Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SQLE
  • Mouse genes Sqle
  • Rat genes Sqle
  • Zfish genes sqlea,sqleb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sqle

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071949	FAD binding	SQLE	IDA		Human	PMID:30626872
Molecular Function	GO:0005515	protein binding	SQLE	IPI	UniProtKB:K7EJ46	Human	PMID:29765154
Molecular Function	GO:0005515	protein binding	SQLE	IPI	UniProtKB:Q96BA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SQLE	IPI	UniProtKB:Q9H6H4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SQLE	IPI	UniProtKB:Q9NUH8	Human	PMID:32296183
Molecular Function	GO:0004506	squalene monooxygenase activity	SQLE	IDA		Human	PMID:30626872
Molecular Function	GO:0004506	squalene monooxygenase activity	Sqle	IDA		Rat	PMID:7814369|RGD:70024
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	SQLE	IDA		Human	PMID:30626872
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Sqle	IDA		Rat	PMID:6817796|RGD:1625702
Cellular Component	GO:0016020	membrane	SQLE	IDA		Human	PMID:30626872
Biological Process	GO:0006725	cellular aromatic compound metabolic process	Sqle	IDA		Rat	PMID:7814369|RGD:70024
Biological Process	GO:0008203	cholesterol metabolic process	Sqle	IMP		Rat	PMID:9300786|RGD:1625701
Biological Process	GO:0140042	lipid droplet formation	SQLE	IMP		Human	PMID:29765154
Biological Process	GO:0042127	regulation of cell population proliferation	SQLE	IMP		Human	PMID:29765154
Biological Process	GO:0010033	response to organic substance	Sqle	IDA		Rat	PMID:11520216|RGD:1625700
Biological Process	GO:0016126	sterol biosynthetic process	SQLE	IDA		Human	PMID:30626872

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern