Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPIC
  • Mouse genes Spic
  • Rat genes Spic
  • Zfish genes spic
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spic

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Spic	IMP		Mouse	MGI:MGI:5825434|PMID:12749910
Molecular Function	GO:0005515	protein binding	SPIC	IPI	UniProtKB:P50221	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPIC	IPI	UniProtKB:Q5TA45	Human	PMID:32296183
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Spic	IMP		Mouse	MGI:MGI:5825434|PMID:12749910
Biological Process	GO:0001824	blastocyst development	Spic	IMP		Mouse	PMID:16630543
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Spic	IMP		Mouse	MGI:MGI:5825434|PMID:12749910
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Spic	IGI	MGI:MGI:1101781	Mouse	PMID:16630543
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Spic	IGI	MGI:MGI:99253	Mouse	PMID:16630543

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern