Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SREBF1
  • Mouse genes Srebf1
  • Rat genes Srebf1
  • Zfish genes srebf1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Srebf1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Srebf1	IDA		Mouse	PMID:17074803
Molecular Function	GO:0003682	chromatin binding	Srebf1	IDA		Mouse	PMID:15637161
Molecular Function	GO:0003682	chromatin binding	Srebf1	IDA		Mouse	PMID:19564420
Molecular Function	GO:0003682	chromatin binding	Srebf1	IDA		Rat	PMID:19371623|RGD:8693606
Molecular Function	GO:0003677	DNA binding	Srebf1	IDA		Mouse	MGI:MGI:5294536|PMID:19244231
Molecular Function	GO:0003677	DNA binding	Srebf1	IDA		Mouse	PMID:11829742
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	SREBF1	IDA		Human	PMID:31501273
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Srebf1	IDA		Rat	PMID:16407292|RGD:8553473
Molecular Function	GO:0003700	DNA-binding transcription factor activity	SREBF1	IDA		Human	PMID:16407292
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	SREBF1	IDA		Human	PMID:12177166
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	SREBF1	IMP		Human	PMID:32497488
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Srebf1	IDA		Mouse	MGI:MGI:3623165|PMID:9062341
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Srebf1	IDA		Mouse	MGI:MGI:83216|PMID:8833906
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Srebf1	IMP		Mouse	MGI:MGI:5287349|PMID:21531336
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Srebf1	IDA		Mouse	PMID:22331133
Molecular Function	GO:0004879	nuclear receptor activity	SREBF1	IDA		Human	PMID:23610160
Molecular Function	GO:0005515	protein binding	SREBF1	IPI	UniProtKB:P54253	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	SREBF1	IPI	UniProtKB:Q13285	Human	PMID:23610160
Molecular Function	GO:0005515	protein binding	SREBF1	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SREBF1	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Srebf1	IPI	UniProtKB:Q923E4	Mouse	MGI:MGI:5315679|PMID:20817729
Molecular Function	GO:0005515	protein binding	Srebf1	IPI	UniProtKB:P53566	Mouse	MGI:MGI:3703854|PMID:17290224
Molecular Function	GO:0005515	protein binding	Srebf1	IPI	PR:Q8VCZ7	Mouse	PMID:22331133
Molecular Function	GO:0005515	protein binding	Srebf1	IPI	PR:P97496	Mouse	PMID:17074803
Molecular Function	GO:0005515	protein binding	Srebf1	IPI	PR:Q9D030	Mouse	PMID:14654692
Molecular Function	GO:0005515	protein binding	Srebf1	IPI	PR:P49698	Mouse	PMID:17636037
Molecular Function	GO:0005515	protein binding	Srebf1	IPI	PR:Q3TKT4	Mouse	PMID:17074803
Molecular Function	GO:0005515	protein binding	Srebf1	IPI	PR:Q6DIC0	Mouse	PMID:17074803
Molecular Function	GO:0019901	protein kinase binding	Srebf1	IPI	UniProtKB:Q60670	Mouse	MGI:MGI:5294536|PMID:19244231
Molecular Function	GO:0019901	protein kinase binding	Srebf1	IPI	UniProtKB:Q5EG47|UniProtKB:Q8BRK8	Mouse	MGI:MGI:5005039|PMID:21459323
Molecular Function	GO:0044877	protein-containing complex binding	Srebf1	IPI	RGD:1309378|RGD:1350460	Rat	PMID:19158095|RGD:2308803
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Srebf1	IDA		Mouse	MGI:MGI:5426758|PMID:22331133
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Srebf1	IDA		Mouse	PMID:22331133
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Srebf1	IDA		Rat	PMID:16407292|RGD:8553473
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SREBF1	IDA		Human	PMID:23610160
Molecular Function	GO:0043565	sequence-specific DNA binding	Srebf1	IDA		Mouse	PMID:14654692
Molecular Function	GO:0043565	sequence-specific DNA binding	Srebf1	IDA		Rat	PMID:9786926|RGD:2308843
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	SREBF1	IDA		Human	PMID:28473536
Molecular Function	GO:0032810	sterol response element binding	SREBF1	IDA		Human	PMID:16407292
Molecular Function	GO:0032810	sterol response element binding	SREBF1	IDA		Human	PMID:31501273
Molecular Function	GO:0001221	transcription coregulator binding	SREBF1	IPI	UniProtKB:Q6STE5	Human	PMID:14701856
Cellular Component	GO:0005737	cytoplasm	Srebf1	IDA		Mouse	MGI:MGI:5005039|PMID:21459323
Cellular Component	GO:0005737	cytoplasm	Srebf1	IDA		Mouse	PMID:16100574
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Srebf1	IDA		Rat	PMID:19158095|RGD:2308803
Cellular Component	GO:0016020	membrane	Srebf1	IDA		Mouse	MGI:MGI:1927704|PMID:11090130
Cellular Component	GO:0005634	nucleus	SREBF1	IDA		Human	PMID:15358760
Cellular Component	GO:0005634	nucleus	SREBF1	IMP		Human	PMID:32497488
Cellular Component	GO:0005634	nucleus	Srebf1	IDA		Mouse	MGI:MGI:1927704|PMID:11090130
Cellular Component	GO:0005634	nucleus	Srebf1	IDA		Mouse	MGI:MGI:5005039|PMID:21459323
Cellular Component	GO:0005634	nucleus	Srebf1	IDA		Mouse	PMID:22331133
Cellular Component	GO:0005634	nucleus	Srebf1	IDA		Rat	PMID:15944339|RGD:1625196
Cellular Component	GO:0032991	protein-containing complex	Srebf1	IDA		Rat	PMID:19158095|RGD:2308803
Biological Process	GO:0007568	aging	Srebf1	IEP		Rat	PMID:16741953|RGD:1581819
Biological Process	GO:0071398	cellular response to fatty acid	Srebf1	IEP		Rat	PMID:19332540|RGD:7242708
Biological Process	GO:0032869	cellular response to insulin stimulus	Srebf1	IEP		Rat	PMID:10207099|RGD:2308847
Biological Process	GO:0032869	cellular response to insulin stimulus	Srebf1	IEP		Rat	PMID:19158095|RGD:2308803
Biological Process	GO:0009267	cellular response to starvation	Srebf1	IDA		Mouse	MGI:MGI:3700436|PMID:16407292
Biological Process	GO:0009267	cellular response to starvation	Srebf1	IDA		Rat	PMID:16407292|RGD:8553473
Biological Process	GO:0006695	cholesterol biosynthetic process	Srebf1	IMP	MGI:MGI:2177958	Mouse	PMID:9329978
Biological Process	GO:0008203	cholesterol metabolic process	Srebf1	IMP		Rat	PMID:18071061|RGD:1643359
Biological Process	GO:0007623	circadian rhythm	Srebf1	IEP		Mouse	MGI:MGI:5574300|PMID:19786558
Biological Process	GO:0031018	endocrine pancreas development	srebf1	IMP	ZFIN:ZDB-MRPHLNO-160621-57	Zfish	PMID:26963759
Biological Process	GO:0045444	fat cell differentiation	Srebf1	IMP		Mouse	PMID:22331133
Biological Process	GO:0008286	insulin receptor signaling pathway	Srebf1	IDA		Mouse	PMID:17074803
Biological Process	GO:0030073	insulin secretion	Srebf1	IMP	MGI:MGI:2177773	Mouse	PMID:16890542
Biological Process	GO:0008610	lipid biosynthetic process	SREBF1	IMP		Human	PMID:32497488
Biological Process	GO:0008610	lipid biosynthetic process	Srebf1	IDA		Mouse	MGI:MGI:5005039|PMID:21459323
Biological Process	GO:0010876	lipid localization	Srebf1	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0001889	liver development	srebf1	IGI	ZFIN:ZDB-GENE-040702-7	Zfish	PMID:26884397
Biological Process	GO:0001889	liver development	srebf1	IGI	ZFIN:ZDB-GENE-040312-3	Zfish	PMID:26884397
Biological Process	GO:0030324	lung development	Srebf1	IEP		Rat	PMID:12896875|RGD:1304415
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	Srebf1	IDA		Mouse	PMID:22331133
Biological Process	GO:0046676	negative regulation of insulin secretion	Srebf1	IMP	MGI:MGI:2177773	Mouse	PMID:16890542
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Srebf1	IGI	MGI:MGI:1097691	Mouse	PMID:17636037
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Srebf1	IGI	MGI:MGI:109128	Mouse	PMID:17636037
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Srebf1	IDA		Mouse	PMID:17074803
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Srebf1	IGI	MGI:MGI:1276533	Mouse	PMID:17636037
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Srebf1	IGI	MGI:MGI:1342774	Mouse	PMID:17636037
Biological Process	GO:1990798	pancreas regeneration	srebf1	IMP	ZFIN:ZDB-MRPHLNO-160621-57	Zfish	PMID:26963759
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	SREBF1	IDA		Human	PMID:12177166
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	SREBF1	IMP		Human	PMID:12177166
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	Srebf1	IDA		Mouse	MGI:MGI:83216|PMID:8833906
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	Srebf1	IDA		Mouse	MGI:MGI:3623165|PMID:9062341
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	Srebf1	IMP	MGI:MGI:2177959	Mouse	PMID:16046411
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	Srebf1	IMP	MGI:MGI:2177958	Mouse	PMID:9329978
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Srebf1	IDA		Mouse	MGI:MGI:1927704|PMID:11090130
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Srebf1	IMP		Rat	PMID:10207099|RGD:2308847
Biological Process	GO:0045089	positive regulation of innate immune response	Srebf1	IMP		Mouse	MGI:MGI:5287349|PMID:21531336
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	Srebf1	IMP		Mouse	MGI:MGI:5287349|PMID:21531336
Biological Process	GO:1902895	positive regulation of miRNA transcription	SREBF1	IDA		Human	PMID:31501273
Biological Process	GO:1902895	positive regulation of miRNA transcription	Srebf1	IDA		Mouse	MGI:MGI:5501359|PMID:23823476
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SREBF1	IGI	UniProtKB:Q13285	Human	PMID:23610160
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SREBF1	IDA		Human	PMID:26437365
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SREBF1	IDA		Human	PMID:31501273
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Srebf1	IDA		Mouse	PMID:14654692
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Srebf1	IDA		Mouse	PMID:9329978
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Srebf1	IDA		Mouse	PMID:18060044
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Srebf1	IDA		Mouse	PMID:17074803
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Srebf1	IDA		Mouse	PMID:16890542
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Srebf1	IDA		Rat	PMID:16407292|RGD:8553473
Biological Process	GO:0010867	positive regulation of triglyceride biosynthetic process	Srebf1	IDA		Mouse	MGI:MGI:5294536|PMID:19244231
Biological Process	GO:0010867	positive regulation of triglyceride biosynthetic process	Srebf1	IMP	MGI:MGI:2177959	Mouse	PMID:16046411
Biological Process	GO:1903146	regulation of autophagy of mitochondrion	SREBF1	IMP		Human	PMID:24912190
Biological Process	GO:1903010	regulation of bone development	srebf1	IMP	ZFIN:ZDB-GENO-220707-1	Zfish	PMID:33068391
Biological Process	GO:0006355	regulation of DNA-templated transcription	Srebf1	IDA		Mouse	MGI:MGI:5005039|PMID:21459323
Biological Process	GO:0006355	regulation of DNA-templated transcription	Srebf1	IDA		Mouse	PMID:12242332
Biological Process	GO:0019217	regulation of fatty acid metabolic process	Srebf1	IMP	MGI:MGI:4124835	Mouse	PMID:19564420
Biological Process	GO:0003062	regulation of heart rate by chemical signal	Srebf1	IMP	MGI:MGI:2177773	Mouse	PMID:18060044
Biological Process	GO:0050796	regulation of insulin secretion	Srebf1	IMP	MGI:MGI:2177958	Mouse	PMID:18178930
Biological Process	GO:0019216	regulation of lipid metabolic process	srebf1	IMP	ZFIN:ZDB-GENO-220707-1	Zfish	PMID:33068391
Biological Process	GO:0019216	regulation of lipid metabolic process	srebf1	IMP	ZFIN:ZDB-GENO-220707-2	Zfish	PMID:33068391
Biological Process	GO:0010883	regulation of lipid storage	Srebf1	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0031647	regulation of protein stability	SREBF1	IMP		Human	PMID:24912190
Biological Process	GO:1903214	regulation of protein targeting to mitochondrion	SREBF1	IMP		Human	PMID:24912190
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Srebf1	IDA		Mouse	MGI:MGI:3623165|PMID:9062341
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Srebf1	IMP		Mouse	MGI:MGI:5287349|PMID:21531336
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Srebf1	IDA		Mouse	MGI:MGI:83216|PMID:8833906
Biological Process	GO:0051591	response to cAMP	Srebf1	IEP		Rat	PMID:10207099|RGD:2308847
Biological Process	GO:0045471	response to ethanol	Srebf1	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0070542	response to fatty acid	Srebf1	IEP		Rat	PMID:16222032|RGD:2308856
Biological Process	GO:0032094	response to food	Srebf1	IEP		Rat	PMID:19357831|RGD:2308802
Biological Process	GO:0033762	response to glucagon	Srebf1	IEP		Rat	PMID:10207099|RGD:2308847
Biological Process	GO:0009749	response to glucose	Srebf1	IMP	MGI:MGI:2177958	Mouse	PMID:18178930
Biological Process	GO:0033993	response to lipid	Srebf1	IEP		Rat	PMID:12421847|RGD:2308833
Biological Process	GO:0014070	response to organic cyclic compound	Srebf1	IEP		Rat	PMID:19371623|RGD:8693606
Biological Process	GO:0014070	response to organic cyclic compound	Srebf1	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0043434	response to peptide hormone	Srebf1	IEP		Rat	PMID:18801905|RGD:2308855
Biological Process	GO:0032570	response to progesterone	Srebf1	IEP		Rat	PMID:11278421|RGD:2308838
Biological Process	GO:0032526	response to retinoic acid	Srebf1	IEP		Rat	PMID:9121491|RGD:2308848
Biological Process	GO:0009410	response to xenobiotic stimulus	Srebf1	IEP		Rat	PMID:17526932|RGD:2308820
Biological Process	GO:0009410	response to xenobiotic stimulus	Srebf1	IEP		Rat	PMID:18171911|RGD:2298915
Biological Process	GO:0032933	SREBP signaling pathway	SREBF1	IDA		Human	PMID:27614840
Biological Process	GO:0032933	SREBP signaling pathway	SREBF1	IMP		Human	PMID:27614840
Biological Process	GO:0006366	transcription by RNA polymerase II	Srebf1	IDA		Mouse	PMID:16890542
Biological Process	GO:0003323	type B pancreatic cell development	srebf1	IMP	ZFIN:ZDB-MRPHLNO-160621-57	Zfish	PMID:26963759

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern