Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SREBF2
  • Mouse genes Srebf2
  • Rat genes Srebf2
  • Zfish genes srebf2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Srebf2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Srebf2	IDA		Rat	PMID:19470373|RGD:2308817
Molecular Function	GO:0003677	DNA binding	Srebf2	IDA		Mouse	PMID:11829742
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Srebf2	IDA		Mouse	PMID:12242332
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Srebf2	IDA		Mouse	PMID:11739104
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	SREBF2	IDA		Human	PMID:12177166
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	SREBF2	IDA		Human	PMID:15358760
Molecular Function	GO:0070888	E-box binding	SREBF2	IDA		Human	PMID:15358760
Molecular Function	GO:0005515	protein binding	SREBF2	IPI	UniProtKB:P08047	Human	PMID:10976766
Molecular Function	GO:0005515	protein binding	SREBF2	IPI	UniProtKB:P41235	Human	PMID:12855700
Molecular Function	GO:0005515	protein binding	SREBF2	IPI	UniProtKB:Q92793	Human	PMID:16799563
Molecular Function	GO:0005515	protein binding	SREBF2	IPI	UniProtKB:Q96RN5	Human	PMID:16799563
Molecular Function	GO:0005515	protein binding	SREBF2	IPI	UniProtKB:Q8WU17	Human	PMID:19706601
Molecular Function	GO:0005515	protein binding	SREBF2	IPI	UniProtKB:P08047	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	SREBF2	IPI	UniProtKB:P04637	Human	PMID:22265415
Molecular Function	GO:0005515	protein binding	SREBF2	IPI	UniProtKB:Q13952-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SREBF2	IPI	UniProtKB:Q14192	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SREBF2	IPI	UniProtKB:P97260	Human	PMID:9242699
Molecular Function	GO:0005515	protein binding	Srebf2	IPI	UniProtKB:Q9JM73	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SREBF2	IDA		Human	PMID:15358760
Molecular Function	GO:0043565	sequence-specific DNA binding	Srebf2	IDA		Rat	PMID:12446768|RGD:628485
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	SREBF2	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Srebf2	IDA		Mouse	PMID:11739104
Cellular Component	GO:0005737	cytoplasm	SREBF2	IDA		Human	PMID:12941800
Cellular Component	GO:0005737	cytoplasm	SREBF2	IDA		Human	PMID:19098903
Cellular Component	GO:0005737	cytoplasm	Srebf2	IDA		Mouse	PMID:16100574
Cellular Component	GO:0005737	cytoplasm	Srebf2	IDA		Rat	PMID:19124072|RGD:2308818
Cellular Component	GO:0030425	dendrite	Srebf2	IDA		Rat	PMID:19124072|RGD:2308818
Cellular Component	GO:0005783	endoplasmic reticulum	SREBF2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	SREBF2	IDA		Human	PMID:12202038
Cellular Component	GO:0005783	endoplasmic reticulum	SREBF2	IDA		Human	PMID:12941800
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	SREBF2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Srebf2	IDA		Rat	PMID:16741953|RGD:1581819
Cellular Component	GO:0016020	membrane	Srebf2	IDA		Mouse	MGI:MGI:1927704|PMID:11090130
Cellular Component	GO:0005654	nucleoplasm	SREBF2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	SREBF2	IDA		Human	PMID:12202038
Cellular Component	GO:0005634	nucleus	SREBF2	IDA		Human	PMID:12242332
Cellular Component	GO:0005634	nucleus	SREBF2	IDA		Human	PMID:12941800
Cellular Component	GO:0005634	nucleus	SREBF2	IDA		Human	PMID:15358760
Cellular Component	GO:0005634	nucleus	SREBF2	IDA		Human	PMID:19098903
Cellular Component	GO:0005634	nucleus	Srebf2	IDA		Mouse	MGI:MGI:1927704|PMID:11090130
Cellular Component	GO:0005634	nucleus	Srebf2	IDA		Mouse	MGI:MGI:6437000|PMID:10397761
Cellular Component	GO:0005634	nucleus	Srebf2	IDA		Rat	PMID:15944339|RGD:1625196
Cellular Component	GO:0032937	SREBP-SCAP-Insig complex	SREBF2	IDA		Human	PMID:12202038
Cellular Component	GO:0032937	SREBP-SCAP-Insig complex	SREBF2	IDA		Human	PMID:12242332
Biological Process	GO:0007568	aging	Srebf2	IEP		Rat	PMID:16741953|RGD:1581819
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	SREBF2	IEP		Human	PMID:15358760
Biological Process	GO:0009267	cellular response to starvation	SREBF2	IMP		Human	PMID:25339898
Biological Process	GO:0042632	cholesterol homeostasis	Srebf2	IGI	MGI:MGI:3619343	Mouse	PMID:20466882
Biological Process	GO:0001889	liver development	srebf2	IGI	ZFIN:ZDB-GENE-040312-3	Zfish	PMID:26884397
Biological Process	GO:0001889	liver development	srebf2	IGI	ZFIN:ZDB-GENE-040702-7	Zfish	PMID:26884397
Biological Process	GO:0090370	negative regulation of cholesterol efflux	SREBF2	IDA		Human	PMID:15358760
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SREBF2	IDA		Human	PMID:15358760
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SREBF2	IDA		Human	PMID:19098903
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	SREBF2	IDA		Human	PMID:12177166
Biological Process	GO:0010886	positive regulation of cholesterol storage	SREBF2	IDA		Human	PMID:15358760
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Srebf2	IMP		Rat	PMID:19470373|RGD:2308817
Biological Process	GO:1902895	positive regulation of miRNA transcription	Srebf2	IDA		Mouse	MGI:MGI:5501359|PMID:23823476
Biological Process	GO:1903955	positive regulation of protein targeting to mitochondrion	SREBF2	HMP		Human	PMID:24912190
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SREBF2	IDA		Human	PMID:12446768
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SREBF2	IDA		Human	PMID:12242332
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Srebf2	IDA		Mouse	PMID:16890542
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Srebf2	IDA		Rat	PMID:12446768|RGD:628485
Biological Process	GO:1903146	regulation of autophagy of mitochondrion	SREBF2	HMP		Human	PMID:24912190
Biological Process	GO:0006355	regulation of DNA-templated transcription	Srebf2	IDA		Mouse	PMID:12242332
Biological Process	GO:0008593	regulation of Notch signaling pathway	srebf2	IMP		Zfish	PMID:30705153|ZFIN:ZDB-PUB-190917-4
Biological Process	GO:0009725	response to hormone	Srebf2	IMP		Rat	PMID:19470373|RGD:2308817
Biological Process	GO:0010288	response to lead ion	Srebf2	IEP		Rat	PMID:16705668|RGD:2308832
Biological Process	GO:0033993	response to lipid	Srebf2	IEP		Rat	PMID:17709436|RGD:2308819
Biological Process	GO:0009410	response to xenobiotic stimulus	Srebf2	IEP		Rat	PMID:11551527|RGD:2308837
Biological Process	GO:0007283	spermatogenesis	Srebf2	IEP		Rat	PMID:16723505|RGD:2308831
Biological Process	GO:0032933	SREBP signaling pathway	SREBF2	IDA		Human	PMID:27614840
Biological Process	GO:0032933	SREBP signaling pathway	SREBF2	IMP		Human	PMID:27614840

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern