Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPRED2
  • Mouse genes Spred2
  • Rat genes Spred2
  • Zfish genes spred2a,spred2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spred2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q14596	Human	PMID:19822672
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q8IUH5	Human	PMID:24705354
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:O95985	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q9NZD8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P51812	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:O95985	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q9NZD8	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:A0A024R8L2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:O14633	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P15622-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P17568	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P29972	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P47897	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P59991	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P62166	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P62760	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q5RL73	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q5T749	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q5T751	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q5TCM9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q86XF7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q8TAU3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q96EG3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q96IQ9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q99598	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q99750	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q9BYR9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q9NZD8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q9NZI2-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q9UK32	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:G5E9A7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:O60333-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P02545	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P14136	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P19404	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P27797	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P28329-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P28799	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P29474	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P36957	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P50570-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P51812	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P60891	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q53GS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q8TDX7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q92870-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:Q9Y3C5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRED2	IPI	UniProtKB:P21359	Human	PMID:34626534
Molecular Function	GO:0005515	protein binding	Spred2	IPI	UniProtKB:Q14596	Mouse	MGI:MGI:4366363|PMID:19822672
Molecular Function	GO:0005515	protein binding	Spred2	IPI	UniProtKB:Q63572	Mouse	MGI:MGI:3771987|PMID:17974561
Molecular Function	GO:0005515	protein binding	Spred2	IPI	PR:P05532	Mouse	PMID:12646235
Molecular Function	GO:0019901	protein kinase binding	SPRED2	IPI	UniProtKB:Q13627	Human	PMID:20736167
Molecular Function	GO:0019901	protein kinase binding	Spred2	IPI	UniProtKB:Q61214	Mouse	MGI:MGI:5318016|PMID:20736167
Molecular Function	GO:0030291	protein serine/threonine kinase inhibitor activity	Spred2	IDA		Mouse	MGI:MGI:5318016|PMID:20736167
Molecular Function	GO:0005173	stem cell factor receptor binding	Spred2	IPI	PR:P05532	Mouse	PMID:12646235
Cellular Component	GO:0031410	cytoplasmic vesicle	Spred2	IDA		Mouse	PMID:15580519
Cellular Component	GO:0005886	plasma membrane	Spred2	IDA		Mouse	PMID:12646235
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	Spred2	IDA		Mouse	MGI:MGI:6414689|PMID:25576668
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Spred2	IDA		Mouse	MGI:MGI:6414698|PMID:29501879
Biological Process	GO:1902747	negative regulation of lens fiber cell differentiation	Spred2	IDA		Mouse	MGI:MGI:6414698|PMID:29501879
Biological Process	GO:0043409	negative regulation of MAPK cascade	Spred2	IMP		Mouse	PMID:12646235
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	SPRED2	IMP		Human	PMID:20736167
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	Spred2	IDA		Mouse	MGI:MGI:5318016|PMID:20736167
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Spred2	IDA		Mouse	MGI:MGI:6414689|PMID:25576668
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	Spred2	IDA		Mouse	MGI:MGI:5318016|PMID:20736167
Biological Process	GO:0090311	regulation of protein deacetylation	Spred2	IDA		Mouse	MGI:MGI:5318016|PMID:20736167

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern