Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPPL3
  • Mouse genes Sppl3
  • Rat genes Sppl3
  • Zfish genes sppl3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sppl3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	SPPL3	IMP		Human	PMID:16873890
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	SPPL3	IDA		Human	PMID:2313285
Molecular Function	GO:0005515	protein binding	SPPL3	IPI	UniProtKB:Q87041	Human	PMID:2313285
Molecular Function	GO:0005515	protein binding	Sppl3	IPI	UniProtKB:Q13586	Mouse	MGI:MGI:5640905|PMID:25384971
Molecular Function	GO:0042803	protein homodimerization activity	SPPL3	IDA		Human	PMID:15385547
Molecular Function	GO:0042803	protein homodimerization activity	SPPL3	IDA		Human	PMID:15998642
Molecular Function	GO:0042803	protein homodimerization activity	SPPL3	IDA		Human	PMID:16873890
Cellular Component	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	SPPL3	IDA		Human	PMID:15385547
Cellular Component	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	Sppl3	IDA		Mouse	MGI:MGI:5640905|PMID:25384971
Cellular Component	GO:0030660	Golgi-associated vesicle membrane	SPPL3	IDA		Human	PMID:16829952
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	SPPL3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0098553	lumenal side of endoplasmic reticulum membrane	SPPL3	IDA		Human	PMID:15385547
Cellular Component	GO:0016020	membrane	SPPL3	IDA		Human	PMID:2313285
Cellular Component	GO:0005886	plasma membrane	SPPL3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005791	rough endoplasmic reticulum	SPPL3	IDA		Human	PMID:15998642
Biological Process	GO:0033619	membrane protein proteolysis	SPPL3	IDA		Human	PMID:2313285
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	SPPL3	IMP		Human	PMID:25384971
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	Sppl3	IDA		Mouse	MGI:MGI:5640905|PMID:25384971
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Sppl3	IDA		Mouse	MGI:MGI:5640905|PMID:25384971
Biological Process	GO:0032092	positive regulation of protein binding	Sppl3	IDA		Mouse	MGI:MGI:5640905|PMID:25384971
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	SPPL3	IMP		Human	PMID:25384971
Biological Process	GO:0043523	regulation of neuron apoptotic process	sppl3	IMP		Zfish	PMID:15998642
Biological Process	GO:0050852	T cell receptor signaling pathway	SPPL3	IMP		Human	PMID:25384971
Biological Process	GO:0050852	T cell receptor signaling pathway	Sppl3	IDA		Mouse	MGI:MGI:5640905|PMID:25384971

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern