Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPINK1
  • Mouse genes Spink1
  • Rat genes Spink1,Spink1l
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spink1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030414	peptidase inhibitor activity	Spink1	IDA		Mouse	PMID:3428272
Molecular Function	GO:0005515	protein binding	SPINK1	IPI	UniProtKB:P35030	Human	PMID:14507909
Molecular Function	GO:0005515	protein binding	SPINK1	IPI	UniProtKB:Q12797-6	Human	PMID:32296183
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	Spink1	IMP	MGI:MGI:3613294	Mouse	PMID:20110462
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	Spink1	IDA		Mouse	PMID:18715980
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	Spink1	IDA		Mouse	PMID:22228629
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	Spink1	IDA		Rat	PMID:12771515|RGD:724699
Cellular Component	GO:0005737	cytoplasm	Spink1	IDA		Rat	PMID:15765407|RGD:10043090
Cellular Component	GO:0070062	extracellular exosome	SPINK1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	Spink1	IDA		Mouse	PMID:18715980
Cellular Component	GO:0005615	extracellular space	Spink1	IDA		Rat	PMID:7526044|RGD:10043093
Biological Process	GO:0007568	aging	Spink1l	IEP		Rat	PMID:15153788|RGD:10044259
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	Spink1	IEP		Rat	PMID:1379547|RGD:10044256
Biological Process	GO:0090281	negative regulation of calcium ion import	Spink1	IDA		Mouse	PMID:2430282
Biological Process	GO:0090281	negative regulation of calcium ion import	Spink1	IDA		Mouse	PMID:22228629
Biological Process	GO:0010751	negative regulation of nitric oxide mediated signal transduction	Spink1	IDA		Mouse	PMID:22228629
Biological Process	GO:0010466	negative regulation of peptidase activity	Spink1	IDA		Mouse	PMID:3428272
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	Spink1	IDA		Mouse	PMID:22228629
Biological Process	GO:1900004	negative regulation of serine-type endopeptidase activity	Spink1	IMP	MGI:MGI:3613294	Mouse	PMID:20110462
Biological Process	GO:1900004	negative regulation of serine-type endopeptidase activity	Spink1	IDA		Mouse	PMID:22228629
Biological Process	GO:1900004	negative regulation of serine-type endopeptidase activity	Spink1	IDA		Rat	PMID:12771515|RGD:724699
Biological Process	GO:0007263	nitric oxide mediated signal transduction	Spink1	IDA		Mouse	PMID:22228629
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Spink1	IDA		Mouse	PMID:22228629
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Spink1	IDA		Rat	PMID:1594624|RGD:10044258
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Spink1	IDA		Rat	PMID:9693203|RGD:10044254
Biological Process	GO:0090187	positive regulation of pancreatic juice secretion	Spink1	IDA		Rat	PMID:2755938|RGD:10044250
Biological Process	GO:0090277	positive regulation of peptide hormone secretion	Spink1	IDA		Rat	PMID:2755938|RGD:10044250
Biological Process	GO:0060046	regulation of acrosome reaction	Spink1	IDA		Mouse	PMID:22228629
Biological Process	GO:2001256	regulation of store-operated calcium entry	Spink1	IDA		Mouse	PMID:22228629
Biological Process	GO:0045471	response to ethanol	Spink1	IEP		Rat	PMID:11484913|RGD:10044246
Biological Process	GO:0031667	response to nutrient levels	Spink1	IEP		Rat	PMID:2065678|RGD:634102
Biological Process	GO:0048240	sperm capacitation	Spink1	IDA		Mouse	PMID:22228629

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern