Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPINK5
  • Mouse genes Spink5
  • Rat genes Spink5
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spink5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030414	peptidase inhibitor activity	Spink5	IMP		Mouse	PMID:15466487
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SPINK5	IDA		Human	PMID:10419450
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SPINK5	IDA		Human	PMID:15680911
Cellular Component	GO:0005938	cell cortex	SPINK5	IDA		Human	PMID:12915442
Cellular Component	GO:0005737	cytoplasm	SPINK5	IDA		Human	PMID:12915442
Cellular Component	GO:0005829	cytosol	SPINK5	IDA		Human	PMID:15680911
Cellular Component	GO:0005783	endoplasmic reticulum	SPINK5	IDA		Human	PMID:15680911
Cellular Component	GO:0005789	endoplasmic reticulum membrane	SPINK5	IDA		Human	PMID:15680911
Cellular Component	GO:0097209	epidermal lamellar body	SPINK5	IDA		Human	PMID:15675955
Cellular Component	GO:0005576	extracellular region	SPINK5	IDA		Human	PMID:15680911
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	SPINK5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0048471	perinuclear region of cytoplasm	SPINK5	IDA		Human	PMID:15680911
Biological Process	GO:0009913	epidermal cell differentiation	SPINK5	IDA		Human	PMID:12915442
Biological Process	GO:0002787	negative regulation of antibacterial peptide production	Spink5	IMP		Mouse	MGI:MGI:3770082|PMID:17012259
Biological Process	GO:0045861	negative regulation of proteolysis	Spink5	IMP		Mouse	PMID:15466487
Biological Process	GO:1900004	negative regulation of serine-type endopeptidase activity	Spink5	IMP		Mouse	MGI:MGI:3770082|PMID:17012259
Biological Process	GO:1902572	negative regulation of serine-type peptidase activity	Spink5	IMP	MGI:MGI:3573756	Mouse	PMID:20179351
Biological Process	GO:0030155	regulation of cell adhesion	Spink5	IMP		Mouse	PMID:15466487

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern