Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Spry2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SPRY2
- Mouse genes Spry2
- Rat genes Spry2
- Zfish genes spry2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spry2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P22681	Human	PMID:12815057
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P22681	Human	PMID:15962011
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q96B97	Human	PMID:15962011
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q9BQ66	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P49817	Human	PMID:16877379
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P22681	Human	PMID:16893902
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P62993	Human	PMID:16893902
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P22681	Human	PMID:17974561
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P30153	Human	PMID:17974561
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P62993	Human	PMID:17974561
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P67775	Human	PMID:17974561
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q63572	Human	PMID:17974561
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P22681	Human	PMID:18273061
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P32242	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P57075	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P26651	Human	PMID:21784977
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:O43741	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:O43559	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:O43609	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:O43639	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:O43741	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:O60336	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:O60573	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:O75716	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:O75791	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P14770	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P26371	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P29972	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P32242	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P43115-12	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P50222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P57075	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P60370	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P60410	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P60411	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P60412	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q02930-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q06455-4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q14847	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q17RB8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q5JPT6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q5T5A8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q5T5B0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q5T7P3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q5TA78	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q5TA82	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q6L8G9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q6P2C6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q86UY0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q8IUH5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q8NEC5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q8TAU3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q8TF42	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q8WXE1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q96MH2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q96SQ5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q99750	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q9BQ66	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q9BYQ2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q9BYQ4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q9BYQ6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q9BYR0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q9H2F3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q9H2X0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q9NUL5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q9NVQ4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q9UJV3-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q9UKS6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q9Y223	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q9Y2K6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q9Y4C2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P07510-2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:P28799	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q8N6R0	Human	PMID:29408807
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q5T7P3	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	SPRY2	IPI	UniProtKB:Q5T7P3	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	Spry2	IPI	UniProtKB:P49817\|UniProtKB:Q9QXV9	Mouse	MGI:MGI:3695236\|PMID:16877379
Molecular Function	GO:0005515	protein binding	Spry2	IPI	MGI:MGI:1345188	Mouse	PMID:16339969
Molecular Function	GO:0005515	protein binding	Spry2	IPI	PR:Q9QXV9	Mouse	PMID:16339969
Molecular Function	GO:0005515	protein binding	Spry2	IPI	PR:Q9QXV8	Mouse	PMID:16339969
Molecular Function	GO:0005515	protein binding	Spry2	IPI	PR:Q60631	Mouse	PMID:11585837
Molecular Function	GO:0005515	protein binding	Spry2	IPI	PR:Q9WTP2	Mouse	PMID:16339969
Molecular Function	GO:0019901	protein kinase binding	SPRY2	IPI	UniProtKB:Q61214	Human	PMID:20736167
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	SPRY2	IMP		Human	PMID:18070883
Cellular Component	GO:0015629	actin cytoskeleton	SPRY2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005856	cytoskeleton	Spry2	IDA		Mouse	MGI:MGI:5693366\|PMID:18508928
Cellular Component	GO:0005829	cytosol	Spry2	IDA		Mouse	MGI:MGI:5693366\|PMID:18508928
Cellular Component	GO:0016020	membrane	Spry2	IDA		Mouse	MGI:MGI:5693366\|PMID:18508928
Cellular Component	GO:0015630	microtubule cytoskeleton	SPRY2	IDA		Human	GO_REF:0000052
Cellular Component	GO:1990752	microtubule end	SPRY2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Spry2	IDA		Mouse	MGI:MGI:5693366\|PMID:18508928
Biological Process	GO:0001525	angiogenesis	spry2	IMP	ZFIN:ZDB-MRPHLNO-110107-3	Zfish	PMID:22207734
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	Spry2	IMP		Mouse	PMID:10074434
Biological Process	GO:0060449	bud elongation involved in lung branching	Spry2	IGI	MGI:MGI:1099809	Mouse	PMID:21764747
Biological Process	GO:0060449	bud elongation involved in lung branching	Spry2	IGI	MGI:MGI:1345139	Mouse	PMID:21764747
Biological Process	GO:0045165	cell fate commitment	Spry2	IMP	MGI:MGI:3578633	Mouse	PMID:15809037
Biological Process	GO:0045165	cell fate commitment	Spry2	IGI	MGI:MGI:99604	Mouse	PMID:15809037
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Spry2	IEP		Mouse	PMID:20439489
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	SPRY2	IDA		Human	PMID:21536891
Biological Process	GO:0009953	dorsal/ventral pattern formation	spry2	IMP		Zfish	PMID:15151985
Biological Process	GO:0009953	dorsal/ventral pattern formation	spry2	IGI	ZFIN:ZDB-GENE-990415-72	Zfish	PMID:15151985
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Spry2	IGI	MGI:MGI:1099809	Mouse	PMID:21764747
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Spry2	IGI	MGI:MGI:1345139	Mouse	PMID:21764747
Biological Process	GO:0000132	establishment of mitotic spindle orientation	Spry2	IGI	MGI:MGI:1099809	Mouse	PMID:21764747
Biological Process	GO:0000132	establishment of mitotic spindle orientation	Spry2	IGI	MGI:MGI:1345139	Mouse	PMID:21764747
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Spry2	IGI	MGI:MGI:99604	Mouse	PMID:15809037
Biological Process	GO:0042472	inner ear morphogenesis	Spry2	IGI	MGI:MGI:99604	Mouse	PMID:15809037
Biological Process	GO:0042472	inner ear morphogenesis	Spry2	IMP	MGI:MGI:3578633	Mouse	PMID:15809037
Biological Process	GO:0030324	lung development	Spry2	IMP		Mouse	PMID:10074434
Biological Process	GO:0060437	lung growth	Spry2	IDA		Mouse	PMID:11287183
Biological Process	GO:0060425	lung morphogenesis	Spry2	IDA		Mouse	PMID:11287183
Biological Process	GO:0016525	negative regulation of angiogenesis	SPRY2	IMP		Human	PMID:24177325
Biological Process	GO:0043066	negative regulation of apoptotic process	SPRY2	IMP		Human	PMID:18070883
Biological Process	GO:0043066	negative regulation of apoptotic process	Spry2	IMP		Mouse	MGI:MGI:3773987\|PMID:18070883
Biological Process	GO:0008285	negative regulation of cell population proliferation	Spry2	IDA		Mouse	PMID:11585837
Biological Process	GO:0031345	negative regulation of cell projection organization	Spry2	IDA		Mouse	MGI:MGI:5693366\|PMID:18508928
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	Spry2	IDA		Mouse	MGI:MGI:6414689\|PMID:25576668
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	SPRY2	IMP		Human	PMID:20489163
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	SPRY2	IDA		Human	PMID:21536891
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Spry2	IDA		Mouse	MGI:MGI:6414698\|PMID:29501879
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Spry2	IDA		Mouse	MGI:MGI:5693366\|PMID:18508928
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Spry2	IGI	MGI:MGI:1099809	Mouse	PMID:21764747
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Spry2	IDA		Mouse	PMID:11585837
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Spry2	IGI	MGI:MGI:1345139	Mouse	PMID:21764747
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	Spry2	IGI	MGI:MGI:99604	Mouse	PMID:15809037
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	Spry2	IDA		Mouse	PMID:11585837
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	spry2	IGI	ZFIN:ZDB-GENE-990415-72	Zfish	PMID:15151985
Biological Process	GO:0034260	negative regulation of GTPase activity	Spry2	IDA		Mouse	PMID:11585837
Biological Process	GO:1902747	negative regulation of lens fiber cell differentiation	Spry2	IDA		Mouse	MGI:MGI:6414698\|PMID:29501879
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Spry2	IDA		Mouse	PMID:16339969
Biological Process	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway	Spry2	IDA		Mouse	PMID:11585837
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	SPRY2	IDA		Human	PMID:20736167
Biological Process	GO:0031397	negative regulation of protein ubiquitination	SPRY2	IDA		Human	PMID:17974561
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	Spry2	IDA		Mouse	PMID:11585837
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Spry2	IDA		Mouse	MGI:MGI:6414689\|PMID:25576668
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	SPRY2	IDA		Human	PMID:21536891
Biological Process	GO:0030335	positive regulation of cell migration	SPRY2	IMP		Human	PMID:20489163
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	SPRY2	IMP		Human	PMID:18070883
Biological Process	GO:0010628	positive regulation of gene expression	SPRY2	IMP		Human	PMID:18070883
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	SPRY2	IMP		Human	PMID:18070883
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	SPRY2	IMP		Human	PMID:18070883
Biological Process	GO:0060541	respiratory system development	Spry2	IDA		Mouse	PMID:11287183
Biological Process	GO:0007605	sensory perception of sound	Spry2	IMP	MGI:MGI:3578633	Mouse	PMID:15809037
Biological Process	GO:0060841	venous blood vessel development	spry2	IMP	ZFIN:ZDB-MRPHLNO-110107-3	Zfish	PMID:22207734

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.