Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPOP
  • Mouse genes Spop
  • Rat genes Spop
  • Zfish genes spop
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spop

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140678	molecular function inhibitor activity	SPOP	EXP		Human	PMID:31624231
Molecular Function	GO:0005515	protein binding	SPOP	IPI	UniProtKB:Q99836	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SPOP	IPI	UniProtKB:Q9UER7	Human	PMID:21573799
Molecular Function	GO:0005515	protein binding	SPOP	IPI	UniProtKB:Q13618	Human	PMID:21577200
Molecular Function	GO:0005515	protein binding	SPOP	IPI	UniProtKB:Q9Y6Q9	Human	PMID:21577200
Molecular Function	GO:0005515	protein binding	SPOP	IPI	UniProtKB:Q13618	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SPOP	IPI	UniProtKB:Q99836	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SPOP	IPI	UniProtKB:Q9UER7	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SPOP	IPI	UniProtKB:P60484	Human	PMID:24656772
Molecular Function	GO:0005515	protein binding	SPOP	IPI	UniProtKB:Q16829	Human	PMID:24656772
Molecular Function	GO:0005515	protein binding	SPOP	IPI	UniProtKB:Q99836	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Spop	IPI	UniProtKB:P10071|UniProtKB:Q0VGT2	Mouse	MGI:MGI:6093025|PMID:19955409
Molecular Function	GO:0005515	protein binding	Spop	IPI	UniProtKB:P52946	Mouse	MGI:MGI:5512841|PMID:17126328
Molecular Function	GO:0005515	protein binding	Spop	IPI	PR:P52946	Mouse	PMID:15121856
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Spop	IPI	PR:Q0VGT2	Mouse	PMID:19684112
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Spop	IPI	PR:Q61602	Mouse	PMID:19684112
Molecular Function	GO:0031625	ubiquitin protein ligase binding	SPOP	IPI	UniProtKB:Q13077	Human	PMID:11279055
Molecular Function	GO:0031625	ubiquitin protein ligase binding	SPOP	IPI	UniProtKB:Q9Y4K3	Human	PMID:11279055
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	SPOP	IDA		Human	PMID:14528312
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	SPOP	IDA		Human	PMID:22085717
Cellular Component	GO:0016607	nuclear speck	Spop	IDA		Mouse	PMID:15121856
Cellular Component	GO:0016607	nuclear speck	Spop	IDA		Mouse	PMID:19684112
Cellular Component	GO:0005634	nucleus	SPOP	IDA		Human	PMID:22085717
Biological Process	GO:0042593	glucose homeostasis	Spop	IGI	MGI:MGI:102851	Mouse	PMID:20679732
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Spop	IGI	MGI:MGI:102851	Mouse	PMID:20811152
Biological Process	GO:0051179	localization	SPOP	IDA		Human	PMID:31624231
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Spop	IDA		Mouse	PMID:15121856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Spop	IDA		Mouse	PMID:15121856
Biological Process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Spop	IGI	MGI:MGI:102851	Mouse	PMID:20811152
Biological Process	GO:2000676	positive regulation of type B pancreatic cell apoptotic process	Spop	IGI	MGI:MGI:102851	Mouse	PMID:20679732
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	SPOP	IMP		Human	PMID:22085717
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	SPOP	IMP		Human	PMID:32109420
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Spop	IGI	MGI:MGI:1347360	Mouse	PMID:20811152
Biological Process	GO:0000209	protein polyubiquitination	SPOP	IDA		Human	PMID:14528312
Biological Process	GO:0097050	type B pancreatic cell apoptotic process	Spop	IGI	MGI:MGI:102851	Mouse	PMID:20679732
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Spop	IDA		Mouse	PMID:19684112

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern