ZDB-MRPHLNO-131010-1	Zfish	PMID:23897888
Biological Process	GO:0048675	axon extension	spast	IGI	ZFIN:ZDB-MRPHLNO-061004-1,ZFIN:ZDB-MRPHLNO-101108-12	Zfish	PMID:20829563
Biological Process	GO:0048675	axon extension	spast	IMP	ZFIN:ZDB-MRPHLNO-061004-1	Zfish	PMID:20829563
Biological Process	GO:0007411	axon guidance	spast	IGI	ZFIN:ZDB-GENE-041010-164	Zfish	PMID:30082270
Biological Process	GO:0007411	axon guidance	spast	IMP	ZFIN:ZDB-MRPHLNO-131010-1	Zfish	PMID:30082270
Biological Process	GO:0007411	axon guidance	spast	IMP	ZFIN:ZDB-MRPHLNO-181210-1	Zfish	PMID:30082270
Biological Process	GO:0007411	axon guidance	spast	IGI	ZFIN:ZDB-GENE-030131-8003	Zfish	PMID:30082270
Biological Process	GO:0019896	axonal transport of mitochondrion	Spast	IMP		Mouse	MGI:MGI:3847044|PMID:19453301
Biological Process	GO:0007409	axonogenesis	spast	IMP	ZFIN:ZDB-MRPHLNO-131010-1	Zfish	PMID:26744324
Biological Process	GO:0007409	axonogenesis	spast	IGI	ZFIN:ZDB-GENE-061013-502	Zfish	PMID:22573551
Biological Process	GO:0007409	axonogenesis	spast	IMP	ZFIN:ZDB-MRPHLNO-061004-2	Zfish	PMID:22573551
Biological Process	GO:0021955	central nervous system neuron axonogenesis	spast	IMP	ZFIN:ZDB-MRPHLNO-061004-1	Zfish	PMID:16893913
Biological Process	GO:0032506	cytokinetic process	SPAST	IMP		Human	PMID:19000169
Biological Process	GO:0031122	cytoplasmic microtubule organization	spast	IMP	ZFIN:ZDB-MRPHLNO-061004-2	Zfish	PMID:20829563
Biological Process	GO:0007029	endoplasmic reticulum organization	spast	IMP	ZFIN:ZDB-GENO-210915-9	Zfish	PMID:32315314
Biological Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	SPAST	IMP		Human	PMID:19000169
Biological Process	GO:0007032	endosome organization	spast	IMP	ZFIN:ZDB-MRPHLNO-131010-1	Zfish	PMID:23897888
Biological Process	GO:0010458	exit from mitosis	SPAST	IMP		Human	PMID:26040712
Biological Process	GO:0034389	lipid droplet organization	spast	IMP	ZFIN:ZDB-GENO-210915-9	Zfish	PMID:32315314
Biological Process	GO:0090148	membrane fission	SPAST	IMP		Human	PMID:21310966
Biological Process	GO:0001578	microtubule bundle formation	SPAST	IDA		Human	PMID:16219033
Biological Process	GO:0000226	microtubule cytoskeleton organization	spast	IMP	ZFIN:ZDB-MRPHLNO-131010-1	Zfish	PMID:26744324
Biological Process	GO:0051013	microtubule severing	SPAST	IDA		Human	PMID:15716377
Biological Process	GO:0051013	microtubule severing	SPAST	IDA		Human	PMID:16219033
Biological Process	GO:0051013	microtubule severing	SPAST	IDA		Human	PMID:17389232
Biological Process	GO:0051013	microtubule severing	SPAST	IMP		Human	PMID:21310966
Biological Process	GO:0051013	microtubule severing	SPAST	IDA		Human	PMID:23745751
Biological Process	GO:0051013	microtubule severing	SPAST	IDA		Human	PMID:26875866
Biological Process	GO:0051013	microtubule severing	Spast	IGI	MGI:MGI:2683461	Mouse	PMID:20530212
Biological Process	GO:0051013	microtubule severing	Spast	IMP		Mouse	PMID:20530212
Biological Process	GO:0051013	microtubule severing	Spast	IDA		Mouse	PMID:20530212
Biological Process	GO:0051013	microtubule severing	Spast	IGI	MGI:MGI:1921660	Mouse	PMID:20530212
Biological Process	GO:0000281	mitotic cytokinesis	SPAST	IMP		Human	PMID:21310966
Biological Process	GO:0051228	mitotic spindle disassembly	SPAST	IMP		Human	PMID:26040712
Biological Process	GO:0043066	negative regulation of apoptotic process	spast	IMP	ZFIN:ZDB-MRPHLNO-061004-1	Zfish	PMID:16893913
Biological Process	GO:0031468	nuclear membrane reassembly	SPAST	IMP		Human	PMID:26040712
Biological Process	GO:0045773	positive regulation of axon extension	spast	IMP	ZFIN:ZDB-MRPHLNO-061004-1	Zfish	PMID:16893913
Biological Process	GO:0032467	positive regulation of cytokinesis	SPAST	IMP		Human	PMID:18997780
Biological Process	GO:0031117	positive regulation of microtubule depolymerization	spast	IMP		Zfish	PMID:16893913
Biological Process	GO:0034214	protein hexamerization	SPAST	IDA		Human	PMID:17389232
Biological Process	GO:0051260	protein homooligomerization	SPAST	IDA		Human	PMID:17389232
Biological Process	GO:0072593	reactive oxygen species metabolic process	spast	IMP	ZFIN:ZDB-MRPHLNO-131010-1	Zfish	PMID:26744324
Biological Process	GO:0048741	skeletal muscle fiber development	spast	IMP	ZFIN:ZDB-GENO-210915-9	Zfish	PMID:32315314

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern