Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPPL2A
  • Mouse genes Sppl2a
  • Rat genes Sppl2a
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sppl2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	SPPL2A	IDA		Human	PMID:2313285
Molecular Function	GO:0005515	protein binding	SPPL2A	IPI	UniProtKB:O43765	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SPPL2A	IPI	UniProtKB:Q9Y287	Human	PMID:17965014
Molecular Function	GO:0005515	protein binding	SPPL2A	IPI	UniProtKB:O43765	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPPL2A	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPPL2A	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0042803	protein homodimerization activity	SPPL2A	IDA		Human	PMID:15385547
Cellular Component	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	SPPL2A	IDA		Human	PMID:15385547
Cellular Component	GO:0070062	extracellular exosome	SPPL2A	HDA		Human	PMID:23533145
Cellular Component	GO:0030660	Golgi-associated vesicle membrane	SPPL2A	IDA		Human	PMID:17965014
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	SPPL2A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005770	late endosome	SPPL2A	IDA		Human	PMID:16829952
Cellular Component	GO:0031902	late endosome membrane	Sppl2a	IDA		Mouse	PMID:21896273
Cellular Component	GO:0098553	lumenal side of endoplasmic reticulum membrane	SPPL2A	IDA		Human	PMID:15385547
Cellular Component	GO:0005765	lysosomal membrane	SPPL2A	HDA		Human	PMID:17897319
Cellular Component	GO:0005765	lysosomal membrane	Sppl2a	IDA		Mouse	PMID:21896273
Cellular Component	GO:0016020	membrane	SPPL2A	IDA		Human	PMID:2313285
Cellular Component	GO:0005886	plasma membrane	SPPL2A	IDA		Human	GO_REF:0000052
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	SPPL2A	IDA		Human	PMID:16829951
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	SPPL2A	IDA		Human	PMID:17965014
Biological Process	GO:0031293	membrane protein intracellular domain proteolysis	SPPL2A	IDA		Human	PMID:16829951
Biological Process	GO:0031293	membrane protein intracellular domain proteolysis	SPPL2A	IMP		Human	PMID:16829952
Biological Process	GO:0031293	membrane protein intracellular domain proteolysis	SPPL2A	IDA		Human	PMID:17557115
Biological Process	GO:0033619	membrane protein proteolysis	SPPL2A	IDA		Human	PMID:2313285
Biological Process	GO:0033619	membrane protein proteolysis	Sppl2a	IMP		Mouse	MGI:MGI:6718040|PMID:33239420
Biological Process	GO:0050776	regulation of immune response	SPPL2A	IMP		Human	PMID:16829952
Biological Process	GO:0050776	regulation of immune response	Sppl2a	IMP		Mouse	MGI:MGI:6381158|PMID:30127434
Biological Process	GO:0050776	regulation of immune response	Sppl2a	IMP		Mouse	MGI:MGI:6718040|PMID:33239420

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern