Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes STAT5A
  • Mouse genes Stat5a
  • Rat genes Stat5a
  • Zfish genes stat5a,stat5b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Stat5a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Stat5a	IDA		Mouse	PMID:12388746
Molecular Function	GO:0003677	DNA binding	Stat5a	IDA		Mouse	PMID:10485657
Molecular Function	GO:0003677	DNA binding	Stat5a	IDA		Mouse	PMID:12147240
Molecular Function	GO:0003677	DNA binding	stat5a	IDA		Zfish	PMID:24835394
Molecular Function	GO:0003677	DNA binding	stat5a	IDA		Zfish	PMID:29246863
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Stat5a	IDA		Mouse	MGI:MGI:5825436|PMID:12393611
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Stat5a	IMP		Mouse	MGI:MGI:5825436|PMID:12393611
Molecular Function	GO:0003700	DNA-binding transcription factor activity	STAT5A	IDA		Human	PMID:10919676
Molecular Function	GO:0003700	DNA-binding transcription factor activity	STAT5A	IDA		Human	PMID:12393707
Molecular Function	GO:0003700	DNA-binding transcription factor activity	STAT5A	IDA		Human	PMID:7568001
Molecular Function	GO:0003700	DNA-binding transcription factor activity	STAT5A	IDA		Human	PMID:8580378
Molecular Function	GO:0003700	DNA-binding transcription factor activity	STAT5A	IDA		Human	PMID:8631883
Molecular Function	GO:0003700	DNA-binding transcription factor activity	STAT5A	IDA		Human	PMID:9516478
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Stat5a	IDA		Rat	PMID:11064147|RGD:1624963
Molecular Function	GO:0003700	DNA-binding transcription factor activity	stat5a	IDA		Zfish	PMID:29246863
Molecular Function	GO:0140297	DNA-binding transcription factor binding	STAT5A	IPI	UniProtKB:Q9BQW3	Human	PMID:35939714
Molecular Function	GO:0003690	double-stranded DNA binding	Stat5a	IDA		Rat	PMID:11064147|RGD:1624963
Molecular Function	GO:0003690	double-stranded DNA binding	Stat5a	IDA		Rat	PMID:8584036|RGD:730121
Molecular Function	GO:0042301	phosphate ion binding	Stat5a	IDA		Mouse	MGI:MGI:82362|PMID:8702683
Molecular Function	GO:0005515	protein binding	STAT5A	IPI	UniProtKB:P18031	Human	PMID:12237455
Molecular Function	GO:0005515	protein binding	STAT5A	IPI	UniProtKB:P41182	Human	PMID:16819511
Molecular Function	GO:0005515	protein binding	STAT5A	IPI	UniProtKB:Q99490-2	Human	PMID:20075866
Molecular Function	GO:0005515	protein binding	STAT5A	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	STAT5A	IPI	UniProtKB:Q99081	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	STAT5A	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	Stat5a	IPI	UniProtKB:P19941	Mouse	MGI:MGI:5508604|PMID:17666591
Molecular Function	GO:0005515	protein binding	Stat5a	IPI	UniProtKB:P16882|UniProtKB:P19756	Mouse	MGI:MGI:82362|PMID:8702683
Molecular Function	GO:0005515	protein binding	Stat5a	IPI	PR:Q08501	Mouse	PMID:20075866
Molecular Function	GO:0005515	protein binding	Stat5a	IPI	PR:Q3UHD9	Mouse	PMID:20075866
Molecular Function	GO:0005515	protein binding	Stat5a	IPI	PR:Q569L8	Mouse	PMID:12198240
Molecular Function	GO:0005515	protein binding	Stat5a	IPI	PR:Q08481	Mouse	PMID:11254359
Molecular Function	GO:0005515	protein binding	Stat5a	IPI	RGD:3982	Rat	PMID:10713133|RGD:9588247
Molecular Function	GO:0005515	protein binding	Stat5a	IPI	RGD:1308531	Rat	PMID:10720695|RGD:7488900
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Stat5a	IDA		Mouse	PMID:19666510
Molecular Function	GO:0043565	sequence-specific DNA binding	Stat5a	IDA		Mouse	MGI:MGI:5825436|PMID:12393611
Molecular Function	GO:0043565	sequence-specific DNA binding	Stat5a	IDA		Rat	PMID:11064147|RGD:1624963
Cellular Component	GO:0005737	cytoplasm	Stat5a	IDA		Mouse	PMID:14522949
Cellular Component	GO:0005737	cytoplasm	Stat5a	IDA		Mouse	PMID:11254359
Cellular Component	GO:0005737	cytoplasm	Stat5a	IDA		Rat	PMID:15609129|RGD:2291932
Cellular Component	GO:0005737	cytoplasm	Stat5a	IDA		Rat	PMID:8584036|RGD:730121
Cellular Component	GO:0005829	cytosol	STAT5A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	STAT5A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	STAT5A	IDA		Human	PMID:9516478
Cellular Component	GO:0005634	nucleus	Stat5a	IDA		Mouse	MGI:MGI:2446740|PMID:12456807
Cellular Component	GO:0005634	nucleus	Stat5a	IDA		Rat	PMID:7519723|RGD:151665740
Cellular Component	GO:0005634	nucleus	Stat5a	IDA		Rat	PMID:8584036|RGD:730121
Biological Process	GO:0050798	activated T cell proliferation	Stat5a	IDA		Mouse	PMID:10072077
Biological Process	GO:0050798	activated T cell proliferation	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10485657
Biological Process	GO:0050798	activated T cell proliferation	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10072077
Biological Process	GO:0030183	B cell differentiation	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10979977
Biological Process	GO:0008283	cell population proliferation	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10652277
Biological Process	GO:0008283	cell population proliferation	Stat5a	IDA		Mouse	PMID:10652277
Biological Process	GO:0071345	cellular response to cytokine stimulus	Stat5a	IDA		Rat	PMID:19414010|RGD:10402041
Biological Process	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	Stat5a	IDA		Mouse	PMID:23610142
Biological Process	GO:0071407	cellular response to organic cyclic compound	Stat5a	IDA		Rat	PMID:19414010|RGD:10402041
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Stat5a	IDA		Mouse	PMID:10485657
Biological Process	GO:0046543	development of secondary female sexual characteristics	Stat5a	IMP	MGI:MGI:2181607	Mouse	PMID:9630227
Biological Process	GO:0046544	development of secondary male sexual characteristics	Stat5a	IMP	MGI:MGI:2181607	Mouse	PMID:9630227
Biological Process	GO:0046544	development of secondary male sexual characteristics	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:9630227
Biological Process	GO:0048589	developmental growth	stat5a	IMP	ZFIN:ZDB-GENO-180718-13	Zfish	PMID:29246863
Biological Process	GO:0048589	developmental growth	stat5a	IMP	ZFIN:ZDB-GENO-180718-12	Zfish	PMID:29246863
Biological Process	GO:0030222	eosinophil differentiation	STAT5A	IDA		Human	PMID:12393707
Biological Process	GO:0060742	epithelial cell differentiation involved in prostate gland development	Stat5a	IMP	MGI:MGI:1857249	Mouse	PMID:10908145
Biological Process	GO:0048821	erythrocyte development	stat5a	IMP		Zfish	PMID:16459186
Biological Process	GO:0030218	erythrocyte differentiation	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10072077
Biological Process	GO:0030218	erythrocyte differentiation	stat5a	IMP	ZFIN:ZDB-MRPHLNO-080324-3,ZFIN:ZDB-MRPHLNO-080324-4	Zfish	PMID:17579187
Biological Process	GO:0030218	erythrocyte differentiation	stat5a	IGI	ZFIN:ZDB-GENE-980526-481	Zfish	PMID:19772888
Biological Process	GO:0007565	female pregnancy	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:15471942
Biological Process	GO:0042492	gamma-delta T cell differentiation	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:15294943
Biological Process	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	Stat5a	IDA		Mouse	MGI:MGI:82362|PMID:8702683
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	STAT5A	IDA		Human	PMID:7568001
Biological Process	GO:0032623	interleukin-2 production	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10072077
Biological Process	GO:0038110	interleukin-2-mediated signaling pathway	STAT5A	IDA		Human	PMID:8631883
Biological Process	GO:0038156	interleukin-3-mediated signaling pathway	STAT5A	IDA		Human	PMID:22102340
Biological Process	GO:0035771	interleukin-4-mediated signaling pathway	STAT5A	IDA		Human	PMID:17200144
Biological Process	GO:0038043	interleukin-5-mediated signaling pathway	STAT5A	IDA		Human	PMID:12393707
Biological Process	GO:0038113	interleukin-9-mediated signaling pathway	STAT5A	IDA		Human	PMID:10919676
Biological Process	GO:0007595	lactation	Stat5a	IMP	MGI:MGI:1857249	Mouse	PMID:11706048
Biological Process	GO:0007595	lactation	Stat5a	IMP	MGI:MGI:2181607	Mouse	PMID:9630227
Biological Process	GO:0007595	lactation	Stat5a	IEP		Rat	PMID:7519723|RGD:151665740
Biological Process	GO:0007595	lactation	Stat5a	IEP		Rat	PMID:8584036|RGD:730121
Biological Process	GO:0019915	lipid storage	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:9630227
Biological Process	GO:0001553	luteinization	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:9630227
Biological Process	GO:0030098	lymphocyte differentiation	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:15294943
Biological Process	GO:0030098	lymphocyte differentiation	stat5a	IMP		Zfish	PMID:16459186
Biological Process	GO:0030879	mammary gland development	Stat5a	IMP	MGI:MGI:2181607	Mouse	PMID:9630227
Biological Process	GO:0061180	mammary gland epithelium development	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:12040017
Biological Process	GO:0061180	mammary gland epithelium development	Stat5a	IMP	MGI:MGI:103036	Mouse	PMID:12040017
Biological Process	GO:0060056	mammary gland involution	Stat5a	IDA		Rat	PMID:16227201|RGD:2291942
Biological Process	GO:0033024	mast cell apoptotic process	Stat5a	IMP	MGI:MGI:1857249	Mouse	PMID:15947484
Biological Process	GO:0060374	mast cell differentiation	Stat5a	IMP	MGI:MGI:1857249	Mouse	PMID:15947484
Biological Process	GO:0070662	mast cell proliferation	Stat5a	IMP	MGI:MGI:1857249	Mouse	PMID:15947484
Biological Process	GO:0000278	mitotic cell cycle	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10072077
Biological Process	GO:0048609	multicellular organismal reproductive process	Stat5a	IEP		Rat	PMID:17433024|RGD:2291937
Biological Process	GO:0033028	myeloid cell apoptotic process	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10652277
Biological Process	GO:0001779	natural killer cell differentiation	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10072077
Biological Process	GO:0001779	natural killer cell differentiation	Stat5a	IMP	MGI:MGI:1857249	Mouse	PMID:9841920
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	Stat5a	IMP	MGI:MGI:1857249	Mouse	PMID:9841920
Biological Process	GO:0045647	negative regulation of erythrocyte differentiation	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10072077
Biological Process	GO:0033026	negative regulation of mast cell apoptotic process	Stat5a	IMP	MGI:MGI:1857249	Mouse	PMID:15947484
Biological Process	GO:0033033	negative regulation of myeloid cell apoptotic process	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10652277
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Stat5a	IDA		Mouse	PMID:12388746
Biological Process	GO:0048541	Peyer's patch development	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:15294943
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10072077
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10485657
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	Stat5a	IDA		Mouse	PMID:10072077
Biological Process	GO:0045579	positive regulation of B cell differentiation	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10979977
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	STAT5A	IMP		Human	PMID:20489169
Biological Process	GO:0008284	positive regulation of cell population proliferation	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10652277
Biological Process	GO:0008284	positive regulation of cell population proliferation	Stat5a	IDA		Mouse	PMID:10652277
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	STAT5A	IMP		Human	PMID:20489169
Biological Process	GO:0045588	positive regulation of gamma-delta T cell differentiation	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:15294943
Biological Process	GO:0050729	positive regulation of inflammatory response	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10652277
Biological Process	GO:0032743	positive regulation of interleukin-2 production	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10072077
Biological Process	GO:0045621	positive regulation of lymphocyte differentiation	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:15294943
Biological Process	GO:0060376	positive regulation of mast cell differentiation	Stat5a	IMP	MGI:MGI:1857249	Mouse	PMID:15947484
Biological Process	GO:0070668	positive regulation of mast cell proliferation	Stat5a	IMP	MGI:MGI:1857249	Mouse	PMID:15947484
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10072077
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:9630227
Biological Process	GO:0045639	positive regulation of myeloid cell differentiation	stat5a	IMP		Zfish	PMID:16459186
Biological Process	GO:0032825	positive regulation of natural killer cell differentiation	Stat5a	IMP	MGI:MGI:1857249	Mouse	PMID:9841920
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Stat5a	IMP	MGI:MGI:1857249	Mouse	PMID:9841920
Biological Process	GO:0042102	positive regulation of T cell proliferation	Stat5a	IMP	MGI:MGI:1857249	Mouse	PMID:15947484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Stat5a	IMP		Mouse	MGI:MGI:5825436|PMID:12393611
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10652277
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Stat5a	IMP	MGI:MGI:2181607	Mouse	PMID:9630227
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10485657
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Stat5a	IDA		Mouse	PMID:19666510
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	stat5a	IDA		Zfish	PMID:16459186
Biological Process	GO:0060740	prostate gland epithelium morphogenesis	Stat5a	IMP	MGI:MGI:1857249	Mouse	PMID:10908145
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Stat5a	IDA		Mouse	PMID:10485657
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Stat5a	IDA		Rat	PMID:11064147|RGD:1624963
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	stat5a	IGI	ZFIN:ZDB-MRPHLNO-100427-10,ZFIN:ZDB-MRPHLNO-120524-9	Zfish	PMID:21421851
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	stat5a	IMP		Zfish	PMID:19772888
Biological Process	GO:0038026	reelin-mediated signaling pathway	STAT5A	IDA		Human	PMID:29581031
Biological Process	GO:0030155	regulation of cell adhesion	Stat5a	IMP	MGI:MGI:1857249	Mouse	PMID:11706048
Biological Process	GO:0030856	regulation of epithelial cell differentiation	Stat5a	IMP	MGI:MGI:1857249	Mouse	PMID:11706048
Biological Process	GO:0040014	regulation of multicellular organism growth	Stat5a	IGI	UniProtKB:P16882,UniProtKB:P42232	Mouse	MGI:MGI:3804595|PMID:18648510
Biological Process	GO:0019218	regulation of steroid metabolic process	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:15471942
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Stat5a	IDA		Mouse	PMID:21217760
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:15294943
Biological Process	GO:0045471	response to ethanol	Stat5a	IEP		Rat	PMID:16946407|RGD:2291941
Biological Process	GO:0031667	response to nutrient levels	Stat5a	IEP		Rat	PMID:16946407|RGD:2291941
Biological Process	GO:0043434	response to peptide hormone	Stat5a	IDA		Mouse	PMID:12388746
Biological Process	GO:0033077	T cell differentiation in thymus	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:15294943
Biological Process	GO:0043029	T cell homeostasis	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10072077
Biological Process	GO:0042098	T cell proliferation	Stat5a	IMP	MGI:MGI:1857249	Mouse	PMID:15947484
Biological Process	GO:0019530	taurine metabolic process	Stat5a	IGI	UniProtKB:P16882,UniProtKB:P42232	Mouse	MGI:MGI:3804595|PMID:18648510
Biological Process	GO:0006366	transcription by RNA polymerase II	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10652277
Biological Process	GO:0006366	transcription by RNA polymerase II	Stat5a	IMP	MGI:MGI:2181607	Mouse	PMID:9630227
Biological Process	GO:0006366	transcription by RNA polymerase II	Stat5a	IGI	MGI:MGI:103035	Mouse	PMID:10485657
Biological Process	GO:0006366	transcription by RNA polymerase II	Stat5a	IDA		Rat	PMID:11064147|RGD:1624963

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern