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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Srf

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Srf
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0003682chromatin bindingSrfIDAMousePMID:21379568
Molecular FunctionGO:0031490chromatin DNA bindingSrfIDAMousePMID:18458156
Molecular FunctionGO:0003677DNA bindingSrfIDAMousePMID:21098124
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificSRFIDAHumanPMID:20808827
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificSRFIGIUniProtKB:Q969V6HumanPMID:23764775
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificSrfIDAMouseMGI:MGI:5009475|PMID:19783823
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificSrfIDAMouseMGI:MGI:2136697|PMID:11439182
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificSrfIDAMousePMID:22106411
Molecular FunctionGO:0003700DNA-binding transcription factor activitySRFIMPHumanPMID:18296735
Molecular FunctionGO:0003700DNA-binding transcription factor activitySRFIDAHumanPMID:3203386
Molecular FunctionGO:0003700DNA-binding transcription factor activitySrfIDAMouseMGI:MGI:6201839|PMID:24732378
Molecular FunctionGO:0003700DNA-binding transcription factor activitySrfIDAMouseMGI:MGI:6202299|PMID:12732141
Molecular FunctionGO:0003700DNA-binding transcription factor activitySrfIDAMousePMID:12525493
Molecular FunctionGO:0003700DNA-binding transcription factor activitySrfIDAMousePMID:20534669
Molecular FunctionGO:0003700DNA-binding transcription factor activitySrfIDAMousePMID:8900044
Molecular FunctionGO:0000981DNA-binding transcription factor activity, RNA polymerase II-specificSrfIDAMousePMID:21379568
Molecular FunctionGO:0140297DNA-binding transcription factor bindingSRFIPIUniProtKB:P98177HumanPMID:16054032
Molecular FunctionGO:0140297DNA-binding transcription factor bindingSRFIPIUniProtKB:P97436HumanPMID:18296735
Molecular FunctionGO:0140297DNA-binding transcription factor bindingSRFIPIUniProtKB:Q99801HumanPMID:18296735
Molecular FunctionGO:0042826histone deacetylase bindingSrfIPIRGD:619979RatPMID:12663674|RGD:9681440
Molecular FunctionGO:0070878primary miRNA bindingSrfIDAMouseMGI:MGI:5688838|PMID:21303526
Molecular FunctionGO:0005515protein bindingSRFIPIUniProtKB:Q8IZQ8HumanPMID:12397177
Molecular FunctionGO:0005515protein bindingSRFIPIUniProtKB:Q969V6HumanPMID:12397177
Molecular FunctionGO:0005515protein bindingSRFIPIUniProtKB:Q9ULH7HumanPMID:12397177
Molecular FunctionGO:0005515protein bindingSRFIPIUniProtKB:Q969V6HumanPMID:14565952
Molecular FunctionGO:0005515protein bindingSRFIPIUniProtKB:Q9ULH7HumanPMID:14565952
Molecular FunctionGO:0005515protein bindingSRFIPIUniProtKB:P85037HumanPMID:17670796
Molecular FunctionGO:0005515protein bindingSRFIPIUniProtKB:O60711HumanPMID:18497331
Molecular FunctionGO:0005515protein bindingSRFIPIUniProtKB:Q8N9R8HumanPMID:19350017
Molecular FunctionGO:0005515protein bindingSRFIPIUniProtKB:Q969V6HumanPMID:19350017
Molecular FunctionGO:0005515protein bindingSRFIPIUniProtKB:O95897HumanPMID:25298399
Molecular FunctionGO:0005515protein bindingSRFIPIUniProtKB:P35269HumanPMID:7854423
Molecular FunctionGO:0005515protein bindingSRFIPIUniProtKB:P42582HumanPMID:8887666
Molecular FunctionGO:0005515protein bindingSrfIPIUniProtKB:P59759MouseMGI:MGI:2663933|PMID:12397177
Molecular FunctionGO:0005515protein bindingSrfIPIUniProtKB:Q8K4J6MouseMGI:MGI:6202299|PMID:12732141
Molecular FunctionGO:0005515protein bindingSrfIPIUniProtKB:Q8C8N2|UniProtKB:Q8K4J6MouseMGI:MGI:3850304|PMID:19350017
Molecular FunctionGO:0005515protein bindingSrfIPIUniProtKB:Q3U1N2MouseMGI:MGI:3688344|PMID:15102471
Molecular FunctionGO:0005515protein bindingSrfIPIPR:P97474-3MousePMID:18458156
Molecular FunctionGO:0005515protein bindingSrfIPIPR:P79457MousePMID:22192413
Molecular FunctionGO:0005515protein bindingSrfIPIPR:Q64318MousePMID:16824956
Molecular FunctionGO:0005515protein bindingSrfIPIPR:Q3TKT4MousePMID:19342595
Molecular FunctionGO:0005515protein bindingSrfIPIPR:O08686MousePMID:11278942
Molecular FunctionGO:0005515protein bindingSrfIPIPR:P79457MousePMID:23028370
Molecular FunctionGO:0005515protein bindingSrfIPIPR:Q8VIM5MousePMID:17030628
Molecular FunctionGO:0005515protein bindingSrfIPIMGI:MGI:2137495MousePMID:18945672
Molecular FunctionGO:0005515protein bindingSrfIPIPR:P13297MousePMID:17030628
Molecular FunctionGO:0005515protein bindingSrfIPIMGI:MGI:2137495MousePMID:19342595
Molecular FunctionGO:0005515protein bindingSrfIPIRGD:1311869RatPMID:23110084|RGD:9586362
Molecular FunctionGO:0042803protein homodimerization activitySRFIPIUniProtKB:P11831HumanPMID:3203386
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSRFIDAHumanPMID:1509260
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSrfIDAMouseMGI:MGI:5009475|PMID:19783823
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSrfIDAMousePMID:12486129
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSrfIDAMousePMID:17030628
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSrfIGIMGI:MGI:109617MousePMID:11278942
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSrfIDAMousePMID:8900044
Molecular FunctionGO:0061629RNA polymerase II-specific DNA-binding transcription factor bindingSrfIPIUniProtKB:Q8VIM5MouseMGI:MGI:2136697|PMID:11439182
Molecular FunctionGO:0043565sequence-specific DNA bindingSrfIDAMousePMID:20534669
Molecular FunctionGO:0043565sequence-specific DNA bindingSrfIDARatPMID:16822834|RGD:1580749
Molecular FunctionGO:1990837sequence-specific double-stranded DNA bindingSRFIDAHumanPMID:28473536
Molecular FunctionGO:0010736serum response element bindingSRFIDAHumanPMID:23764775
Molecular FunctionGO:0010736serum response element bindingSRFIDAHumanPMID:3203386
Molecular FunctionGO:0010736serum response element bindingSrfIDAMouseMGI:MGI:6202299|PMID:12732141
Molecular FunctionGO:0010736serum response element bindingSrfIDAMouseMGI:MGI:6201839|PMID:24732378
Molecular FunctionGO:0010736serum response element bindingSrfIDAMousePMID:2062642
Cellular ComponentGO:0000785chromatinSrfIDAMouseMGI:MGI:4839449|PMID:16427017
Cellular ComponentGO:0005737cytoplasmSrfIDAMousePMID:17576768
Cellular ComponentGO:0005634nucleusSRFIDAHumanPMID:2108863
Cellular ComponentGO:0005634nucleusSrfIDAMousePMID:15929941
Cellular ComponentGO:0005634nucleusSrfIDAMousePMID:17576768
Cellular ComponentGO:0005634nucleusSrfIDARatPMID:16822834|RGD:1580749
Cellular ComponentGO:0005634nucleussrfaIDAZfishPMID:18415940
Biological ProcessGO:0030036actin cytoskeleton organizationSrfIDAMouseMGI:MGI:6201839|PMID:24732378
Biological ProcessGO:0030036actin cytoskeleton organizationSrfIMPMGI:MGI:2181426,MGI:MGI:2385464MousePMID:15837932
Biological ProcessGO:0030036actin cytoskeleton organizationSrfIMPMGI:MGI:2445832,MGI:MGI:3522206MousePMID:20047077
Biological ProcessGO:0007015actin filament organizationSrfIMPMousePMID:18804439
Biological ProcessGO:0008306associative learningSrfIMPMGI:MGI:2385465,MGI:MGI:2678305MousePMID:16600861
Biological ProcessGO:0048675axon extensionSrfIMPMGI:MGI:3522206MousePMID:24623780
Biological ProcessGO:0070830bicellular tight junction assemblySrfIMPMGI:MGI:2445832,MGI:MGI:3522206MousePMID:20047077
Biological ProcessGO:0001569branching involved in blood vessel morphogenesisSrfIMPMousePMID:18804439
Biological ProcessGO:0060532bronchus cartilage developmentSrfIMPMGI:MGI:3522206MousePMID:24218621
Biological ProcessGO:0060379cardiac muscle cell myoblast differentiationSRFIGIUniProtKB:Q9JM73HumanPMID:19783823
Biological ProcessGO:0060379cardiac muscle cell myoblast differentiationSrfIGIUniProtKB:P11831MouseMGI:MGI:5009475|PMID:19783823
Biological ProcessGO:0055003cardiac myofibril assemblySrfIMPMGI:MGI:3522206,MGI:MGI:3522214MousePMID:15569937
Biological ProcessGO:0060947cardiac vascular smooth muscle cell differentiationSrfIMPMGI:MGI:3522206,MGI:MGI:3522214MousePMID:15569937
Biological ProcessGO:0002042cell migration involved in sprouting angiogenesisSRFIMPHumanPMID:15180964
Biological ProcessGO:0002042cell migration involved in sprouting angiogenesisSrfIMPMousePMID:18804439
Biological ProcessGO:0098609cell-cell adhesionSrfIMPMGI:MGI:2450311,MGI:MGI:3522206MousePMID:21401944
Biological ProcessGO:0007160cell-matrix adhesionSrfIMPMGI:MGI:2176073,MGI:MGI:3046779MousePMID:20709909
Biological ProcessGO:0007160cell-matrix adhesionSrfIMPMGI:MGI:2450311,MGI:MGI:3522206MousePMID:21401944
Biological ProcessGO:0007160cell-matrix adhesionSrfIMPMGI:MGI:3522206,MGI:MGI:3764698MousePMID:20525922
Biological ProcessGO:0071333cellular response to glucose stimulusSrfIEPRatPMID:20655308|RGD:5131625
Biological ProcessGO:0090398cellular senescenceSRFIMPHumanPMID:15282327
Biological ProcessGO:0030038contractile actin filament bundle assemblySrfIMPMGI:MGI:3522206,MGI:MGI:3522214MousePMID:15569937
Biological ProcessGO:0048589developmental growthSrfIMPMGI:MGI:2158696MousePMID:9799237
Biological ProcessGO:0035912dorsal aorta morphogenesisSrfIMPMGI:MGI:3522206,MGI:MGI:3522214MousePMID:15569937
Biological ProcessGO:0090136epithelial cell-cell adhesionSrfIMPMGI:MGI:2445832,MGI:MGI:3522206MousePMID:20047077
Biological ProcessGO:0010669epithelial structure maintenanceSrfIMPMGI:MGI:2445832,MGI:MGI:3522206MousePMID:20047077
Biological ProcessGO:0048821erythrocyte developmentSrfIMPMGI:MGI:2176073,MGI:MGI:3046779MousePMID:20709909
Biological ProcessGO:0061436establishment of skin barrierSrfIMPMGI:MGI:2445832,MGI:MGI:3522206MousePMID:20047077
Biological ProcessGO:0061029eyelid development in camera-type eyeSrfIMPMGI:MGI:2445832,MGI:MGI:3522206MousePMID:20047077
Biological ProcessGO:0060324face developmentSrfIMPMGI:MGI:3522206MousePMID:18952847
Biological ProcessGO:0046847filopodium assemblySrfIMPMousePMID:18804439
Biological ProcessGO:0030900forebrain developmentSrfIMPMGI:MGI:2158696MousePMID:20534669
Biological ProcessGO:0007369gastrulationSrfIMPMGI:MGI:2158696MousePMID:9799237
Biological ProcessGO:0007507heart developmentSrfIMPMGI:MGI:3046779MousePMID:15169892
Biological ProcessGO:0007507heart developmentSrfIMPMGI:MGI:2385465,MGI:MGI:2386742MousePMID:15929941
Biological ProcessGO:0001947heart loopingSrfIMPMGI:MGI:2385465,MGI:MGI:2386742MousePMID:15929941
Biological ProcessGO:0060347heart trabecula formationSrfIMPMGI:MGI:3522206,MGI:MGI:3522214MousePMID:15569937
Biological ProcessGO:0060218hematopoietic stem cell differentiationSrfIMPMGI:MGI:2176073,MGI:MGI:3046779MousePMID:20709909
Biological ProcessGO:0021766hippocampus developmentSrfIMPMGI:MGI:2181426,MGI:MGI:2385464MousePMID:15837932
Biological ProcessGO:0001701in utero embryonic developmentSrfIMPMGI:MGI:2158696MousePMID:9799237
Biological ProcessGO:0002521leukocyte differentiationSrfIMPMGI:MGI:2176073,MGI:MGI:3046779MousePMID:20709909
Biological ProcessGO:0007616long-term memorySrfIMPRatPMID:15816850|RGD:1581201
Biological ProcessGO:0060292long-term synaptic depressionSrfIMPMGI:MGI:2385465,MGI:MGI:2678305MousePMID:16600861
Biological ProcessGO:0060425lung morphogenesisSrfIMPMGI:MGI:3522206MousePMID:24218621
Biological ProcessGO:0061145lung smooth muscle developmentSrfIMPMGI:MGI:3522206MousePMID:24218621
Biological ProcessGO:0035855megakaryocyte developmentSrfIMPMGI:MGI:2176073,MGI:MGI:3046779MousePMID:20709909
Biological ProcessGO:0035855megakaryocyte developmentSrfIMPMGI:MGI:3522206,MGI:MGI:3764698MousePMID:20525922
Biological ProcessGO:0001707mesoderm formationSrfIMPMGI:MGI:2158696MousePMID:11060034
Biological ProcessGO:0001707mesoderm formationSrfIMPMGI:MGI:2158696MousePMID:9799237
Biological ProcessGO:0002011morphogenesis of an epithelial sheetSrfIMPMGI:MGI:2445832,MGI:MGI:3522206MousePMID:20047077
Biological ProcessGO:0046716muscle cell cellular homeostasisSrfIMPMGI:MGI:2385465MousePMID:15647354
Biological ProcessGO:1900222negative regulation of amyloid-beta clearanceSRFIMPHumanPMID:19098903
Biological ProcessGO:0030336negative regulation of cell migrationSrfIMPRatPMID:16081871|RGD:1581164
Biological ProcessGO:0008285negative regulation of cell population proliferationSrfIMPRatPMID:16081871|RGD:1581164
Biological ProcessGO:1902894negative regulation of miRNA transcriptionSrfIDAMouseMGI:MGI:5688838|PMID:21303526
Biological ProcessGO:0001764neuron migrationSrfIMPMGI:MGI:2181426,MGI:MGI:2385464MousePMID:15837932
Biological ProcessGO:0031175neuron projection developmentSrfIMPMGI:MGI:2181426,MGI:MGI:2385464MousePMID:19357276
Biological ProcessGO:0030168platelet activationSrfIMPMGI:MGI:3522206,MGI:MGI:3764698MousePMID:20525922
Biological ProcessGO:0030220platelet formationSrfIMPMGI:MGI:2176073,MGI:MGI:3046779MousePMID:20709909
Biological ProcessGO:0030220platelet formationSrfIMPMGI:MGI:3522206,MGI:MGI:3764698MousePMID:20525922
Biological ProcessGO:0045773positive regulation of axon extensionSrfIMPMGI:MGI:3522206MousePMID:24623780
Biological ProcessGO:0045773positive regulation of axon extensionSrfIGIMGI:MGI:98927MousePMID:24623780
Biological ProcessGO:0045773positive regulation of axon extensionSrfIGIMGI:MGI:1861437MousePMID:24623780
Biological ProcessGO:0045597positive regulation of cell differentiationSRFIDAHumanPMID:17576768
Biological ProcessGO:0051091positive regulation of DNA-binding transcription factor activitySRFIMPHumanPMID:18296735
Biological ProcessGO:0051091positive regulation of DNA-binding transcription factor activitySRFIDAHumanPMID:19098903
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionSrfIMPMouseMGI:MGI:5294532|PMID:19797053
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionSrfIDAMousePMID:20534669
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionSrfIMPRatPMID:16081871|RGD:1581164
Biological ProcessGO:0051491positive regulation of filopodium assemblySrfIMPMousePMID:18804439
Biological ProcessGO:1902895positive regulation of miRNA transcriptionSRFIGIUniProtKB:Q969V6HumanPMID:23764775
Biological ProcessGO:1902895positive regulation of miRNA transcriptionSrfIDAMouseMGI:MGI:5688838|PMID:21303526
Biological ProcessGO:1902895positive regulation of miRNA transcriptionSrfIDAMouseMGI:MGI:4354665|PMID:19578358
Biological ProcessGO:0045987positive regulation of smooth muscle contractionSRFIDAHumanPMID:17215356
Biological ProcessGO:0046016positive regulation of transcription by glucoseSrfIMPRatPMID:20655308|RGD:5131625
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISRFIDAHumanPMID:17576768
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISRFIDAHumanPMID:19578358
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISRFIGIUniProtKB:Q9JM73HumanPMID:19783823
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISRFIDAHumanPMID:3203386
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISRFIDAHumanPMID:8887666
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISrfIDAMouseMGI:MGI:5009475|PMID:19783823
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISrfIDAMouseMGI:MGI:6202299|PMID:12732141
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISrfIDAMouseMGI:MGI:6201839|PMID:24732378
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISrfIGIMGI:MGI:2137495MousePMID:18511849
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISrfIDAMousePMID:11278942
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISrfIGIMGI:MGI:1201674MousePMID:16824956
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISrfIDAMousePMID:8900044
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISrfIGIMGI:MGI:107516MousePMID:16510470
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISrfIGIMGI:MGI:1344313MousePMID:16824956
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISrfIMPMGI:MGI:3604097MousePMID:15929941
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISrfIGIMGI:MGI:108067MousePMID:16510470
Biological ProcessGO:0060261positive regulation of transcription initiation by RNA polymerase IISRFIDAHumanPMID:8887666
Biological ProcessGO:0045059positive thymic T cell selectionSrfIMPMGI:MGI:2449947,MGI:MGI:3046779MousePMID:21098124
Biological ProcessGO:0090009primitive streak formationSrfIMPMGI:MGI:2158696MousePMID:9799237
Biological ProcessGO:0030155regulation of cell adhesionSrfIMPMousePMID:18804439
Biological ProcessGO:0006355regulation of DNA-templated transcriptionSrfIDAMousePMID:12525493
Biological ProcessGO:0034097response to cytokineSRFIMPHumanPMID:15180964
Biological ProcessGO:0009725response to hormoneSRFIDAHumanPMID:17975004
Biological ProcessGO:0001666response to hypoxiaSRFIEPHumanPMID:19098903
Biological ProcessGO:0045214sarcomere organizationSrfIMPMGI:MGI:3522206,MGI:MGI:3522214MousePMID:15569937
Biological ProcessGO:0043589skin morphogenesisSrfIMPMGI:MGI:2445832,MGI:MGI:3522206MousePMID:20047077
Biological ProcessGO:0043149stress fiber assemblySrfIMPMGI:MGI:3522206,MGI:MGI:3764698MousePMID:20525922
Biological ProcessGO:0022028tangential migration from the subventricular zone to the olfactory bulbSrfIMPMGI:MGI:2181426,MGI:MGI:2385464MousePMID:15837932
Biological ProcessGO:0048538thymus developmentSrfIMPMGI:MGI:3522206MousePMID:18952847
Biological ProcessGO:0030878thyroid gland developmentSrfIMPMGI:MGI:3522206MousePMID:18952847
Biological ProcessGO:0060534trachea cartilage developmentSrfIMPMGI:MGI:3522206MousePMID:24218621
Biological ProcessGO:0006366transcription by RNA polymerase IISrfIMPMGI:MGI:3604097MousePMID:15929941
Biological ProcessGO:0006366transcription by RNA polymerase IISrfIGIMGI:MGI:2137495MousePMID:18511849
Biological ProcessGO:0001829trophectodermal cell differentiationSRFIDAHumanPMID:17576768

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory