Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SRCIN1
  • Mouse genes Srcin1
  • Rat genes Srcin1
  • Zfish genes srcin1a,srcin1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Srcin1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SRCIN1	IPI	UniProtKB:P56945	Human	PMID:14657239
Molecular Function	GO:0005515	protein binding	SRCIN1	IPI	UniProtKB:P12931	Human	PMID:17525734
Molecular Function	GO:0005515	protein binding	Srcin1	IPI	UniProtKB:Q14247	Mouse	MGI:MGI:4839438|PMID:19146815
Molecular Function	GO:0005515	protein binding	Srcin1	IPI	UniProtKB:Q9UPY8	Mouse	MGI:MGI:4839438|PMID:19146815
Molecular Function	GO:0005515	protein binding	Srcin1	IPI	UniProtKB:P00523	Mouse	MGI:MGI:4835144|PMID:17525734
Molecular Function	GO:0005515	protein binding	Srcin1	IPI	UniProtKB:O60504-2|UniProtKB:P07825	Mouse	MGI:MGI:4835139|PMID:18662323
Molecular Function	GO:0005515	protein binding	Srcin1	IPI	UniProtKB:P56945	Mouse	PMID:14657239
Molecular Function	GO:0005515	protein binding	Srcin1	IPI	RGD:3728	Rat	PMID:10625663|RGD:1299445
Molecular Function	GO:0005515	protein binding	Srcin1	IPI	UniProtKB:P60881	Rat	PMID:10625663|RGD:1299445
Molecular Function	GO:0019904	protein domain specific binding	Srcin1	IDA		Rat	PMID:10625663|RGD:1299445
Molecular Function	GO:0019901	protein kinase binding	SRCIN1	IDA		Human	PMID:17525734
Cellular Component	GO:0015629	actin cytoskeleton	SRCIN1	IDA		Human	PMID:14657239
Cellular Component	GO:0015629	actin cytoskeleton	Srcin1	IDA		Rat	PMID:10625663|RGD:1299445
Cellular Component	GO:0030424	axon	Srcin1	IDA		Rat	PMID:18662323|RGD:8553600
Cellular Component	GO:0005737	cytoplasm	SRCIN1	IDA		Human	PMID:19146815
Cellular Component	GO:0030425	dendrite	Srcin1	IDA		Rat	PMID:18662323|RGD:8553600
Cellular Component	GO:0030425	dendrite	Srcin1	IDA		Rat	PMID:19146815|RGD:8554119
Cellular Component	GO:0030175	filopodium	Srcin1	IDA		Rat	PMID:10625663|RGD:1299445
Cellular Component	GO:0098978	glutamatergic synapse	SRCIN1	IDA		Human	PMID:25771685
Cellular Component	GO:0098978	glutamatergic synapse	SRCIN1	IMP		Human	PMID:25771685
Cellular Component	GO:0098978	glutamatergic synapse	Srcin1	IMP		Mouse	PMID:28641114
Cellular Component	GO:0098978	glutamatergic synapse	Srcin1	IDA		Mouse	PMID:28641114
Cellular Component	GO:0030027	lamellipodium	Srcin1	IDA		Rat	PMID:10625663|RGD:1299445
Cellular Component	GO:0043005	neuron projection	Srcin1	IDA		Rat	PMID:10625663|RGD:1299445
Cellular Component	GO:0043025	neuronal cell body	Srcin1	IDA		Rat	PMID:10625663|RGD:1299445
Cellular Component	GO:0014069	postsynaptic density	Srcin1	IDA		Mouse	PMID:17114649
Cellular Component	GO:0014069	postsynaptic density	Srcin1	IDA		Rat	PMID:19146815|RGD:8554119
Cellular Component	GO:0045202	synapse	Srcin1	IDA		Rat	PMID:18662323|RGD:8553600
Biological Process	GO:0007162	negative regulation of cell adhesion	Srcin1	IDA		Mouse	PMID:14657239
Biological Process	GO:0050709	negative regulation of protein secretion	Srcin1	IMP		Rat	PMID:10625663|RGD:1299445
Biological Process	GO:0061099	negative regulation of protein tyrosine kinase activity	SRCIN1	IDA		Human	PMID:17525734
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	SRCIN1	IDA		Human	PMID:17525734
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	SRCIN1	IDA		Human	PMID:25771685
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	SRCIN1	IMP		Human	PMID:25771685
Biological Process	GO:0030334	regulation of cell migration	SRCIN1	IMP		Human	PMID:17525734
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis	SRCIN1	IMP		Human	PMID:19146815
Biological Process	GO:0051963	regulation of synapse assembly	Srcin1	IDA		Mouse	PMID:28641114
Biological Process	GO:0051963	regulation of synapse assembly	Srcin1	IMP		Mouse	PMID:28641114
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	SRCIN1	IMP		Human	PMID:17525734

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern