Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPNS2
  • Mouse genes Spns2
  • Rat genes Spns2
  • Zfish genes spns2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spns2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0046624	sphingolipid transporter activity	SPNS2	IDA		Human	PMID:21084291
Molecular Function	GO:0046624	sphingolipid transporter activity	Spns2	IDA		Mouse	MGI:MGI:6695640|PMID:33785361
Molecular Function	GO:0046624	sphingolipid transporter activity	Spns2	IDA		Mouse	MGI:MGI:5487752|PMID:23103166
Molecular Function	GO:0046624	sphingolipid transporter activity	Spns2	IDA		Mouse	MGI:MGI:6865808|PMID:34260944
Biological Process	GO:0001782	B cell homeostasis	Spns2	IMP	MGI:MGI:5426392	Mouse	PMID:22406534
Biological Process	GO:0001782	B cell homeostasis	Spns2	IMP	MGI:MGI:4460276	Mouse	PMID:22664872
Biological Process	GO:0001782	B cell homeostasis	Spns2	IMP	MGI:MGI:5442804	Mouse	PMID:22664872
Biological Process	GO:0060348	bone development	Spns2	IMP		Mouse	PMID:22876197
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	spns2	IDA		Zfish	PMID:19074308
Biological Process	GO:0003319	cardioblast migration to the midline involved in heart rudiment formation	spns2	IMP	ZFIN:ZDB-GENO-090423-2	Zfish	PMID:23951404
Biological Process	GO:0003319	cardioblast migration to the midline involved in heart rudiment formation	spns2	IGI	ZFIN:ZDB-GENO-131017-1	Zfish	PMID:23951404
Biological Process	GO:0003143	embryonic heart tube morphogenesis	spns2	IMP	ZFIN:ZDB-MRPHLNO-090423-1	Zfish	PMID:24451492
Biological Process	GO:0003143	embryonic heart tube morphogenesis	spns2	IGI	ZFIN:ZDB-GENE-040426-1156,ZFIN:ZDB-MRPHLNO-090423-1	Zfish	PMID:24451492
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	spns2	IGI	ZFIN:ZDB-GENO-131017-1	Zfish	PMID:23951404
Biological Process	GO:0006869	lipid transport	SPNS2	IDA		Human	PMID:21084291
Biological Process	GO:0048535	lymph node development	Spns2	IMP	MGI:MGI:4460276	Mouse	PMID:23180825
Biological Process	GO:0002260	lymphocyte homeostasis	Spns2	IMP	MGI:MGI:4460276	Mouse	PMID:23180825
Biological Process	GO:0072676	lymphocyte migration	Spns2	IMP	MGI:MGI:5426395	Mouse	PMID:22406534
Biological Process	GO:0072676	lymphocyte migration	Spns2	IMP	MGI:MGI:5426392	Mouse	PMID:22406534
Biological Process	GO:0061035	regulation of cartilage development	spns2	IMP	ZFIN:ZDB-GENO-120221-11	Zfish	PMID:22185793
Biological Process	GO:0048073	regulation of eye pigmentation	Spns2	IMP	MGI:MGI:4460276	Mouse	PMID:22664872
Biological Process	GO:0002920	regulation of humoral immune response	Spns2	IDA		Mouse	MGI:MGI:6865808|PMID:34260944
Biological Process	GO:0002920	regulation of humoral immune response	Spns2	IMP	MGI:MGI:4460276	Mouse	PMID:22664872
Biological Process	GO:2000404	regulation of T cell migration	Spns2	IDA		Mouse	MGI:MGI:6865808|PMID:34260944
Biological Process	GO:0007605	sensory perception of sound	Spns2	IMP		Mouse	MGI:MGI:5749360|PMID:25356849
Biological Process	GO:0006665	sphingolipid metabolic process	Spns2	IMP	MGI:MGI:4460276	Mouse	PMID:23180825
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	Spns2	IDA		Mouse	MGI:MGI:5487752|PMID:23103166
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	Spns2	IDA		Mouse	MGI:MGI:6865808|PMID:34260944
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	Spns2	IDA		Mouse	MGI:MGI:6695640|PMID:33785361
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	Spns2	IMP	MGI:MGI:5426395	Mouse	PMID:22406534
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	Spns2	IMP	MGI:MGI:4460276	Mouse	PMID:23180825
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	spns2	IMP	ZFIN:ZDB-GENO-120221-11	Zfish	PMID:22185793
Biological Process	GO:0043029	T cell homeostasis	Spns2	IMP	MGI:MGI:5442804	Mouse	PMID:22664872
Biological Process	GO:0043029	T cell homeostasis	Spns2	IMP	MGI:MGI:4460276	Mouse	PMID:22664872
Biological Process	GO:0043029	T cell homeostasis	Spns2	IMP	MGI:MGI:5426392	Mouse	PMID:22406534
Biological Process	GO:0001944	vasculature development	spns2	IGI	ZFIN:ZDB-MRPHLNO-090423-1,ZFIN:ZDB-MRPHLNO-121026-2	Zfish	PMID:23229546

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern