Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes STAT6
  • Mouse genes Stat6
  • Rat genes Stat6
  • Zfish genes stat6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Stat6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	STAT6	IDA		Human	PMID:8810328
Molecular Function	GO:0003700	DNA-binding transcription factor activity	STAT6	IDA		Human	PMID:8816495
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Stat6	IMP		Rat	PMID:15584925|RGD:2298576
Molecular Function	GO:0042802	identical protein binding	STAT6	IPI	UniProtKB:P42226	Human	PMID:22000020
Molecular Function	GO:0005515	protein binding	STAT6	IPI	UniProtKB:Q13287	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	STAT6	IPI	UniProtKB:Q86WV6	Human	PMID:22000020
Molecular Function	GO:0005515	protein binding	STAT6	IPI	UniProtKB:Q9UHD2	Human	PMID:22000020
Molecular Function	GO:0005515	protein binding	STAT6	IPI	UniProtKB:Q09472	Human	PMID:23461825
Molecular Function	GO:0005515	protein binding	STAT6	IPI	UniProtKB:P24394	Human	PMID:8816495
Molecular Function	GO:0005515	protein binding	STAT6	IPI	UniProtKB:P24394	Human	PMID:9392697
Molecular Function	GO:0005515	protein binding	STAT6	IPI	UniProtKB:P24394	Human	PMID:9651359
Molecular Function	GO:0005515	protein binding	STAT6	IPI	UniProtKB:Q13287	Human	PMID:9989503
Molecular Function	GO:0005515	protein binding	Stat6	IPI	UniProtKB:Q2EMV9	Mouse	MGI:MGI:3621509|PMID:16537510
Molecular Function	GO:0019903	protein phosphatase binding	STAT6	IPI	UniProtKB:P17706-2	Human	PMID:17210636
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Stat6	IDA		Mouse	PMID:22588720
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Stat6	IDA		Mouse	PMID:10490661
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	STAT6	IDA		Human	PMID:8810328
Molecular Function	GO:0043565	sequence-specific DNA binding	Stat6	IDA		Mouse	PMID:15659391
Molecular Function	GO:0043565	sequence-specific DNA binding	Stat6	IMP		Rat	PMID:15584925|RGD:2298576
Molecular Function	GO:0043565	sequence-specific DNA binding	Stat6	IDA		Rat	PMID:16648019|RGD:2298581
Molecular Function	GO:0001223	transcription coactivator binding	STAT6	EXP		Human	PMID:29203888
Cellular Component	GO:0000785	chromatin	Stat6	IDA		Mouse	MGI:MGI:3044839|PMID:15187136
Cellular Component	GO:0005737	cytoplasm	Stat6	IDA		Mouse	PMID:12634107
Cellular Component	GO:0005737	cytoplasm	Stat6	IDA		Mouse	PMID:12093868
Cellular Component	GO:0005829	cytosol	STAT6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045121	membrane raft	Stat6	IDA		Rat	PMID:22504638|RGD:7244148
Cellular Component	GO:0005654	nucleoplasm	STAT6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	STAT6	IDA		Human	PMID:7694370
Cellular Component	GO:0005634	nucleus	Stat6	IDA		Mouse	PMID:12093868
Cellular Component	GO:0005634	nucleus	Stat6	IDA		Rat	PMID:16648019|RGD:2298581
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	STAT6	IPI		Human	PMID:22000020
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Stat6	IDA		Rat	PMID:22504638|RGD:7244148
Biological Process	GO:1902170	cellular response to reactive nitrogen species	Stat6	IDA		Rat	PMID:22504638|RGD:7244148
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Stat6	IMP		Rat	PMID:18362439|RGD:2298568
Biological Process	GO:0010467	gene expression	Stat6	IMP		Mouse	PMID:31408278
Biological Process	GO:0045087	innate immune response	stat6	IMP	ZFIN:ZDB-MRPHLNO-181024-1	Zfish	PMID:29942316
Biological Process	GO:0035771	interleukin-4-mediated signaling pathway	STAT6	IMP		Human	PMID:17210636
Biological Process	GO:0035771	interleukin-4-mediated signaling pathway	STAT6	IDA		Human	PMID:7760829
Biological Process	GO:0035771	interleukin-4-mediated signaling pathway	Stat6	IMP		Mouse	MGI:MGI:5493214|PMID:17210636
Biological Process	GO:0048289	isotype switching to IgE isotypes	Stat6	IGI	MGI:MGI:107187	Mouse	PMID:10490661
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	Stat6	IMP	MGI:MGI:1888385	Mouse	PMID:22588720
Biological Process	GO:0060443	mammary gland morphogenesis	Stat6	IMP	MGI:MGI:1888385	Mouse	PMID:22588720
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Stat6	IMP	MGI:MGI:1888385	Mouse	PMID:18997793
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Stat6	IDA		Mouse	PMID:20956546
Biological Process	GO:0002829	negative regulation of type 2 immune response	Stat6	IGI	MGI:MGI:107187	Mouse	PMID:10438949
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Stat6	IMP		Mouse	MGI:MGI:5603000|PMID:24906148
Biological Process	GO:0048295	positive regulation of isotype switching to IgE isotypes	Stat6	IGI	MGI:MGI:107187	Mouse	PMID:10490661
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	STAT6	IDA		Human	PMID:8810328
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Stat6	IMP	MGI:MGI:1888385	Mouse	PMID:21217760
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Stat6	IGI	MGI:MGI:96556	Mouse	PMID:9110977
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Stat6	IMP		Rat	PMID:15584925|RGD:2298576
Biological Process	GO:0070666	regulation of mast cell proliferation	Stat6	IDA		Mouse	PMID:12093868
Biological Process	GO:0034097	response to cytokine	Stat6	IMP		Rat	PMID:18362439|RGD:2298568
Biological Process	GO:0007165	signal transduction	Stat6	IMP	MGI:MGI:1888385	Mouse	PMID:17658279
Biological Process	GO:0002296	T-helper 1 cell lineage commitment	Stat6	IGI	MGI:MGI:96556	Mouse	PMID:20706986

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern