Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SRD5A2
  • Mouse genes Srd5a2
  • Rat genes Srd5a2
  • Zfish genes srd5a2a,srd5a2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Srd5a2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	Srd5a2	IMP	MGI:MGI:2178039	Mouse	PMID:11606430
Molecular Function	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	Srd5a2	IMP		Mouse	PMID:15249131
Molecular Function	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	Srd5a2	IDA		Rat	PMID:1527072|RGD:729939
Molecular Function	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	Srd5a2	IDA		Rat	PMID:7662592|RGD:2326072
Molecular Function	GO:0033218	amide binding	Srd5a2	IPI	PubChem_Compound:57363	Rat	PMID:9328210|RGD:4892035
Molecular Function	GO:0005515	protein binding	SRD5A2	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SRD5A2	IPI	UniProtKB:Q14749	Human	PMID:32296183
Molecular Function	GO:0009917	sterol 5-alpha reductase activity	SRD5A2	IDA		Human	PMID:1944596
Molecular Function	GO:0030283	testosterone dehydrogenase [NAD(P)] activity	SRD5A2	IDA		Human	PMID:10898110
Cellular Component	GO:0070852	cell body fiber	Srd5a2	IDA		Rat	PMID:15305365|RGD:4891939
Cellular Component	GO:0005737	cytoplasm	Srd5a2	IDA		Rat	PMID:15305365|RGD:4891939
Cellular Component	GO:0043025	neuronal cell body	Srd5a2	IDA		Rat	PMID:15305365|RGD:4891939
Biological Process	GO:0006702	androgen biosynthetic process	Srd5a2	IMP		Mouse	PMID:15249131
Biological Process	GO:0006702	androgen biosynthetic process	Srd5a2	IDA		Rat	PMID:12606426|RGD:4891962
Biological Process	GO:0008209	androgen metabolic process	SRD5A2	IDA		Human	PMID:1944596
Biological Process	GO:0008209	androgen metabolic process	Srd5a2	IDA		Rat	PMID:20954080|RGD:4891498
Biological Process	GO:0018879	biphenyl metabolic process	Srd5a2	IEP		Rat	PMID:16938428|RGD:4891899
Biological Process	GO:0060348	bone development	Srd5a2	IEP		Rat	PMID:15012600|RGD:4891061
Biological Process	GO:0018894	dibenzo-p-dioxin metabolic process	Srd5a2	IEP		Rat	PMID:11222880|RGD:4892000
Biological Process	GO:0030540	female genitalia development	Srd5a2	IEP		Rat	PMID:9142501|RGD:4892034
Biological Process	GO:0021766	hippocampus development	Srd5a2	IEP		Rat	PMID:21047951|RGD:4145527
Biological Process	GO:0021854	hypothalamus development	Srd5a2	IEP		Rat	PMID:15804399|RGD:4891928
Biological Process	GO:0030539	male genitalia development	Srd5a2	IMP	MGI:MGI:2178039	Mouse	PMID:11606430
Biological Process	GO:0030539	male genitalia development	Srd5a2	IEP		Rat	PMID:9142501|RGD:4892034
Biological Process	GO:0008584	male gonad development	SRD5A2	IMP		Human	PMID:1944596
Biological Process	GO:0008584	male gonad development	Srd5a2	IEP		Rat	PMID:12606426|RGD:4891962
Biological Process	GO:0018963	phthalate metabolic process	Srd5a2	IEP		Rat	PMID:20954080|RGD:4891498
Biological Process	GO:0032354	response to follicle-stimulating hormone	Srd5a2	IEP		Rat	PMID:12630924|RGD:1600068
Biological Process	GO:0031667	response to nutrient levels	Srd5a2	IEP		Rat	PMID:16425201|RGD:4891920
Biological Process	GO:0014070	response to organic cyclic compound	Srd5a2	IEP		Rat	PMID:17940878|RGD:4891890
Biological Process	GO:0010033	response to organic substance	Srd5a2	IDA		Rat	PMID:12443045|RGD:1600069
Biological Process	GO:0043434	response to peptide hormone	Srd5a2	IDA		Rat	PMID:12630924|RGD:1600068
Biological Process	GO:0048545	response to steroid hormone	Srd5a2	IEP		Rat	PMID:16076027|RGD:1600066
Biological Process	GO:0033574	response to testosterone	Srd5a2	IEP		Rat	PMID:16595696|RGD:4891918
Biological Process	GO:0009410	response to xenobiotic stimulus	Srd5a2	IEP		Rat	PMID:18978642|RGD:4891876
Biological Process	GO:0006694	steroid biosynthetic process	Srd5a2	IMP	MGI:MGI:2178039	Mouse	PMID:11606430
Biological Process	GO:0006694	steroid biosynthetic process	Srd5a2	IDA		Rat	PMID:1527072|RGD:729939
Biological Process	GO:0006694	steroid biosynthetic process	Srd5a2	IDA		Rat	PMID:7662592|RGD:2326072
Biological Process	GO:0006706	steroid catabolic process	Srd5a2	IDA		Rat	PMID:1527072|RGD:729939
Biological Process	GO:0061370	testosterone biosynthetic process	SRD5A2	IDA		Human	PMID:10898110

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern