Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPP1
  • Mouse genes Spp1
  • Rat genes Spp1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050840	extracellular matrix binding	Spp1	IDA		Mouse	PMID:18757743
Molecular Function	GO:0005178	integrin binding	SPP1	IPI	ComplexPortal:CPX-1827	Human	PMID:25839998
Molecular Function	GO:0043167	ion binding	SPP1	IPI	ChEBI:29108	Human	PMID:24928493
Molecular Function	GO:0043167	ion binding	SPP1	EXP		Human	PMID:33914399
Molecular Function	GO:0005515	protein binding	SPP1	IPI	UniProtKB:P05106,UniProtKB:P08648	Human	PMID:10747989
Molecular Function	GO:0005515	protein binding	SPP1	IPI	UniProtKB:P16070	Human	PMID:10747989
Molecular Function	GO:0005515	protein binding	SPP1	IPI	UniProtKB:P08603	Human	PMID:11162539
Molecular Function	GO:0005515	protein binding	SPP1	IPI	UniProtKB:O43765	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SPP1	IPI	UniProtKB:O43765	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SPP1	IPI	UniProtKB:Q8IXL6	Human	PMID:22582013
Molecular Function	GO:0005515	protein binding	SPP1	IPI	UniProtKB:O43765	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPP1	IPI	UniProtKB:P50222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPP1	IPI	UniProtKB:O43765	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	SPP1	IPI	UniProtKB:Q8IXL6	Human	PMID:26091039
Molecular Function	GO:0005515	protein binding	SPP1	IPI	UniProtKB:O43681	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPP1	IPI	UniProtKB:P62166	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPP1	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPP1	IPI	UniProtKB:P46379-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPP1	IPI	UniProtKB:P16070	Human	PMID:8560266
Molecular Function	GO:0036094	small molecule binding	SPP1	EXP		Human	PMID:33914399
Cellular Component	GO:0045177	apical part of cell	Spp1	IDA		Mouse	PMID:16518820
Cellular Component	GO:0042995	cell projection	Spp1	IDA		Rat	PMID:12162503|RGD:730240
Cellular Component	GO:0005737	cytoplasm	Spp1	IDA		Mouse	PMID:16518820
Cellular Component	GO:0070062	extracellular exosome	SPP1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	SPP1	IDA		Human	PMID:15516325
Cellular Component	GO:0005615	extracellular space	SPP1	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	Spp1	IDA		Rat	PMID:18758911|RGD:2301841
Cellular Component	GO:0005794	Golgi apparatus	SPP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Spp1	IDA		Rat	PMID:12162503|RGD:730240
Cellular Component	GO:0031982	vesicle	Spp1	IDA		Rat	PMID:18758911|RGD:2301841
Biological Process	GO:0006710	androgen catabolic process	SPP1	IDA		Human	PMID:26482249
Biological Process	GO:0030282	bone mineralization	Spp1	IMP	MGI:MGI:2385534	Mouse	PMID:12817751
Biological Process	GO:0030282	bone mineralization	Spp1	IMP	MGI:MGI:1856651	Mouse	PMID:12817751
Biological Process	GO:0030282	bone mineralization	Spp1	IDA		Mouse	PMID:12817751
Biological Process	GO:0055074	calcium ion homeostasis	Spp1	IDA		Mouse	PMID:12817751
Biological Process	GO:0007155	cell adhesion	SPP1	IDA		Human	PMID:25839998
Biological Process	GO:0007155	cell adhesion	Spp1	IDA		Rat	PMID:11792563|RGD:1581129
Biological Process	GO:0007155	cell adhesion	Spp1	IMP		Rat	PMID:3024151|RGD:70021
Biological Process	GO:0030154	cell differentiation	Spp1	IEP		Rat	PMID:16618210|RGD:1581120
Biological Process	GO:0071498	cellular response to fluid shear stress	Spp1	IDA		Mouse	PMID:24841674
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Spp1	IEP		Mouse	PMID:20439489
Biological Process	GO:0071394	cellular response to testosterone stimulus	SPP1	IDA		Human	PMID:26482249
Biological Process	GO:0072044	collecting duct development	Spp1	IMP		Mouse	PMID:17898038
Biological Process	GO:0006954	inflammatory response	Spp1	IEP		Rat	PMID:16679731|RGD:1581118
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Spp1	IMP		Mouse	PMID:17898038
Biological Process	GO:0030644	intracellular chloride ion homeostasis	Spp1	IMP		Mouse	PMID:17898038
Biological Process	GO:0030643	intracellular phosphate ion homeostasis	Spp1	IMP		Mouse	PMID:17898038
Biological Process	GO:0006883	intracellular sodium ion homeostasis	Spp1	IMP		Mouse	PMID:17898038
Biological Process	GO:0048685	negative regulation of collateral sprouting of intact axon in response to injury	Spp1	IEP		Rat	PMID:15625076|RGD:1581125
Biological Process	GO:0030593	neutrophil chemotaxis	Spp1	IDA		Mouse	PMID:21321126
Biological Process	GO:0030593	neutrophil chemotaxis	Spp1	IGI	MGI:MGI:104756	Mouse	PMID:21321126
Biological Process	GO:0001649	osteoblast differentiation	Spp1	IMP		Rat	PMID:15598896|RGD:1581126
Biological Process	GO:0045780	positive regulation of bone resorption	Spp1	IDA		Rat	PMID:11792563|RGD:1581129
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	Spp1	IDA		Mouse	PMID:18757743
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	SPP1	IDA		Human	PMID:26482249
Biological Process	GO:2000866	positive regulation of estradiol secretion	SPP1	IDA		Human	PMID:26482249
Biological Process	GO:0036005	response to macrophage colony-stimulating factor	Spp1	IEP		Rat	PMID:7669437|RGD:151665777
Biological Process	GO:0010033	response to organic substance	Spp1	IDA		Rat	PMID:16414014|RGD:1581121
Biological Process	GO:0048545	response to steroid hormone	Spp1	IDA		Rat	PMID:11250650|RGD:1581127
Biological Process	GO:0033280	response to vitamin D	SPP1	IDA		Human	PMID:16720713
Biological Process	GO:0034418	urate biosynthetic process	Spp1	IMP		Mouse	PMID:17898038

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern