Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPX
  • Mouse genes Spx
  • Rat genes Spx
  • Zfish genes spx
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spx

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005184	neuropeptide hormone activity	SPX	IMP		Human	PMID:17284679
Molecular Function	GO:0005515	protein binding	SPX	IPI	UniProtKB:Q6IN84	Human	PMID:32296183
Cellular Component	GO:0005737	cytoplasm	Spx	IDA		Rat	PMID:20530460|RGD:8693371
Cellular Component	GO:0031045	dense core granule	SPX	IDA		Human	PMID:17284679
Cellular Component	GO:0005615	extracellular space	SPX	IDA		Human	PMID:17284679
Cellular Component	GO:0005615	extracellular space	SPX	IDA		Human	PMID:19193193
Cellular Component	GO:0005615	extracellular space	SPX	IDA		Human	PMID:24550067
Cellular Component	GO:0005634	nucleus	spx	IDA		Zfish	PMID:29116147|ZFIN:ZDB-PUB-171109-5
Biological Process	GO:0042632	cholesterol homeostasis	spx	IMP		Zfish	PMID:29116147|ZFIN:ZDB-PUB-171109-5
Biological Process	GO:0042593	glucose homeostasis	spx	IMP		Zfish	PMID:29116147|ZFIN:ZDB-PUB-171109-5
Biological Process	GO:0044539	long-chain fatty acid import into cell	Spx	IDA		Mouse	MGI:MGI:5574430|PMID:24550067
Biological Process	GO:0044539	long-chain fatty acid import into cell	Spx	IDA		Rat	PMID:24550067|RGD:8693351
Biological Process	GO:0032099	negative regulation of appetite	Spx	IDA		Mouse	MGI:MGI:5574430|PMID:24550067
Biological Process	GO:0032099	negative regulation of appetite	Spx	IDA		Rat	PMID:24550067|RGD:8693351
Biological Process	GO:1903999	negative regulation of eating behavior	spx	IMP	ZFIN:ZDB-GENO-190527-1	Zfish	PMID:29116147
Biological Process	GO:0010459	negative regulation of heart rate	Spx	IDA		Rat	PMID:22038051|RGD:8693358
Biological Process	GO:0035814	negative regulation of renal sodium excretion	Spx	IDA		Rat	PMID:22038051|RGD:8693358
Biological Process	GO:1904306	positive regulation of gastro-intestinal system smooth muscle contraction	SPX	IMP		Human	PMID:17284679
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	Spx	IDA		Rat	PMID:22038051|RGD:8693358
Biological Process	GO:0051930	regulation of sensory perception of pain	Spx	IDA		Rat	PMID:22038051|RGD:8693358
Biological Process	GO:0070328	triglyceride homeostasis	spx	IMP		Zfish	PMID:29116147|ZFIN:ZDB-PUB-171109-5

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern