Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPINK2
  • Mouse genes Spink2
  • Rat genes Spink2
  • Zfish genes spink2.1,spink2.10,spink2.11,spink2.2,spink2.3,spink2.4,spink2.5,spink2.6,spink2.7,spink2.8,spink2.9
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spink2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SPINK2	IPI	UniProtKB:P26371	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPINK2	IPI	UniProtKB:Q6UY14-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPINK2	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPINK2	IPI	UniProtKB:Q9Y5K2	Human	PMID:31391482
Molecular Function	GO:0005515	protein binding	SPINK2	IPI	UniProtKB:P49788	Human	PMID:31886233
Molecular Function	GO:0005515	protein binding	SPINK2	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPINK2	IPI	UniProtKB:P28799	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Spink2	IPI	PR:Q9JLI7	Mouse	PMID:31146259
Cellular Component	GO:0001669	acrosomal vesicle	SPINK2	IDA		Human	PMID:28554943
Cellular Component	GO:0001669	acrosomal vesicle	Spink2	IDA		Mouse	MGI:MGI:6114299|PMID:28554943
Cellular Component	GO:0001669	acrosomal vesicle	Spink2	IDA		Mouse	PMID:21705336
Cellular Component	GO:0001669	acrosomal vesicle	Spink2	IDA		Mouse	PMID:31146259
Cellular Component	GO:0005737	cytoplasm	Spink2	IDA		Mouse	PMID:21705336
Cellular Component	GO:0043005	neuron projection	Spink2	IDA		Mouse	PMID:24699552
Biological Process	GO:0001675	acrosome assembly	Spink2	IMP		Mouse	MGI:MGI:6114299|PMID:28554943
Biological Process	GO:0009566	fertilization	Spink2	IMP	MGI:MGI:4966113	Mouse	PMID:21705336
Biological Process	GO:0002176	male germ cell proliferation	Spink2	IMP	MGI:MGI:4966113	Mouse	PMID:21705336
Biological Process	GO:0008584	male gonad development	Spink2	IMP	MGI:MGI:4966113	Mouse	PMID:21705336
Biological Process	GO:1900004	negative regulation of serine-type endopeptidase activity	Spink2	IDA		Mouse	PMID:21705336
Biological Process	GO:0043065	positive regulation of apoptotic process	Spink2	IDA		Mouse	PMID:24699552
Biological Process	GO:0072520	seminiferous tubule development	Spink2	IMP	MGI:MGI:4966113	Mouse	PMID:21705336
Biological Process	GO:0007286	spermatid development	SPINK2	IMP		Human	PMID:28554943
Biological Process	GO:0007286	spermatid development	Spink2	IMP		Mouse	MGI:MGI:6114299|PMID:28554943
Biological Process	GO:0007286	spermatid development	Spink2	IMP	MGI:MGI:4966113	Mouse	PMID:21705336
Biological Process	GO:0007283	spermatogenesis	Spink2	IMP	MGI:MGI:4966113	Mouse	PMID:21705336

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern