Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes STAT5B
  • Mouse genes Stat5b
  • Rat genes Stat5b
  • Zfish genes stat5a,stat5b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Stat5b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Stat5b	IDA		Rat	PMID:20639532|RGD:8553583
Molecular Function	GO:0003677	DNA binding	Stat5b	IDA		Mouse	PMID:22801370
Molecular Function	GO:0003677	DNA binding	Stat5b	IDA		Mouse	PMID:12147240
Molecular Function	GO:0003677	DNA binding	Stat5b	IDA		Mouse	PMID:10485657
Molecular Function	GO:0003677	DNA binding	Stat5b	IDA		Rat	PMID:11562369|RGD:70587
Molecular Function	GO:0003677	DNA binding	stat5a	IDA		Zfish	PMID:24835394
Molecular Function	GO:0003677	DNA binding	stat5a	IDA		Zfish	PMID:29246863
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	STAT5B	IDA		Human	PMID:29844444
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Stat5b	IDA		Mouse	MGI:MGI:4355633|PMID:19666510
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Stat5b	IDA		Rat	PMID:11064147|RGD:1624963
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Stat5b	IDA		Rat	PMID:11562369|RGD:70587
Molecular Function	GO:0003700	DNA-binding transcription factor activity	stat5a	IDA		Zfish	PMID:29246863
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Stat5b	IPI	RGD:3772	Rat	PMID:16527988|RGD:1601384
Molecular Function	GO:0003690	double-stranded DNA binding	Stat5b	IDA		Rat	PMID:11064147|RGD:1624963
Molecular Function	GO:0042802	identical protein binding	STAT5B	IPI	UniProtKB:P51692	Human	PMID:31175292
Molecular Function	GO:0035259	nuclear glucocorticoid receptor binding	STAT5B	IPI	UniProtKB:P04150	Human	PMID:12552091
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:Q02083	Human	PMID:21106534
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:Q96EY1	Human	PMID:21106534
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:Q96EY1-1	Human	PMID:21106534
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:P00519	Human	PMID:31175292
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:I6L957	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:O75604	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:P38936	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:P51687	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:P61968	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:P82932	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:Q09028	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:Q13111	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:Q71SY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:Q86VK4-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:Q8TCE9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:Q92569	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:Q96PN8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:Q99469	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STAT5B	IPI	UniProtKB:Q13287	Human	PMID:9989503
Molecular Function	GO:0005515	protein binding	Stat5b	IPI	UniProtKB:Q96EY1-1|UniProtKB:Q96EY1-2|UniProtKB:Q96EY1	Mouse	MGI:MGI:5285141|PMID:21106534
Molecular Function	GO:0005515	protein binding	Stat5b	IPI	UniProtKB:Q8NE35	Mouse	MGI:MGI:5050399|PMID:20639532
Molecular Function	GO:0005515	protein binding	Stat5b	IPI	UniProtKB:P19941	Mouse	MGI:MGI:5508604|PMID:17666591
Molecular Function	GO:0005515	protein binding	Stat5b	IPI	PR:A6H687	Mouse	PMID:18838617
Molecular Function	GO:0005515	protein binding	Stat5b	IPI	RGD:1308531	Rat	PMID:10720695|RGD:7488900
Molecular Function	GO:0046983	protein dimerization activity	Stat5b	IDA		Mouse	MGI:MGI:5050399|PMID:20639532
Molecular Function	GO:0042803	protein homodimerization activity	STAT5B	IDA		Human	PMID:29844444
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Stat5b	IDA		Mouse	PMID:19666510
Molecular Function	GO:0043565	sequence-specific DNA binding	Stat5b	IDA		Rat	PMID:11064147|RGD:1624963
Cellular Component	GO:0005737	cytoplasm	STAT5B	IDA		Human	PMID:29844444
Cellular Component	GO:0005737	cytoplasm	Stat5b	IDA		Mouse	MGI:MGI:5050399|PMID:20639532
Cellular Component	GO:0005737	cytoplasm	Stat5b	IDA		Mouse	PMID:12634107
Cellular Component	GO:0005829	cytosol	Stat5b	IDA		Rat	PMID:12933671|RGD:1601385
Cellular Component	GO:0005634	nucleus	STAT5B	IDA		Human	PMID:29844444
Cellular Component	GO:0005634	nucleus	Stat5b	IDA		Mouse	MGI:MGI:5050399|PMID:20639532
Cellular Component	GO:0005634	nucleus	Stat5b	IDA		Mouse	PMID:12147240
Cellular Component	GO:0005634	nucleus	Stat5b	IDA		Rat	PMID:17327369|RGD:1601383
Biological Process	GO:0050798	activated T cell proliferation	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10485657
Biological Process	GO:0050798	activated T cell proliferation	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10072077
Biological Process	GO:0050798	activated T cell proliferation	Stat5b	IMP	MGI:MGI:2181592	Mouse	PMID:9841920
Biological Process	GO:0006953	acute-phase response	Stat5b	IDA		Rat	PMID:17565389|RGD:2291935
Biological Process	GO:0030183	B cell differentiation	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10979977
Biological Process	GO:0008283	cell population proliferation	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10652277
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	Stat5b	IDA		Rat	PMID:20639532|RGD:8553583
Biological Process	GO:0071363	cellular response to growth factor stimulus	Stat5b	IDA		Mouse	MGI:MGI:5050399|PMID:20639532
Biological Process	GO:0032870	cellular response to hormone stimulus	STAT5B	IDA		Human	PMID:12552091
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Stat5b	IDA		Mouse	PMID:10485657
Biological Process	GO:0046543	development of secondary female sexual characteristics	Stat5b	IMP	MGI:MGI:2181609	Mouse	PMID:9630227
Biological Process	GO:0046544	development of secondary male sexual characteristics	Stat5b	IMP	MGI:MGI:2181609	Mouse	PMID:9630227
Biological Process	GO:0046544	development of secondary male sexual characteristics	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:9630227
Biological Process	GO:0048589	developmental growth	stat5a	IMP	ZFIN:ZDB-GENO-180718-13	Zfish	PMID:29246863
Biological Process	GO:0048589	developmental growth	stat5a	IMP	ZFIN:ZDB-GENO-180718-12	Zfish	PMID:29246863
Biological Process	GO:0048821	erythrocyte development	stat5a	IMP		Zfish	PMID:16459186
Biological Process	GO:0030218	erythrocyte differentiation	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10072077
Biological Process	GO:0030218	erythrocyte differentiation	stat5a	IMP	ZFIN:ZDB-MRPHLNO-080324-3,ZFIN:ZDB-MRPHLNO-080324-4	Zfish	PMID:17579187
Biological Process	GO:0030218	erythrocyte differentiation	stat5a	IGI	ZFIN:ZDB-GENE-980526-481	Zfish	PMID:19772888
Biological Process	GO:0007565	female pregnancy	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:15471942
Biological Process	GO:0007565	female pregnancy	Stat5b	IMP	MGI:MGI:2181609	Mouse	PMID:15471942
Biological Process	GO:0042492	gamma-delta T cell differentiation	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:15294943
Biological Process	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	STAT5B	IDA		Human	PMID:12552091
Biological Process	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	Stat5b	IDA		Mouse	MGI:MGI:3828422|PMID:8923468
Biological Process	GO:0032623	interleukin-2 production	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10072077
Biological Process	GO:0007595	lactation	Stat5b	IMP	MGI:MGI:2181609	Mouse	PMID:11706048
Biological Process	GO:0007595	lactation	Stat5b	IMP	MGI:MGI:2181609	Mouse	PMID:9630227
Biological Process	GO:0019915	lipid storage	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:9630227
Biological Process	GO:0001889	liver development	Stat5b	IDA		Rat	PMID:17565389|RGD:2291935
Biological Process	GO:0001553	luteinization	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:9630227
Biological Process	GO:0001553	luteinization	Stat5b	IDA		Rat	PMID:10598581|RGD:1601386
Biological Process	GO:0030098	lymphocyte differentiation	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:15294943
Biological Process	GO:0030098	lymphocyte differentiation	stat5a	IMP		Zfish	PMID:16459186
Biological Process	GO:0097531	mast cell migration	Stat5b	IMP		Mouse	PMID:24068671
Biological Process	GO:0000278	mitotic cell cycle	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10072077
Biological Process	GO:0033028	myeloid cell apoptotic process	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10652277
Biological Process	GO:0001779	natural killer cell differentiation	Stat5b	IMP	MGI:MGI:2181592	Mouse	PMID:9841920
Biological Process	GO:0001779	natural killer cell differentiation	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10072077
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	Stat5b	IMP	MGI:MGI:2181592	Mouse	PMID:9841920
Biological Process	GO:0001787	natural killer cell proliferation	Stat5b	IMP	MGI:MGI:2181592	Mouse	PMID:9841920
Biological Process	GO:0045647	negative regulation of erythrocyte differentiation	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10072077
Biological Process	GO:0033033	negative regulation of myeloid cell apoptotic process	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10652277
Biological Process	GO:0048541	Peyer's patch development	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:15294943
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	Stat5b	IMP	MGI:MGI:2181592	Mouse	PMID:9841920
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10072077
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10485657
Biological Process	GO:0045579	positive regulation of B cell differentiation	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10979977
Biological Process	GO:0008284	positive regulation of cell population proliferation	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10652277
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	STAT5B	IDA		Human	PMID:20702587
Biological Process	GO:0090271	positive regulation of fibroblast growth factor production	Stat5b	IMP		Rat	PMID:16527988|RGD:1601384
Biological Process	GO:0045588	positive regulation of gamma-delta T cell differentiation	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:15294943
Biological Process	GO:0010628	positive regulation of gene expression	Stat5b	IMP		Rat	PMID:16527988|RGD:1601384
Biological Process	GO:0050729	positive regulation of inflammatory response	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10652277
Biological Process	GO:0032743	positive regulation of interleukin-2 production	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10072077
Biological Process	GO:0045621	positive regulation of lymphocyte differentiation	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:15294943
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10072077
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:9630227
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Stat5b	IMP	MGI:MGI:2181609	Mouse	PMID:9630227
Biological Process	GO:0045639	positive regulation of myeloid cell differentiation	stat5a	IMP		Zfish	PMID:16459186
Biological Process	GO:0032825	positive regulation of natural killer cell differentiation	Stat5b	IMP	MGI:MGI:2181592	Mouse	PMID:9841920
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Stat5b	IMP	MGI:MGI:2181592	Mouse	PMID:9841920
Biological Process	GO:0032819	positive regulation of natural killer cell proliferation	Stat5b	IMP	MGI:MGI:2181592	Mouse	PMID:9841920
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Stat5b	IMP		Rat	PMID:16527988|RGD:1601384
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Stat5b	IMP		Rat	PMID:16527988|RGD:1601384
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Stat5b	IDA		Mouse	MGI:MGI:5050399|PMID:20639532
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Stat5b	IDA		Mouse	MGI:MGI:5285141|PMID:21106534
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Stat5b	IDA		Mouse	PMID:19666510
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Stat5b	IMP	MGI:MGI:2181609	Mouse	PMID:9630227
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10652277
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10485657
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	stat5a	IDA		Zfish	PMID:16459186
Biological Process	GO:0042448	progesterone metabolic process	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:15471942
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Stat5b	IDA		Mouse	PMID:10485657
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Stat5b	IDA		Rat	PMID:11064147|RGD:1624963
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	stat5a	IGI	ZFIN:ZDB-MRPHLNO-100427-10,ZFIN:ZDB-MRPHLNO-120524-9	Zfish	PMID:21421851
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	stat5a	IMP		Zfish	PMID:19772888
Biological Process	GO:0030155	regulation of cell adhesion	Stat5b	IMP	MGI:MGI:2181609	Mouse	PMID:11706048
Biological Process	GO:0006355	regulation of DNA-templated transcription	Stat5b	IDA		Rat	PMID:11562369|RGD:70587
Biological Process	GO:0030856	regulation of epithelial cell differentiation	Stat5b	IMP	MGI:MGI:2181609	Mouse	PMID:11706048
Biological Process	GO:0040014	regulation of multicellular organism growth	Stat5b	IGI	UniProtKB:P16882,UniProtKB:P42230	Mouse	MGI:MGI:3804595|PMID:18648510
Biological Process	GO:0019218	regulation of steroid metabolic process	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:15471942
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:15294943
Biological Process	GO:0032355	response to estradiol	STAT5B	IDA		Human	PMID:12552091
Biological Process	GO:0045471	response to ethanol	Stat5b	IEP		Rat	PMID:12933671|RGD:1601385
Biological Process	GO:0001666	response to hypoxia	Stat5b	IEP		Rat	PMID:16730240|RGD:1601380
Biological Process	GO:0070672	response to interleukin-15	Stat5b	IMP	MGI:MGI:2181592	Mouse	PMID:9841920
Biological Process	GO:0070669	response to interleukin-2	Stat5b	IMP	MGI:MGI:2181592	Mouse	PMID:9841920
Biological Process	GO:0070670	response to interleukin-4	Stat5b	IMP	MGI:MGI:2181592	Mouse	PMID:9841920
Biological Process	GO:0032496	response to lipopolysaccharide	Stat5b	IDA		Rat	PMID:17327369|RGD:1601383
Biological Process	GO:0043434	response to peptide hormone	Stat5b	IEP		Rat	PMID:10224108|RGD:1601382
Biological Process	GO:0043434	response to peptide hormone	Stat5b	IDA		Rat	PMID:9092792|RGD:1601387
Biological Process	GO:0007548	sex differentiation	Stat5b	IMP	MGI:MGI:2181592	Mouse	PMID:17412818
Biological Process	GO:0033077	T cell differentiation in thymus	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:15294943
Biological Process	GO:0043029	T cell homeostasis	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10072077
Biological Process	GO:0019530	taurine metabolic process	Stat5b	IGI	UniProtKB:P16882,UniProtKB:P42230	Mouse	MGI:MGI:3804595|PMID:18648510
Biological Process	GO:0006366	transcription by RNA polymerase II	Stat5b	IMP	MGI:MGI:2181609	Mouse	PMID:9630227
Biological Process	GO:0006366	transcription by RNA polymerase II	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10485657
Biological Process	GO:0006366	transcription by RNA polymerase II	Stat5b	IGI	MGI:MGI:103036	Mouse	PMID:10652277
Biological Process	GO:0006366	transcription by RNA polymerase II	Stat5b	IDA		Rat	PMID:11064147|RGD:1624963

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern