Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPIRE1
  • Mouse genes Spire1
  • Rat genes Spire1
  • Zfish genes spire1a,spire1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spire1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SPIRE1	IPI	UniProtKB:Q96RK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPIRE1	IPI	UniProtKB:P13637	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPIRE1	IPI	UniProtKB:P16284	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPIRE1	IPI	UniProtKB:Q13393	Human	PMID:32814053
Cellular Component	GO:0005938	cell cortex	Spire1	IDA		Mouse	MGI:MGI:5305386|PMID:21983562
Cellular Component	GO:0032154	cleavage furrow	Spire1	IDA		Mouse	MGI:MGI:5050782|PMID:21620703
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	Spire1	IDA		Mouse	MGI:MGI:5305386|PMID:21983562
Cellular Component	GO:0005829	cytosol	SPIRE1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	Spire1	IDA		Mouse	PMID:11747823
Cellular Component	GO:0005741	mitochondrial outer membrane	SPIRE1	IDA		Human	PMID:26305500
Cellular Component	GO:0005741	mitochondrial outer membrane	Spire1	IDA		Mouse	MGI:MGI:5698602|PMID:26305500
Cellular Component	GO:0005654	nucleoplasm	SPIRE1	IDA		Human	GO_REF:0000052
Biological Process	GO:0030036	actin cytoskeleton organization	SPIRE1	IMP		Human	PMID:21620703
Biological Process	GO:0030036	actin cytoskeleton organization	Spire1	IMP		Mouse	MGI:MGI:5050782|PMID:21620703
Biological Process	GO:0007015	actin filament organization	Spire1	IMP		Mouse	MGI:MGI:5698602|PMID:26305500
Biological Process	GO:0030041	actin filament polymerization	Spire1	IMP		Mouse	MGI:MGI:5698602|PMID:26305500
Biological Process	GO:0001662	behavioral fear response	Spire1	IMP	MGI:MGI:4310183	Mouse	PMID:24345451
Biological Process	GO:0036089	cleavage furrow formation	Spire1	IMP		Mouse	MGI:MGI:5050782|PMID:21620703
Biological Process	GO:0060996	dendritic spine development	Spire1	IMP	MGI:MGI:4310183	Mouse	PMID:24345451
Biological Process	GO:0051295	establishment of meiotic spindle localization	SPIRE1	IMP		Human	PMID:21620703
Biological Process	GO:0051295	establishment of meiotic spindle localization	Spire1	IMP		Mouse	MGI:MGI:5050782|PMID:21620703
Biological Process	GO:0070649	formin-nucleated actin cable assembly	SPIRE1	IMP		Human	PMID:26287480
Biological Process	GO:0070649	formin-nucleated actin cable assembly	Spire1	IMP		Mouse	MGI:MGI:5050782|PMID:21620703
Biological Process	GO:0048193	Golgi vesicle transport	Spire1	IDA		Mouse	PMID:11747823
Biological Process	GO:0046907	intracellular transport	Spire1	IMP		Mouse	MGI:MGI:5305386|PMID:21983562
Biological Process	GO:0040038	polar body extrusion after meiotic divisions	Spire1	IMP		Mouse	MGI:MGI:5050782|PMID:21620703
Biological Process	GO:2000781	positive regulation of double-strand break repair	SPIRE1	IMP		Human	PMID:26287480
Biological Process	GO:0090141	positive regulation of mitochondrial fission	SPIRE1	IMP		Human	PMID:26305500
Biological Process	GO:0090141	positive regulation of mitochondrial fission	Spire1	IMP		Mouse	MGI:MGI:5698602|PMID:26305500
Biological Process	GO:0016192	vesicle-mediated transport	Spire1	IMP		Mouse	MGI:MGI:5305386|PMID:21983562

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern