Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes STAT4
  • Mouse genes Stat4
  • Rat genes
  • Zfish genes stat4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Stat4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Stat4	IDA		Mouse	PMID:12213961
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Stat4	IMP		Mouse	MGI:MGI:5543522|PMID:23772023
Molecular Function	GO:0042802	identical protein binding	STAT4	IPI	UniProtKB:Q14765	Human	PMID:18591661
Molecular Function	GO:0005515	protein binding	STAT4	IPI	UniProtKB:O43504	Human	PMID:22740693
Molecular Function	GO:0005515	protein binding	STAT4	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	STAT4	IPI	UniProtKB:Q9BVL2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Stat4	IPI	UniProtKB:Q9D385	Mouse	MGI:MGI:3774679|PMID:18234692
Molecular Function	GO:0005515	protein binding	Stat4	IPI	UniProtKB:P42225	Mouse	MGI:MGI:5311050|PMID:22306691
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Stat4	IDA		Mouse	MGI:MGI:5825437|PMID:12372421
Molecular Function	GO:0043565	sequence-specific DNA binding	Stat4	IDA		Mouse	PMID:11894097
Cellular Component	GO:0005634	nucleus	STAT4	IDA		Human	PMID:7638186
Cellular Component	GO:0005634	nucleus	Stat4	IDA		Mouse	PMID:12213961
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	STAT4	IPI		Human	PMID:18591661
Biological Process	GO:0071310	cellular response to organic substance	Stat4	IDA		Mouse	PMID:20399120
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Stat4	IDA		Mouse	PMID:12213961
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Stat4	IDA		Mouse	PMID:11894097
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	Stat4	IMP		Mouse	PMID:26880577
Biological Process	GO:0035722	interleukin-12-mediated signaling pathway	STAT4	IDA		Human	PMID:7638186
Biological Process	GO:0070661	leukocyte proliferation	Stat4	IDA		Mouse	PMID:12213961
Biological Process	GO:0010628	positive regulation of gene expression	Stat4	IGI	MGI:MGI:1888984	Mouse	PMID:22851706
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Stat4	IMP		Mouse	MGI:MGI:5543522|PMID:23772023
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Stat4	IDA		Mouse	PMID:19666510
Biological Process	GO:0006468	protein phosphorylation	Stat4	IDA		Mouse	PMID:11489994
Biological Process	GO:0045063	T-helper 1 cell differentiation	STAT4	IDA		Human	PMID:14688310
Biological Process	GO:0001570	vasculogenesis	stat4	IMP	ZFIN:ZDB-GENO-190412-26	Zfish	PMID:28256502

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern