Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPSB4
  • Mouse genes Spsb4
  • Rat genes Spsb4
  • Zfish genes spsb4a,spsb4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spsb4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SPSB4	IPI	UniProtKB:Q15369	Human	PMID:15601820
Molecular Function	GO:0005515	protein binding	SPSB4	IPI	UniProtKB:Q15369	Human	PMID:19159283
Molecular Function	GO:0005515	protein binding	SPSB4	IPI	UniProtKB:P35228	Human	PMID:21199876
Molecular Function	GO:0005515	protein binding	SPSB4	IPI	UniProtKB:Q93034	Human	PMID:21199876
Molecular Function	GO:0005515	protein binding	SPSB4	IPI	UniProtKB:P29323	Human	PMID:28931592
Molecular Function	GO:0005515	protein binding	SPSB4	IPI	UniProtKB:P54763	Human	PMID:28931592
Molecular Function	GO:0005515	protein binding	SPSB4	IPI	UniProtKB:P40337-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Spsb4	IPI	UniProtKB:Q96IZ0	Mouse	MGI:MGI:5917390|PMID:16369487
Molecular Function	GO:0005515	protein binding	Spsb4	IPI	UniProtKB:Q96IZ0	Mouse	MGI:MGI:5532915|PMID:20561531
Molecular Function	GO:0005515	protein binding	Spsb4	IPI	UniProtKB:P29477	Mouse	MGI:MGI:4820465|PMID:20603330
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	SPSB4	IPI	UniProtKB:P35228|UniProtKB:Q15369	Human	PMID:21199876
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	SPSB4	IPI	UniProtKB:P35228|UniProtKB:Q93034	Human	PMID:21199876
Cellular Component	GO:0005829	cytosol	SPSB4	IDA		Human	PMID:21199876
Biological Process	GO:1902916	positive regulation of protein polyubiquitination	SPSB4	IDA		Human	PMID:28931592
Biological Process	GO:0016567	protein ubiquitination	SPSB4	IDA		Human	PMID:21199876
Biological Process	GO:0042752	regulation of circadian rhythm	SPSB4	IMP		Human	PMID:26392558
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	SPSB4	IDA		Human	PMID:21199876
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	SPSB4	IMP		Human	PMID:26392558

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern