Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPOCK1
  • Mouse genes Spock1
  • Rat genes Spock1
  • Zfish genes spock1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spock1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	SPOCK1	IDA		Human	PMID:9323035
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity	SPOCK1	IDA		Human	PMID:14511383
Molecular Function	GO:0008191	metalloendopeptidase inhibitor activity	SPOCK1	IDA		Human	PMID:11751414
Molecular Function	GO:0005515	protein binding	SPOCK1	IPI	UniProtKB:Q96BA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPOCK1	IPI	UniProtKB:Q9BXK5	Human	PMID:32296183
Cellular Component	GO:0005737	cytoplasm	Spock1	IDA		Mouse	MGI:MGI:2667547|PMID:10842087
Cellular Component	GO:0005615	extracellular space	SPOCK1	IDA		Human	PMID:14511383
Cellular Component	GO:0031594	neuromuscular junction	Spock1	IDA		Mouse	MGI:MGI:2667547|PMID:10842087
Cellular Component	GO:0033268	node of Ranvier	Spock1	IDA		Mouse	MGI:MGI:2667547|PMID:10842087
Cellular Component	GO:0016528	sarcoplasm	Spock1	IDA		Mouse	MGI:MGI:2667547|PMID:10842087
Biological Process	GO:0021953	central nervous system neuron differentiation	Spock1	IEP		Mouse	MGI:MGI:1353269|PMID:10640720
Biological Process	GO:0010812	negative regulation of cell-substrate adhesion	SPOCK1	IDA		Human	PMID:12853036
Biological Process	GO:0010951	negative regulation of endopeptidase activity	SPOCK1	IDA		Human	PMID:14511383
Biological Process	GO:0010977	negative regulation of neuron projection development	SPOCK1	IDA		Human	PMID:12853036
Biological Process	GO:0022008	neurogenesis	Spock1	IEP		Mouse	MGI:MGI:1353269|PMID:10640720
Biological Process	GO:0001764	neuron migration	Spock1	IEP		Mouse	MGI:MGI:1353269|PMID:10640720

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern