Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPTLC2
  • Mouse genes Sptlc2
  • Rat genes Sptlc2
  • Zfish genes sptlc2a,sptlc2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sptlc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004758	serine C-palmitoyltransferase activity	SPTLC2	IDA		Human	PMID:25332431
Molecular Function	GO:0004758	serine C-palmitoyltransferase activity	SPTLC2	IDA		Human	PMID:25691431
Molecular Function	GO:0004758	serine C-palmitoyltransferase activity	SPTLC2	IDA		Human	PMID:19416851
Molecular Function	GO:0004758	serine C-palmitoyltransferase activity	SPTLC2	IDA		Human	PMID:20920666
Molecular Function	GO:0004758	serine C-palmitoyltransferase activity	SPTLC2	IDA		Human	PMID:26573920
Molecular Function	GO:0004758	serine C-palmitoyltransferase activity	Sptlc2	IDA		Mouse	PMID:9363775
Cellular Component	GO:0005739	mitochondrion	Sptlc2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0017059	serine C-palmitoyltransferase complex	SPTLC2	IPI		Human	PMID:19416851
Cellular Component	GO:0017059	serine C-palmitoyltransferase complex	SPTLC2	IPI		Human	PMID:33558761
Cellular Component	GO:0017059	serine C-palmitoyltransferase complex	SPTLC2	IDA		Human	PMID:19416851
Biological Process	GO:0060612	adipose tissue development	Sptlc2	IMP		Mouse	MGI:MGI:6107161|PMID:27818258
Biological Process	GO:0060612	adipose tissue development	Sptlc2	IMP		Mouse	MGI:MGI:5917779|PMID:28698261
Biological Process	GO:0046513	ceramide biosynthetic process	SPTLC2	IDA		Human	PMID:25691431
Biological Process	GO:0046513	ceramide biosynthetic process	Sptlc2	IMP	MGI:MGI:3815117	Mouse	PMID:16216550
Biological Process	GO:1904504	positive regulation of lipophagy	SPTLC2	IDA		Human	PMID:25332431
Biological Process	GO:0046511	sphinganine biosynthetic process	Sptlc2	IDA		Mouse	PMID:9363775
Biological Process	GO:0030148	sphingolipid biosynthetic process	SPTLC2	IDA		Human	PMID:25332431
Biological Process	GO:0030148	sphingolipid biosynthetic process	SPTLC2	IDA		Human	PMID:26573920
Biological Process	GO:0030148	sphingolipid biosynthetic process	Sptlc2	IMP		Mouse	MGI:MGI:5917779|PMID:28698261
Biological Process	GO:0006686	sphingomyelin biosynthetic process	Sptlc2	IMP	MGI:MGI:3815117	Mouse	PMID:16216550
Biological Process	GO:0046512	sphingosine biosynthetic process	SPTLC2	IDA		Human	PMID:19416851
Biological Process	GO:0046512	sphingosine biosynthetic process	SPTLC2	IDA		Human	PMID:33558761
Biological Process	GO:0046512	sphingosine biosynthetic process	Sptlc2	IMP	MGI:MGI:3815117	Mouse	PMID:16216550

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern