Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SRSF1
  • Mouse genes Srsf1
  • Rat genes Srsf1
  • Zfish genes srsf1a,srsf1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Srsf1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0044547	DNA topoisomerase binding	SRSF1	IPI	UniProtKB:P11387	Human	PMID:9611241
Molecular Function	GO:0098772	molecular function regulator activity	Srsf1	IDA		Mouse	PMID:21822258
Molecular Function	GO:0003729	mRNA binding	SRSF1	IDA		Human	PMID:21984414
Molecular Function	GO:0003729	mRNA binding	Srsf1	IMP		Mouse	PMID:21822258
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:O54781	Human	PMID:10196197
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:O70551	Human	PMID:10196197
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:Q96SB4	Human	PMID:10196197
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:Q9UBU9	Human	PMID:15184380
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:P23511	Human	PMID:15243141
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:Q86X95	Human	PMID:15652350
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:Q96IZ7	Human	PMID:15798186
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:P08621	Human	PMID:18559666
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:Q01081	Human	PMID:18559666
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:Q9UBU9	Human	PMID:18596238
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:Q14684	Human	PMID:20926688
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:Q9H0G5	Human	PMID:21296756
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:O00463	Human	PMID:21822258
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:Q01081	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:Q9UBU9	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:Q96SB4	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:Q14684	Human	PMID:23604122
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:Q9Y5L0	Human	PMID:24449914
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:O00192	Human	PMID:24644279
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:P49759-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:P62995	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:Q15696	Human	PMID:9237760
Molecular Function	GO:0005515	protein binding	SRSF1	IPI	UniProtKB:O75475-2	Human	PMID:9885563
Molecular Function	GO:0005515	protein binding	Srsf1	IPI	UniProtKB:P08775|UniProtKB:Q8R409	Mouse	MGI:MGI:5553217|PMID:23663783
Molecular Function	GO:0005515	protein binding	Srsf1	IPI	UniProtKB:P70318	Mouse	MGI:MGI:5508562|PMID:20477871
Molecular Function	GO:0005515	protein binding	Srsf1	IPI	UniProtKB:B5TVM2|UniProtKB:Q8CBR1	Mouse	MGI:MGI:6810798|PMID:28785060
Molecular Function	GO:0005515	protein binding	Srsf1	IPI	UniProtKB:P70191	Mouse	MGI:MGI:5441108|PMID:23042150
Molecular Function	GO:0005515	protein binding	Srsf1	IPI	UniProtKB:Q8N7N6	Mouse	PMID:29563620
Molecular Function	GO:0005515	protein binding	Srsf1	IPI	UniProtKB:P70191	Mouse	PMID:21822258
Molecular Function	GO:0005515	protein binding	Srsf1	IPI	UniProtKB:Q8N7N6	Mouse	PMID:21822258
Molecular Function	GO:0043422	protein kinase B binding	Srsf1	IPI	RGD:2082	Rat	PMID:15684423|RGD:11039445
Molecular Function	GO:0003723	RNA binding	SRSF1	IDA		Human	PMID:19561594
Molecular Function	GO:0003723	RNA binding	SRSF1	IPI	EMBL:AF001540	Human	PMID:20797886
Molecular Function	GO:0003723	RNA binding	SRSF1	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	SRSF1	HDA		Human	PMID:22681889
Molecular Function	GO:0050733	RS domain binding	Srsf1	IPI	PR:Q9DBU6	Mouse	PMID:15798186
Cellular Component	GO:0071013	catalytic step 2 spliceosome	SRSF1	IDA		Human	PMID:11991638
Cellular Component	GO:0005737	cytoplasm	SRSF1	IDA		Human	PMID:24449914
Cellular Component	GO:0005737	cytoplasm	Srsf1	IDA		Rat	PMID:16288477|RGD:11038733
Cellular Component	GO:0016607	nuclear speck	SRSF1	IDA		Human	PMID:20797886
Cellular Component	GO:0016607	nuclear speck	SRSF1	IDA		Human	PMID:24644279
Cellular Component	GO:0016607	nuclear speck	Srsf1	IDA		Mouse	PMID:21191184
Cellular Component	GO:0016607	nuclear speck	Srsf1	IDA		Mouse	PMID:20729808
Cellular Component	GO:0005654	nucleoplasm	SRSF1	IDA		Human	PMID:9885563
Cellular Component	GO:0005634	nucleus	SRSF1	HDA		Human	PMID:21630459
Cellular Component	GO:0005634	nucleus	SRSF1	IDA		Human	PMID:21984414
Cellular Component	GO:0005634	nucleus	SRSF1	IDA		Human	PMID:24449914
Cellular Component	GO:0005634	nucleus	Srsf1	IDA		Mouse	MGI:MGI:6810798|PMID:28785060
Cellular Component	GO:0005634	nucleus	Srsf1	IPI	UniProtKB:Q8N7N6	Mouse	PMID:29563620
Cellular Component	GO:0005634	nucleus	Srsf1	IDA		Mouse	PMID:15615787
Cellular Component	GO:0005634	nucleus	Srsf1	IDA		Rat	PMID:16288477|RGD:11038733
Biological Process	GO:0000380	alternative mRNA splicing, via spliceosome	SRSF1	IDA		Human	PMID:8940107
Biological Process	GO:0000380	alternative mRNA splicing, via spliceosome	Srsf1	IMP		Rat	PMID:23462647|RGD:11038736
Biological Process	GO:0060048	cardiac muscle contraction	Srsf1	IGI	MGI:MGI:97272	Mouse	PMID:15652482
Biological Process	GO:0060048	cardiac muscle contraction	Srsf1	IGI	MGI:MGI:98283	Mouse	PMID:15652482
Biological Process	GO:0097398	cellular response to interleukin-17	Srsf1	IDA		Mouse	PMID:29563620
Biological Process	GO:0001701	in utero embryonic development	Srsf1	IMP	MGI:MGI:3530159	Mouse	PMID:15652482
Biological Process	GO:0097400	interleukin-17-mediated signaling pathway	Srsf1	IMP		Mouse	PMID:21822258
Biological Process	GO:0097400	interleukin-17-mediated signaling pathway	Srsf1	IDA		Mouse	PMID:21822258
Biological Process	GO:0097421	liver regeneration	Srsf1	IEP		Rat	PMID:23633480|RGD:9685423
Biological Process	GO:0000395	mRNA 5'-splice site recognition	SRSF1	IDA		Human	PMID:8940107
Biological Process	GO:0000395	mRNA 5'-splice site recognition	SRSF1	IDA		Human	PMID:9885563
Biological Process	GO:0048255	mRNA stabilization	Srsf1	IMP		Mouse	PMID:21822258
Biological Process	GO:0048255	mRNA stabilization	Srsf1	IDA		Mouse	PMID:21822258
Biological Process	GO:0048709	oligodendrocyte differentiation	Srsf1	IEP		Rat	PMID:16288477|RGD:11038733
Biological Process	GO:0033120	positive regulation of RNA splicing	Srsf1	IMP		Rat	PMID:16308321|RGD:11038784
Biological Process	GO:0034504	protein localization to nucleus	Srsf1	IDA		Mouse	PMID:29563620
Biological Process	GO:0110012	protein localization to P-body	Srsf1	IDA		Mouse	PMID:29563620
Biological Process	GO:0043484	regulation of RNA splicing	Srsf1	IMP		Mouse	MGI:MGI:6810798|PMID:28785060
Biological Process	GO:0008380	RNA splicing	Srsf1	IGI	MGI:MGI:97272	Mouse	PMID:15652482
Biological Process	GO:0008380	RNA splicing	Srsf1	IDA		Mouse	PMID:15798186
Biological Process	GO:0008380	RNA splicing	Srsf1	IGI	MGI:MGI:98283	Mouse	PMID:15652482
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	Srsf1	IDA		Mouse	PMID:21822258
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	Srsf1	IMP		Mouse	PMID:21822258

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern