Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes STAT2
  • Mouse genes Stat2
  • Rat genes Stat2
  • Zfish genes stat2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Stat2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003700	DNA-binding transcription factor activity	STAT2	IDA		Human	PMID:31127039
Molecular Function	GO:0003700	DNA-binding transcription factor activity	STAT2	IDA		Human	PMID:9020188
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	STAT2	IDA		Human	PMID:9020188
Molecular Function	GO:0042802	identical protein binding	STAT2	IPI	UniProtKB:P52630	Human	PMID:8605877
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P17181	Human	PMID:12220192
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P42224	Human	PMID:15825084
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P11207	Human	PMID:16227264
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P42224	Human	PMID:17923090
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P48551	Human	PMID:17923090
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:Q00978	Human	PMID:17923090
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P0C774	Human	PMID:18579593
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:Q77PU6	Human	PMID:20404187
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:Q00978	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P42224	Human	PMID:24065129
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:Q00978	Human	PMID:24065129
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P42224	Human	PMID:26966684
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P48551	Human	PMID:28165510
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:Q9UMW8	Human	PMID:28165510
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:Q00978	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:Q9UMW8	Human	PMID:31836668
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:Q9UMW8	Human	PMID:32092142
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P0DTC9	Human	PMID:32953130
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P29597	Human	PMID:32953130
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P0DTC9	Human	PMID:34471099
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P0DTC9	Human	PMID:34521819
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P29597	Human	PMID:34521819
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P42224	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P17181	Human	PMID:8605876
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P42224	Human	PMID:8605877
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P17181	Human	PMID:9121453
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P48551	Human	PMID:9121453
Molecular Function	GO:0005515	protein binding	STAT2	IPI	UniProtKB:P17181	Human	PMID:9677371
Molecular Function	GO:0005515	protein binding	Stat2	IPI	UniProtKB:O88544|UniProtKB:Q61179	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Stat2	IPI	UniProtKB:Q9D385	Mouse	MGI:MGI:3774679|PMID:18234692
Molecular Function	GO:0005515	protein binding	Stat2	IPI	UniProtKB:Q61179	Mouse	MGI:MGI:4455093|PMID:20211142
Molecular Function	GO:0044389	ubiquitin-like protein ligase binding	STAT2	IPI	UniProtKB:Q5T197	Human	PMID:27782195
Cellular Component	GO:0005737	cytoplasm	Stat2	IDA		Mouse	PMID:12634107
Cellular Component	GO:0005829	cytosol	STAT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070721	ISGF3 complex	STAT2	IPI		Human	PMID:24065129
Cellular Component	GO:0005634	nucleus	STAT2	IDA		Human	PMID:23139419
Cellular Component	GO:0005634	nucleus	Stat2	IDA		Mouse	PMID:12634107
Cellular Component	GO:0005886	plasma membrane	STAT2	IDA		Human	GO_REF:0000052
Biological Process	GO:0051607	defense response to virus	STAT2	IMP		Human	PMID:23391734
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	STAT2	IMP		Human	PMID:28165510
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	Stat2	IMP		Mouse	MGI:MGI:6508512|PMID:28165510
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	STAT2	IDA		Human	PMID:24065129
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	STAT2	IDA		Human	PMID:23139419
Biological Process	GO:0090140	regulation of mitochondrial fission	STAT2	IMP		Human	PMID:26122121
Biological Process	GO:0001932	regulation of protein phosphorylation	STAT2	IMP		Human	PMID:26122121
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	STAT2	IDA		Human	PMID:9020188
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	STAT2	IMP		Human	PMID:23391734
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	STAT2	IMP		Human	PMID:31836668
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	STAT2	IMP		Human	PMID:32092142
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	Stat2	IMP		Mouse	MGI:MGI:6508512|PMID:28165510
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	Stat2	IMP		Mouse	MGI:MGI:5619426|PMID:24598055

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern