Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Sphk2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SPHK2
- Mouse genes Sphk2
- Rat genes Sphk2
- Zfish genes sphk2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sphk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	SPHK2	IDA		Human	PMID:10751414
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	Sphk2	IDA		Mouse	MGI:MGI:6282951\|PMID:21084291
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	Sphk2	IMP		Mouse	MGI:MGI:3703830\|PMID:17346996
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	Sphk2	IDA		Mouse	PMID:10751414
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	Sphk2	IMP	MGI:MGI:3580701	Mouse	PMID:16093248
Molecular Function	GO:0042393	histone binding	SPHK2	IDA		Human	PMID:19729656
Molecular Function	GO:0005515	protein binding	SPHK2	IPI	UniProtKB:Q12933	Human	PMID:11777919
Molecular Function	GO:0005515	protein binding	SPHK2	IPI	UniProtKB:P68104	Human	PMID:18263879
Molecular Function	GO:0005515	protein binding	SPHK2	IPI	UniProtKB:Q13547,UniProtKB:Q92769,UniProtKB:Q96ST3,UniProtKB:Q9UBB5	Human	PMID:19729656
Molecular Function	GO:0005515	protein binding	SPHK2	IPI	UniProtKB:Q96CV9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Sphk2	IPI	UniProtKB:O35129	Mouse	MGI:MGI:6294409\|PMID:20959514
Molecular Function	GO:0005515	protein binding	Sphk2	IPI	UniProtKB:P39688	Mouse	MGI:MGI:3843433\|PMID:16316995
Molecular Function	GO:0008481	sphinganine kinase activity	SPHK2	IDA		Human	PMID:19729656
Molecular Function	GO:0038036	sphingosine-1-phosphate receptor activity	SPHK2	IMP		Human	PMID:23106337
Cellular Component	GO:0005737	cytoplasm	SPHK2	IDA		Human	PMID:17635916
Cellular Component	GO:0005737	cytoplasm	SPHK2	IDA		Human	PMID:29615132
Cellular Component	GO:0005737	cytoplasm	Sphk2	IDA		Mouse	MGI:MGI:6294167\|PMID:16118219
Cellular Component	GO:0005829	cytosol	SPHK2	IDA		Human	PMID:10751414
Cellular Component	GO:0005829	cytosol	Sphk2	IDA		Mouse	MGI:MGI:1860308\|PMID:10751414
Cellular Component	GO:0005783	endoplasmic reticulum	Sphk2	IDA		Mouse	MGI:MGI:6294167\|PMID:16118219
Cellular Component	GO:0005765	lysosomal membrane	SPHK2	HDA		Human	PMID:17897319
Cellular Component	GO:0016020	membrane	SPHK2	IDA		Human	PMID:10751414
Cellular Component	GO:0016020	membrane	Sphk2	IDA		Mouse	MGI:MGI:1860308\|PMID:10751414
Cellular Component	GO:0005743	mitochondrial inner membrane	Sphk2	IDA		Mouse	MGI:MGI:6294409\|PMID:20959514
Cellular Component	GO:0005739	mitochondrion	Sphk2	IDA		Mouse	MGI:MGI:5641585\|PMID:25637806
Cellular Component	GO:0005654	nucleoplasm	SPHK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000786	nucleosome	SPHK2	IDA		Human	PMID:19729656
Cellular Component	GO:0005634	nucleus	SPHK2	IDA		Human	PMID:17635916
Cellular Component	GO:0005634	nucleus	SPHK2	IDA		Human	PMID:29615132
Cellular Component	GO:0005634	nucleus	Sphk2	IDA		Mouse	MGI:MGI:6294409\|PMID:20959514
Biological Process	GO:0001568	blood vessel development	Sphk2	IGI	MGI:MGI:1316649	Mouse	PMID:16314531
Biological Process	GO:0007420	brain development	Sphk2	IGI	MGI:MGI:1316649	Mouse	PMID:16314531
Biological Process	GO:0003318	cell migration to the midline involved in heart development	sphk2	IMP	ZFIN:ZDB-GENO-151230-5	Zfish	PMID:25997406
Biological Process	GO:0008283	cell population proliferation	Sphk2	IGI	MGI:MGI:1316649	Mouse	PMID:16314531
Biological Process	GO:0106097	cellular response to ceramide	sphk2	IGI	ZFIN:ZDB-GENO-180830-1	Zfish	PMID:28956531
Biological Process	GO:1904628	cellular response to phorbol 13-acetate 12-myristate	SPHK2	IDA		Human	PMID:17635916
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	sphk2	IMP	ZFIN:ZDB-GENO-151007-3	Zfish	PMID:25907554
Biological Process	GO:0007565	female pregnancy	Sphk2	IEP		Rat	PMID:18723875\|RGD:2311353
Biological Process	GO:0003007	heart morphogenesis	sphk2	IMP	ZFIN:ZDB-GENO-151007-7,ZFIN:ZDB-MRPHLNO-150923-1	Zfish	PMID:25907554
Biological Process	GO:0003007	heart morphogenesis	sphk2	IMP	ZFIN:ZDB-GENO-151007-3	Zfish	PMID:25907554
Biological Process	GO:0046834	lipid phosphorylation	Sphk2	IMP	MGI:MGI:3580701	Mouse	MGI:MGI:3608224\|PMID:16093248
Biological Process	GO:0030308	negative regulation of cell growth	Sphk2	IDA		Mouse	MGI:MGI:6294167\|PMID:16118219
Biological Process	GO:0043065	positive regulation of apoptotic process	SPHK2	IDA		Human	PMID:16118219
Biological Process	GO:0043065	positive regulation of apoptotic process	Sphk2	IDA		Mouse	MGI:MGI:6294167\|PMID:16118219
Biological Process	GO:0090280	positive regulation of calcium ion import	Sphk2	IMP		Mouse	MGI:MGI:3703830\|PMID:17346996
Biological Process	GO:0008284	positive regulation of cell population proliferation	Sphk2	IGI	MGI:MGI:1316649	Mouse	PMID:16314531
Biological Process	GO:2000304	positive regulation of ceramide biosynthetic process	SPHK2	IDA		Human	PMID:16118219
Biological Process	GO:2000304	positive regulation of ceramide biosynthetic process	Sphk2	IDA		Mouse	MGI:MGI:6294167\|PMID:16118219
Biological Process	GO:0002720	positive regulation of cytokine production involved in immune response	Sphk2	IMP		Mouse	MGI:MGI:3703830\|PMID:17346996
Biological Process	GO:0032736	positive regulation of interleukin-13 production	Sphk2	IMP		Mouse	MGI:MGI:3703830\|PMID:17346996
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Sphk2	IMP		Mouse	MGI:MGI:3703830\|PMID:17346996
Biological Process	GO:0033008	positive regulation of mast cell activation involved in immune response	Sphk2	IMP		Mouse	MGI:MGI:3703830\|PMID:17346996
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Sphk2	IMP		Mouse	MGI:MGI:3703830\|PMID:17346996
Biological Process	GO:0090037	positive regulation of protein kinase C signaling	Sphk2	IMP		Mouse	MGI:MGI:3703830\|PMID:17346996
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Sphk2	IMP		Mouse	MGI:MGI:3703830\|PMID:17346996
Biological Process	GO:2001169	regulation of ATP biosynthetic process	Sphk2	IMP		Mouse	MGI:MGI:5641585\|PMID:25637806
Biological Process	GO:1904959	regulation of cytochrome-c oxidase activity	SPHK2	IMP		Human	PMID:20959514
Biological Process	GO:1904959	regulation of cytochrome-c oxidase activity	Sphk2	IMP		Mouse	MGI:MGI:6294409\|PMID:20959514
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	Sphk2	IMP		Mouse	MGI:MGI:3703830\|PMID:17346996
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process	Sphk2	IMP		Mouse	MGI:MGI:5641585\|PMID:25637806
Biological Process	GO:0006669	sphinganine-1-phosphate biosynthetic process	SPHK2	IDA		Human	PMID:10751414
Biological Process	GO:0006669	sphinganine-1-phosphate biosynthetic process	SPHK2	IDA		Human	PMID:19729656
Biological Process	GO:0006669	sphinganine-1-phosphate biosynthetic process	Sphk2	IDA		Mouse	MGI:MGI:1860308\|PMID:10751414
Biological Process	GO:0090520	sphingolipid mediated signaling pathway	sphk2	IGI	ZFIN:ZDB-GENO-191121-8	Zfish	PMID:30718751
Biological Process	GO:0046512	sphingosine biosynthetic process	SPHK2	IGI	UniProtKB:Q9NYA1	Human	PMID:23106337
Biological Process	GO:0046512	sphingosine biosynthetic process	SPHK2	IMP		Human	PMID:23106337
Biological Process	GO:0006670	sphingosine metabolic process	Sphk2	IMP		Mouse	MGI:MGI:3703830\|PMID:17346996
Biological Process	GO:0006670	sphingosine metabolic process	Sphk2	IMP	MGI:MGI:3580701	Mouse	PMID:16093248
Biological Process	GO:0006670	sphingosine metabolic process	sphk2	IMP		Zfish	PMID:28956531
Biological Process	GO:0045815	transcription initiation-coupled chromatin remodeling	SPHK2	IDA		Human	PMID:19729656

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.