Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPG7
  • Mouse genes Spg7
  • Rat genes Spg7
  • Zfish genes spg7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spg7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004222	metalloendopeptidase activity	SPG7	IDA		Human	PMID:11549317
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:Q9Y4W6	Human	PMID:14623864
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:Q99750	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:Q5JR59	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:Q8ND90	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:O43586	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:O95273	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:P60409	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:P60411	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:P61289	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:P61978	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:Q5JR59	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:Q5VWX1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:Q8ND90	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:Q93062	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:Q99750	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:Q9BRK4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:P21796|UniProtKB:P30405|UniProtKB:Q9Y4W6	Human	PMID:26387735
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:O75031	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:P61978-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:Q8ND90	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPG7	IPI	UniProtKB:Q99750	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Spg7	IPI	UniProtKB:Q8JZQ2|UniProtKB:Q920A7	Mouse	MGI:MGI:4833943|PMID:19656850
Cellular Component	GO:0005745	m-AAA complex	Spg7	IDA		Mouse	PMID:19656850
Cellular Component	GO:0005743	mitochondrial inner membrane	Spg7	IDA		Mouse	MGI:MGI:4833943|PMID:19656850
Cellular Component	GO:0005757	mitochondrial permeability transition pore complex	SPG7	IDA		Human	PMID:26387735
Cellular Component	GO:0005739	mitochondrion	Spg7	IDA		Mouse	PMID:19656850
Cellular Component	GO:0005739	mitochondrion	Spg7	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Spg7	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Spg7	IDA		Mouse	PMID:14722615
Biological Process	GO:0008089	anterograde axonal transport	Spg7	IMP	MGI:MGI:3028923	Mouse	PMID:14722615
Biological Process	GO:1902686	mitochondrial outer membrane permeabilization involved in programmed cell death	SPG7	IMP		Human	PMID:26387735
Biological Process	GO:1902686	mitochondrial outer membrane permeabilization involved in programmed cell death	Spg7	IMP		Rat	PMID:26387735|RGD:13441202
Biological Process	GO:0007005	mitochondrion organization	Spg7	IMP	MGI:MGI:3028923	Mouse	PMID:14722615
Biological Process	GO:0046902	regulation of mitochondrial membrane permeability	SPG7	IMP		Human	PMID:26387735
Biological Process	GO:0046902	regulation of mitochondrial membrane permeability	Spg7	IMP		Rat	PMID:26387735|RGD:13441202

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern