Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPN
  • Mouse genes Spn
  • Rat genes MGC112692,Spn,Spnl1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031072	heat shock protein binding	SPN	IPI	UniProtKB:A0A0H3LCC3	Human	PMID:20633027
Molecular Function	GO:0031072	heat shock protein binding	Spn	IPI	UniProtKB:A0A0H3LCC3	Mouse	MGI:MGI:5882877|PMID:20633027
Molecular Function	GO:0030544	Hsp70 protein binding	SPN	IPI	UniProtKB:A0A0H3L5C8	Human	PMID:20633027
Molecular Function	GO:0005515	protein binding	SPN	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPN	IPI	UniProtKB:Q04941	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPN	IPI	UniProtKB:Q3SXY8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPN	IPI	UniProtKB:Q59EV6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPN	IPI	UniProtKB:Q9BQA9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPN	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPN	IPI	UniProtKB:Q9Y282	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Spn	IPI	UniProtKB:P26040	Mouse	MGI:MGI:5317032|PMID:21289089
Molecular Function	GO:0005515	protein binding	Spn	IPI	PR:Q9QZR5	Mouse	PMID:20360400
Molecular Function	GO:0005515	protein binding	Spn	IPI	PR:Q62230	Mouse	PMID:11238599
Molecular Function	GO:0005515	protein binding	Spn	IPI	PR:P26043	Mouse	PMID:12068294
Molecular Function	GO:0005515	protein binding	Spn	IPI	UniProtKB:P26040|UniProtKB:P26041|UniProtKB:P26043	Rat	PMID:9472040|RGD:13506275
Molecular Function	GO:0019904	protein domain specific binding	Spn	IPI	RGD:1553217	Rat	PMID:18614175|RGD:2303981
Cellular Component	GO:0005604	basement membrane	Spn	IDA		Mouse	PMID:7514104
Cellular Component	GO:0009986	cell surface	SPN	IDA		Human	PMID:12354383
Cellular Component	GO:0009986	cell surface	SPN	IDA		Human	PMID:20605918
Cellular Component	GO:0009986	cell surface	Spn	IDA		Rat	PMID:7758131|RGD:2306195
Cellular Component	GO:0009986	cell surface	Spn	IDA		Rat	PMID:9400815|RGD:2306198
Cellular Component	GO:0032154	cleavage furrow	Spn	IDA		Rat	PMID:8421057|RGD:2306196
Cellular Component	GO:0009897	external side of plasma membrane	Spn	IDA		Mouse	PMID:19299737
Cellular Component	GO:0009897	external side of plasma membrane	Spn	IDA		Mouse	PMID:7790813
Cellular Component	GO:0009897	external side of plasma membrane	Spn	IDA		Mouse	PMID:7566153
Cellular Component	GO:0009897	external side of plasma membrane	Spn	IDA		Mouse	PMID:10943842
Cellular Component	GO:0009897	external side of plasma membrane	Spn	IDA		Mouse	PMID:7514104
Cellular Component	GO:0009897	external side of plasma membrane	Spn	IDA		Mouse	PMID:11380685
Cellular Component	GO:0009897	external side of plasma membrane	Spn	IDA		Mouse	PMID:8920854
Cellular Component	GO:0009897	external side of plasma membrane	Spn	IDA		Mouse	PMID:9645617
Cellular Component	GO:0009897	external side of plasma membrane	Spn	IDA		Mouse	PMID:7477353
Cellular Component	GO:0009897	external side of plasma membrane	Spn	IDA		Mouse	PMID:7795661
Cellular Component	GO:0009897	external side of plasma membrane	Spn	IDA		Mouse	PMID:11728336
Cellular Component	GO:0009897	external side of plasma membrane	Spn	IDA		Mouse	PMID:14635057
Cellular Component	GO:0009897	external side of plasma membrane	Spn	IDA		Mouse	PMID:15843532
Cellular Component	GO:0009897	external side of plasma membrane	Spn	IDA		Mouse	PMID:15117976
Cellular Component	GO:0070062	extracellular exosome	SPN	HDA		Human	PMID:20458337
Cellular Component	GO:0005615	extracellular space	SPN	IDA		Human	PMID:10899905
Cellular Component	GO:0016020	membrane	SPN	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Spn	IDA		Rat	PMID:10233680|RGD:2306197
Cellular Component	GO:0005902	microvillus	Spn	IDA		Rat	PMID:8421057|RGD:2306196
Cellular Component	GO:0005902	microvillus	Spn	IDA		Rat	PMID:9472040|RGD:13506275
Cellular Component	GO:0005886	plasma membrane	Spn	IDA		Mouse	PMID:11728336
Cellular Component	GO:0005886	plasma membrane	Spn	IDA		Mouse	PMID:11937524
Cellular Component	GO:0001931	uropod	Spn	IDA		Mouse	MGI:MGI:6242696|PMID:24250818
Cellular Component	GO:0001931	uropod	Spn	IDA		Mouse	MGI:MGI:5317032|PMID:21289089
Cellular Component	GO:0001931	uropod	Spn	IDA		Mouse	PMID:11937524
Cellular Component	GO:0001931	uropod	Spn	IDA		Mouse	PMID:11728336
Biological Process	GO:0097190	apoptotic signaling pathway	Spn	IDA		Mouse	PMID:10429671
Biological Process	GO:0007166	cell surface receptor signaling pathway	Spn	IDA		Mouse	PMID:7790813
Biological Process	GO:0002544	chronic inflammatory response	Spn	IEP		Rat	PMID:10486239|RGD:2303982
Biological Process	GO:0042742	defense response to bacterium	SPN	IDA		Human	PMID:10899905
Biological Process	GO:0042742	defense response to bacterium	Spn	IMP	MGI:MGI:1857246	Mouse	PMID:10899905
Biological Process	GO:0050901	leukocyte tethering or rolling	Spn	IMP		Mouse	MGI:MGI:6114858|PMID:26700769
Biological Process	GO:0042117	monocyte activation	Spn	IEP		Rat	PMID:9400815|RGD:2306198
Biological Process	GO:0007162	negative regulation of cell adhesion	Spn	IDA		Mouse	PMID:11937524
Biological Process	GO:0007162	negative regulation of cell adhesion	Spn	IMP	MGI:MGI:1857246	Mouse	PMID:11828253
Biological Process	GO:0007162	negative regulation of cell adhesion	Spn	IMP	MGI:MGI:1857246	Mouse	PMID:7566153
Biological Process	GO:0050868	negative regulation of T cell activation	Spn	IMP	MGI:MGI:1857246	Mouse	PMID:9645617
Biological Process	GO:0042130	negative regulation of T cell proliferation	Spn	IMP		Mouse	MGI:MGI:3847636|PMID:17638845
Biological Process	GO:0042130	negative regulation of T cell proliferation	Spn	IMP	MGI:MGI:1857246	Mouse	PMID:15117976
Biological Process	GO:0042130	negative regulation of T cell proliferation	Spn	IMP	MGI:MGI:1857246	Mouse	PMID:7566153
Biological Process	GO:0042130	negative regulation of T cell proliferation	Spn	IMP	MGI:MGI:1857246	Mouse	PMID:9645617
Biological Process	GO:0001808	negative regulation of type IV hypersensitivity	Spn	IMP	MGI:MGI:1857246	Mouse	PMID:9645617
Biological Process	GO:0045060	negative thymic T cell selection	Spn	IMP	MGI:MGI:1857246	Mouse	PMID:10429671
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Spn	IGI	MGI:MGI:1314872	Mouse	PMID:20360400
Biological Process	GO:2000406	positive regulation of T cell migration	Spn	IMP		Mouse	MGI:MGI:3847636|PMID:17638845
Biological Process	GO:0042102	positive regulation of T cell proliferation	Spn	IDA		Mouse	PMID:11380685
Biological Process	GO:0042102	positive regulation of T cell proliferation	Spn	IDA		Mouse	PMID:7790813
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	SPN	IDA		Human	PMID:10899905
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Spn	IMP	MGI:MGI:1857246	Mouse	PMID:10899905
Biological Process	GO:0006468	protein phosphorylation	Spn	IGI	MGI:MGI:1314872	Mouse	PMID:20360400
Biological Process	GO:0050688	regulation of defense response to virus	Spn	IMP	MGI:MGI:1857246	Mouse	PMID:7566153
Biological Process	GO:0010468	regulation of gene expression	Spn	IGI	UniProtKB:P06800	Rat	PMID:12496963|RGD:1358565
Biological Process	GO:0050776	regulation of immune response	Spn	IMP	MGI:MGI:1857246	Mouse	PMID:7566153
Biological Process	GO:0050776	regulation of immune response	Spn	IMP	MGI:MGI:1857246	Mouse	PMID:9645617
Biological Process	GO:2000404	regulation of T cell migration	Spn	IMP		Mouse	MGI:MGI:5317032|PMID:21289089
Biological Process	GO:0001562	response to protozoan	Spn	IDA		Mouse	PMID:11994475
Biological Process	GO:0031295	T cell costimulation	Spn	IDA		Mouse	PMID:11380685
Biological Process	GO:0031295	T cell costimulation	Spn	IDA		Mouse	PMID:7790813
Biological Process	GO:0031295	T cell costimulation	Spn	IDA		Mouse	PMID:10429671
Biological Process	GO:0042098	T cell proliferation	Spn	IDA		Mouse	PMID:11380685
Biological Process	GO:0050852	T cell receptor signaling pathway	Spn	IGI	UniProtKB:P06800	Rat	PMID:12496963|RGD:1358565
Biological Process	GO:0002296	T-helper 1 cell lineage commitment	SPN	IDA		Human	PMID:18036228
Biological Process	GO:0071594	thymocyte aggregation	Spn	IMP		Rat	PMID:1382990|RGD:2306194

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern