Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPG11
  • Mouse genes Spg11
  • Rat genes Spg11
  • Zfish genes spg11
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spg11

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SPG11	IPI	UniProtKB:O43299	Human	PMID:20613862
Molecular Function	GO:0005515	protein binding	SPG11	IPI	UniProtKB:Q2VPB7	Human	PMID:20613862
Molecular Function	GO:0005515	protein binding	SPG11	IPI	UniProtKB:Q68DK2	Human	PMID:20613862
Molecular Function	GO:0005515	protein binding	SPG11	IPI	UniProtKB:Q9NUS5	Human	PMID:20613862
Molecular Function	GO:0005515	protein binding	SPG11	IPI	UniProtKB:Q9UJW9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPG11	IPI	UniProtKB:Q05193	Human	PMID:29949766
Molecular Function	GO:0019901	protein kinase binding	SPG11	IDA		Human	PMID:25365221
Cellular Component	GO:0030424	axon	Spg11	IDA		Mouse	PMID:24794856
Cellular Component	GO:0005737	cytoplasm	SPG11	IDA		Human	PMID:21545838
Cellular Component	GO:0005737	cytoplasm	Spg11	IDA		Rat	PMID:21545838|RGD:8553773
Cellular Component	GO:0031410	cytoplasmic vesicle	SPG11	IDA		Human	PMID:21545838
Cellular Component	GO:0005829	cytosol	SPG11	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Spg11	IDA		Mouse	MGI:MGI:5585364|PMID:24794856
Cellular Component	GO:0030425	dendrite	Spg11	IDA		Mouse	PMID:24794856
Cellular Component	GO:0005765	lysosomal membrane	SPG11	HDA		Human	PMID:17897319
Cellular Component	GO:0005730	nucleolus	SPG11	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	SPG11	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045202	synapse	SPG11	IDA		Human	PMID:24794856
Cellular Component	GO:0045202	synapse	Spg11	IMP		Mouse	PMID:24794856
Biological Process	GO:1905037	autophagosome organization	SPG11	IDA		Human	PMID:25365221
Biological Process	GO:0008088	axo-dendritic transport	SPG11	IMP		Human	PMID:24794856
Biological Process	GO:0008088	axo-dendritic transport	Spg11	IMP		Mouse	PMID:24794856
Biological Process	GO:0048675	axon extension	Spg11	IMP		Mouse	PMID:24794856
Biological Process	GO:0007409	axonogenesis	spg11	IGI	ZFIN:ZDB-MRPHLNO-121220-2,ZFIN:ZDB-MRPHLNO-121220-3	Zfish	PMID:22801083
Biological Process	GO:0007409	axonogenesis	spg11	IMP	ZFIN:ZDB-MRPHLNO-121220-3	Zfish	PMID:22801083
Biological Process	GO:0007268	chemical synaptic transmission	SPG11	IMP		Human	PMID:24794856
Biological Process	GO:0033344	cholesterol efflux	Spg11	IMP	MGI:MGI:6451766	Mouse	PMID:28237315
Biological Process	GO:0033344	cholesterol efflux	Spg11	IMP	MGI:MGI:6451766	Mouse	PMID:31637311
Biological Process	GO:0021957	corticospinal tract morphogenesis	Spg11	IMP	MGI:MGI:6451766	Mouse	PMID:28237315
Biological Process	GO:0051668	localization within membrane	Spg11	IMP	MGI:MGI:6451766	Mouse	PMID:31637311
Biological Process	GO:0007040	lysosome organization	SPG11	IDA		Human	PMID:25365221
Biological Process	GO:0007040	lysosome organization	Spg11	IMP	MGI:MGI:6451766	Mouse	PMID:31637311
Biological Process	GO:0007040	lysosome organization	Spg11	IMP	MGI:MGI:6451766	Mouse	PMID:28237315
Biological Process	GO:0007040	lysosome organization	Spg11	IMP	MGI:MGI:4377985	Mouse	PMID:26284655
Biological Process	GO:0007613	memory	Spg11	IMP	MGI:MGI:6451766	Mouse	PMID:28237315
Biological Process	GO:0061744	motor behavior	Spg11	IMP	MGI:MGI:6451766	Mouse	PMID:28237315
Biological Process	GO:0097049	motor neuron apoptotic process	Spg11	IMP	MGI:MGI:6451766	Mouse	PMID:28237315
Biological Process	GO:0007399	nervous system development	spg11	IMP	ZFIN:ZDB-MRPHLNO-101017-2	Zfish	PMID:20390432
Biological Process	GO:0007399	nervous system development	spg11	IMP	ZFIN:ZDB-MRPHLNO-101017-1	Zfish	PMID:20390432
Biological Process	GO:0007528	neuromuscular junction development	Spg11	IMP	MGI:MGI:6451766	Mouse	PMID:28237315
Biological Process	GO:0051402	neuron apoptotic process	Spg11	IMP	MGI:MGI:6451766	Mouse	PMID:28237315
Biological Process	GO:0090389	phagosome-lysosome fusion involved in apoptotic cell clearance	Spg11	IMP	MGI:MGI:4377985	Mouse	PMID:26284655
Biological Process	GO:0006606	protein import into nucleus	Spg11	IMP	MGI:MGI:6451766	Mouse	PMID:31637311
Biological Process	GO:2001256	regulation of store-operated calcium entry	Spg11	IMP	MGI:MGI:6451766	Mouse	PMID:31637311
Biological Process	GO:0048741	skeletal muscle fiber development	Spg11	IMP	MGI:MGI:6451766	Mouse	PMID:28237315
Biological Process	GO:0036269	swimming behavior	spg11	IMP	ZFIN:ZDB-MRPHLNO-121220-3	Zfish	PMID:29949766
Biological Process	GO:0048489	synaptic vesicle transport	SPG11	IMP		Human	PMID:24794856
Biological Process	GO:0001966	thigmotaxis	spg11	IMP	ZFIN:ZDB-MRPHLNO-121220-3	Zfish	PMID:29949766
Biological Process	GO:0090659	walking behavior	Spg11	IMP	MGI:MGI:4377985	Mouse	PMID:26284655

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern