Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPHK1
  • Mouse genes Sphk1
  • Rat genes Sphk1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sphk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016407	acetyltransferase activity	Sphk1	IMP		Mouse	MGI:MGI:6158194|PMID:29662056
Molecular Function	GO:0005524	ATP binding	SPHK1	IDA		Human	PMID:12393916
Molecular Function	GO:0005516	calmodulin binding	SPHK1	IDA		Human	PMID:10947957
Molecular Function	GO:0005516	calmodulin binding	SPHK1	IDA		Human	PMID:12393916
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	SPHK1	IDA		Human	PMID:10863092
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	SPHK1	IDA		Human	PMID:11923095
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	SPHK1	IDA		Human	PMID:20577214
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	Sphk1	IDA		Mouse	MGI:MGI:1278076|PMID:9726979
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	Sphk1	IDA		Mouse	MGI:MGI:6282951|PMID:21084291
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	Sphk1	IDA		Rat	PMID:15715670|RGD:2311352
Molecular Function	GO:0003677	DNA binding	SPHK1	IDA		Human	PMID:12393916
Molecular Function	GO:0008289	lipid binding	SPHK1	IDA		Human	PMID:24929359
Molecular Function	GO:0000287	magnesium ion binding	SPHK1	IDA		Human	PMID:10947957
Molecular Function	GO:0005515	protein binding	SPHK1	IPI	UniProtKB:Q2M3C7	Human	PMID:12080051
Molecular Function	GO:0005515	protein binding	SPHK1	IPI	UniProtKB:Q14192	Human	PMID:16888242
Molecular Function	GO:0005515	protein binding	SPHK1	IPI	UniProtKB:P07858	Human	PMID:17064696
Molecular Function	GO:0005515	protein binding	SPHK1	IPI	UniProtKB:Q9Y4K3	Human	PMID:17124500
Molecular Function	GO:0005515	protein binding	SPHK1	IPI	UniProtKB:P68104	Human	PMID:18263879
Molecular Function	GO:0005515	protein binding	SPHK1	IPI	UniProtKB:Q99828	Human	PMID:19854831
Molecular Function	GO:0005515	protein binding	SPHK1	IPI	UniProtKB:P68104	Human	PMID:20838377
Molecular Function	GO:0005515	protein binding	Sphk1	IPI	RGD:61963	Rat	PMID:16888242|RGD:2311372
Molecular Function	GO:0051721	protein phosphatase 2A binding	SPHK1	IPI	UniProtKB:Q15172	Human	PMID:21075214
Molecular Function	GO:0008481	sphinganine kinase activity	SPHK1	IDA		Human	PMID:12393916
Molecular Function	GO:0008481	sphinganine kinase activity	SPHK1	IDA		Human	PMID:15623571
Molecular Function	GO:0008481	sphinganine kinase activity	SPHK1	IDA		Human	PMID:24929359
Molecular Function	GO:0008481	sphinganine kinase activity	SPHK1	IDA		Human	PMID:25417698
Molecular Function	GO:0008481	sphinganine kinase activity	Sphk1	IDA		Mouse	MGI:MGI:6210668|PMID:25417698
Molecular Function	GO:0008481	sphinganine kinase activity	Sphk1	IDA		Mouse	MGI:MGI:6690342|PMID:33334894
Molecular Function	GO:0038036	sphingosine-1-phosphate receptor activity	SPHK1	IMP		Human	PMID:23106337
Cellular Component	GO:0030424	axon	Sphk1	IDA		Rat	PMID:17325039|RGD:2311366
Cellular Component	GO:0005905	clathrin-coated pit	SPHK1	IDA		Human	PMID:24929359
Cellular Component	GO:0005737	cytoplasm	SPHK1	IDA		Human	PMID:15623571
Cellular Component	GO:0005737	cytoplasm	SPHK1	IDA		Human	PMID:19854831
Cellular Component	GO:0005737	cytoplasm	SPHK1	IDA		Human	PMID:21075214
Cellular Component	GO:0005737	cytoplasm	Sphk1	IDA		Mouse	MGI:MGI:6294167|PMID:16118219
Cellular Component	GO:0005737	cytoplasm	Sphk1	IDA		Mouse	MGI:MGI:6158194|PMID:29662056
Cellular Component	GO:0005737	cytoplasm	Sphk1	IMP		Mouse	MGI:MGI:5896700|PMID:27806293
Cellular Component	GO:0005829	cytosol	SPHK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Sphk1	IDA		Rat	PMID:18761669|RGD:2311351
Cellular Component	GO:0031901	early endosome membrane	SPHK1	IDA		Human	PMID:24929359
Cellular Component	GO:0030139	endocytic vesicle	Sphk1	IDA		Mouse	MGI:MGI:5896700|PMID:27806293
Cellular Component	GO:0043005	neuron projection	Sphk1	IDA		Rat	PMID:17325039|RGD:2311366
Cellular Component	GO:0005634	nucleus	Sphk1	IDA		Mouse	MGI:MGI:6158194|PMID:29662056
Cellular Component	GO:0005886	plasma membrane	SPHK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	SPHK1	IDA		Human	PMID:19854831
Cellular Component	GO:0005886	plasma membrane	SPHK1	IDA		Human	PMID:21075214
Cellular Component	GO:0005886	plasma membrane	Sphk1	IDA		Rat	PMID:19357361|RGD:2311350
Cellular Component	GO:0098793	presynapse	Sphk1	IDA		Mouse	MGI:MGI:5620589|PMID:24929359
Cellular Component	GO:0008021	synaptic vesicle	Sphk1	IDA		Rat	PMID:17325039|RGD:2311366
Biological Process	GO:0001568	blood vessel development	Sphk1	IGI	MGI:MGI:1861380	Mouse	PMID:16314531
Biological Process	GO:0007420	brain development	Sphk1	IGI	MGI:MGI:1861380	Mouse	PMID:16314531
Biological Process	GO:0019722	calcium-mediated signaling	SPHK1	IDA		Human	PMID:10947957
Biological Process	GO:0008283	cell population proliferation	Sphk1	IGI	MGI:MGI:1861380	Mouse	PMID:16314531
Biological Process	GO:0071363	cellular response to growth factor stimulus	Sphk1	IEP		Rat	PMID:16135093|RGD:2311349
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Sphk1	IDA		Mouse	PMID:23651497
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Sphk1	IEP		Rat	PMID:17158340|RGD:2311369
Biological Process	GO:0009267	cellular response to starvation	Sphk1	IEP		Rat	PMID:16959847|RGD:2311370
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	SPHK1	IDA		Human	PMID:25417698
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	Sphk1	IDA		Mouse	MGI:MGI:6210668|PMID:25417698
Biological Process	GO:0019371	cyclooxygenase pathway	Sphk1	IDA		Rat	PMID:18723875|RGD:2311353
Biological Process	GO:0071897	DNA biosynthetic process	Sphk1	IMP		Mouse	PMID:23651497
Biological Process	GO:0007565	female pregnancy	Sphk1	IEP		Rat	PMID:18723875|RGD:2311353
Biological Process	GO:0006954	inflammatory response	Sphk1	IMP	MGI:MGI:3526071	Mouse	PMID:18305483
Biological Process	GO:0043066	negative regulation of apoptotic process	SPHK1	IDA		Human	PMID:15623571
Biological Process	GO:0043066	negative regulation of apoptotic process	SPHK1	IMP		Human	PMID:16118219
Biological Process	GO:0043066	negative regulation of apoptotic process	Sphk1	IDA		Mouse	MGI:MGI:6294167|PMID:16118219
Biological Process	GO:0043066	negative regulation of apoptotic process	Sphk1	IMP		Rat	PMID:17158340|RGD:2311369
Biological Process	GO:1900060	negative regulation of ceramide biosynthetic process	SPHK1	IDA		Human	PMID:16118219
Biological Process	GO:1900060	negative regulation of ceramide biosynthetic process	Sphk1	IMP		Mouse	MGI:MGI:6294167|PMID:16118219
Biological Process	GO:0016310	phosphorylation	Sphk1	IDA		Mouse	MGI:MGI:1278076|PMID:9726979
Biological Process	GO:0045766	positive regulation of angiogenesis	SPHK1	IDA		Human	PMID:12441135
Biological Process	GO:0030307	positive regulation of cell growth	SPHK1	IDA		Human	PMID:12441135
Biological Process	GO:0030335	positive regulation of cell migration	SPHK1	IDA		Human	PMID:12441135
Biological Process	GO:0030335	positive regulation of cell migration	Sphk1	IMP		Rat	PMID:17200676|RGD:2311367
Biological Process	GO:0008284	positive regulation of cell population proliferation	Sphk1	IGI	MGI:MGI:1861380	Mouse	PMID:16314531
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	SPHK1	IDA		Human	PMID:15623571
Biological Process	GO:0032740	positive regulation of interleukin-17 production	Sphk1	IMP		Rat	PMID:28284343|RGD:14397556
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	SPHK1	IDA		Human	PMID:12441135
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	Sphk1	IGI	MGI:MGI:1927578	Mouse	PMID:23651497
Biological Process	GO:0010976	positive regulation of neuron projection development	Sphk1	IMP		Rat	PMID:15289497|RGD:2311375
Biological Process	GO:0001956	positive regulation of neurotransmitter secretion	Sphk1	IMP		Rat	PMID:17325039|RGD:2311366
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	SPHK1	IMP		Human	PMID:20577214
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Sphk1	IMP		Rat	PMID:28284343|RGD:14397556
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	SPHK1	IMP		Human	PMID:20577214
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	SPHK1	IDA		Human	PMID:23935096
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	SPHK1	IMP		Human	PMID:23106337
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Sphk1	IMP		Rat	PMID:16313513|RGD:2311373
Biological Process	GO:0031398	positive regulation of protein ubiquitination	SPHK1	IDA		Human	PMID:20577214
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	SPHK1	IDA		Human	PMID:12847068
Biological Process	GO:0006473	protein acetylation	Sphk1	IMP		Mouse	MGI:MGI:6158194|PMID:29662056
Biological Process	GO:0030100	regulation of endocytosis	SPHK1	IDA		Human	PMID:24929359
Biological Process	GO:0030100	regulation of endocytosis	SPHK1	IDA		Human	PMID:28049734
Biological Process	GO:0030100	regulation of endocytosis	Sphk1	IMP		Mouse	MGI:MGI:6294176|PMID:28049734
Biological Process	GO:0030100	regulation of endocytosis	Sphk1	IMP		Mouse	MGI:MGI:5896700|PMID:27806293
Biological Process	GO:1905364	regulation of endosomal vesicle fusion	Sphk1	IMP		Mouse	MGI:MGI:5896700|PMID:27806293
Biological Process	GO:0032651	regulation of interleukin-1 beta production	Sphk1	IMP	MGI:MGI:3526071	Mouse	PMID:18305483
Biological Process	GO:1903978	regulation of microglial cell activation	Sphk1	IMP		Mouse	MGI:MGI:6158194|PMID:29662056
Biological Process	GO:0150077	regulation of neuroinflammatory response	Sphk1	IMP		Mouse	MGI:MGI:6158194|PMID:29662056
Biological Process	GO:0150077	regulation of neuroinflammatory response	Sphk1	IMP		Rat	PMID:28284343|RGD:14397556
Biological Process	GO:0050764	regulation of phagocytosis	Sphk1	IMP		Mouse	MGI:MGI:6158194|PMID:29662056
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	SPHK1	IDA		Human	PMID:20577214
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	Sphk1	IMP		Rat	PMID:28284343|RGD:14397556
Biological Process	GO:0014075	response to amine	Sphk1	IEP		Rat	PMID:17164439|RGD:2311368
Biological Process	GO:0033198	response to ATP	Sphk1	IEP		Rat	PMID:17200676|RGD:2311367
Biological Process	GO:0070555	response to interleukin-1	Sphk1	IEP		Rat	PMID:15855330|RGD:2311374
Biological Process	GO:0032026	response to magnesium ion	Sphk1	IEP		Rat	PMID:18028875|RGD:2311354
Biological Process	GO:0014070	response to organic cyclic compound	Sphk1	IEP		Rat	PMID:15715670|RGD:2311352
Biological Process	GO:0032570	response to progesterone	Sphk1	IEP		Rat	PMID:17164439|RGD:2311368
Biological Process	GO:0034612	response to tumor necrosis factor	SPHK1	IDA		Human	PMID:23935096
Biological Process	GO:0090520	sphingolipid mediated signaling pathway	Sphk1	IDA		Mouse	PMID:23651497
Biological Process	GO:0046512	sphingosine biosynthetic process	SPHK1	IGI	UniProtKB:Q9NRA0	Human	PMID:23106337
Biological Process	GO:0046512	sphingosine biosynthetic process	SPHK1	IMP		Human	PMID:23106337
Biological Process	GO:0006670	sphingosine metabolic process	SPHK1	IDA		Human	PMID:20577214

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern